公开(公告)号：WO2023059224A1

公开(公告)日：2023-04-13

申请号：PCT/RU2022/050228

申请日：2022-07-21

申请人： JOINT STOCK COMPANY "PHARMASYNTEZ"

发明人： KURKIN, Alexander Vital'evich ,  KAZYULKIN, Denis Nikolaevich ,  MANASOVA, Ekaterina Vladimirovna ,  LUKIANENKO, Evgenii Renol'dovich ,  BELOV, Grigorii Mihajlovich ,  IUSUPOV, Ildar Rustemovich ,  SHURYGIN, Mikhail Gennad'evich

IPC分类号： C07D209/10 ,  C07D235/02 ,  C07D307/58 ,  C07F9/12 ,  C07F9/24 ,  C07C255/36 ,  A61K31/341 ,  A61K31/404 ,  A61K31/661 ,  A61K31/664 ,  A61P31/12

摘要： The invention relates to new biologically active derivatives of substituted 2,3-dihydrofuran-3-ones, which can be used as antiviral agents with a broad spectrum of antiviral activity. The compound represented by Formula (I) is described: Formula (I). Also a method for treating viral disease, a method for preventing viral disease, pharmaceutical composition comprising compound according to claims 1-5 and pharmaceutically acceptable carrier and a method for obtaining of the compound of Formula (I) are described. The technical result of this invention is the development and production of new chemical compounds with high efficacy for the treatment of diseases caused by RNA viruses.

公开(公告)号：WO2022251805A1

公开(公告)日：2022-12-01

申请号：PCT/US2022/072496

申请日：2022-05-23

申请人： MEDICON PHARMACEUTICALS, INC.

发明人： RIGAS, Basil

IPC分类号： A61K31/661 ,  A61P25/02

摘要： The invention features methods of preventing and/or treating neuropathic pain associated with chemotherapy-induced peripheral neuropathy (CIPN).

公开(公告)号：WO2022251177A2

公开(公告)日：2022-12-01

申请号：PCT/US2022/030674

申请日：2022-05-24

申请人： BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE SA

发明人： BOUREZG, Zouaoui ,  POUSSET, Cyrille

IPC分类号： A61K31/661 ,  A61K9/08 ,  A61P3/02 ,  A61P3/12 ,  C07F9/11 ,  A61K9/0029 ,  A61L2/0023 ,  C07F9/091

摘要： The present disclosure relates to a pharmaceutical composition for providing phosphorus to an adult or pediatric patient, wherein the composition is an aqueous solution of sodium glycerophosphate which by virtue of an improved process for producing the active pharmaceutical ingredient and the pharmaceutical composition is characterized by a low amount of free phosphate, a low amount of SGP-related substances and by a low amount of aluminum. The pharmaceutical composition is used in clinical nutrition, preferably in the preparation of nutritional formulations by compounding. The compositions can further be used for preventing or correcting phosphorus deficiency (hyperphosphatemia) in said adult or pediatric patients.

公开(公告)号：WO2022212399A1

公开(公告)日：2022-10-06

申请号：PCT/US2022/022376

申请日：2022-03-29

申请人： SPALLITTA, Frank Anthony

发明人： SPALLITTA, Frank Anthony

IPC分类号： A01N57/12 ,  A01N57/20 ,  A61K31/661

摘要： Provided herein are methods of treating a clinical symptom and/or transmission risk associated with a pathogen in an individual, including related pharmaceutical formulations, the method comprising the steps of: administering to the individual having the clinical symptom or at transmission risk of the pathogen, an active agent in a dosage effective to inactivate Demodex mites in or on the individual; thereby resulting in amelioration or cessation of the clinical symptoms and/or transmission risk associated with the pathogen.

公开(公告)号：WO2022183281A1

公开(公告)日：2022-09-09

申请号：PCT/CA2022/050283

申请日：2022-02-28

申请人： MCMASTER, Christopher R. ,  TAVASOLI, Mahtab

发明人： MCMASTER, Christopher R. ,  TAVASOLI, Mahtab

IPC分类号： A61K31/14 ,  A61K31/192 ,  A61K31/194 ,  A61K31/195 ,  A61K31/216 ,  A61K31/426 ,  A61K31/661 ,  A61K31/7068 ,  A61P21/00 ,  C07C59/72 ,  C07C59/255 ,  C07C69/708 ,  C07C215/08 ,  C07C233/73 ,  C07D277/26 ,  C07F9/09 ,  C07H19/10

摘要： Among other things, in general, compositions and methods of treatment for muscular dystrophy and other diseases are disclosed. A method of treatment of a subject is disclosed, in which fatty acid utilization is improved. The method includes administering to the subject in need thereof therapeutically effective amounts of a peroxisome proliferator-activated receptor (Ppar) agonist and of choline, or pharmaceutically acceptable salts or prodrugs thereof. Compositions including a Ppar agonist and choline are also provided.

公开(公告)号：WO2022104011A1

公开(公告)日：2022-05-19

申请号：PCT/US2021/059073

申请日：2021-11-12

申请人： YUMANITY THERAPEUTICS, INC.

发明人： VINCENT, Benjamin ,  TARDIFF, Daniel ,  PIOTROWSKI, Jeffrey ,  CHANG, Belle ,  CHOI, Jeonghoon ,  CHUNG, Chee-Yeun ,  SCANNEVIN, Robert

IPC分类号： A61K31/661 ,  A61K31/685 ,  A61K38/00 ,  A61K45/00 ,  A61P9/10 ,  A61P25/00

摘要： The present invention provides methods for treating alpha-synuclein-induced toxicity using phosphatidic acid to phosphoinositide biosynthesis pathway inhibitors, such as a nucleic acid molecule, a small molecule, or a nuclease, among others.

公开(公告)号：WO2022031898A1

公开(公告)日：2022-02-10

申请号：PCT/US2021/044619

申请日：2021-08-05

申请人： TLC BIQPHARMACEUTICALS. INC. ,  TAIWAN LIPOSOME COMPANY, LTD.

发明人： SHIH, Sheue-Fang ,  BROWN, Carl, Oscar

IPC分类号： A61K9/00 ,  A61K9/127 ,  A61K31/573 ,  A61P19/02 ,  A61K31/661 ,  A61K9/0019

摘要： Provided is a method for treating joint pain in a subject with arthritis. The method comprises administering to the subject with a determined grade of osteoarthritis an effective amount of intra- articular corticosteroid or pharmaceutically acceptable salt thereof in a pharmaceutical composition. Achieved is robustness of the efficacy response to a treatment with intra- articular corticosteroid in predetermined subgroups of the intent-to-treat population.

公开(公告)号：WO2022029015A2

公开(公告)日：2022-02-10

申请号：PCT/EP2021/071330

申请日：2021-07-29

申请人： UNIVERSITEIT GENT

发明人： CRABBÉ, Aurélie ,  COENYE, Tom ,  RIGAUTS, Charlotte

IPC分类号： A61K35/74 ,  A61P1/00 ,  A61P1/04 ,  A61P11/00 ,  A61P11/02 ,  A61P11/06 ,  A61P11/12 ,  A61P17/00 ,  A61P17/06 ,  A61P17/08 ,  A61P17/10 ,  A61K31/047 ,  A61K31/661 ,  A61K31/7008 ,  A61K31/7016 ,  A61K31/7034

摘要： The present invention relates to bacterial compositions, prebiotics and methods of use thereof. The bacterial compositions may include bacteria of the genera Rothia, Gemella or Roseomonas, and combinations thereof. The bacterial compositions and prebiotics may be used in treating inflammation, such as inflammation of the respiratory tract and skin inflammation.

公开(公告)号：WO2021257804A1

公开(公告)日：2021-12-23

申请号：PCT/US2021/037788

申请日：2021-06-17

申请人： AUTOBAHN THERAPEUTICS, INC.

发明人： VON GELDERN, Thomas ,  BACKES, Bradley

IPC分类号： A61K31/192 ,  A61K31/661 ,  A61K31/662

摘要： Disclosed herein are thyromimetic compounds having utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their preparation.

公开(公告)号：WO2021252636A1

公开(公告)日：2021-12-16

申请号：PCT/US2021/036628

申请日：2021-06-09

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： TKATCHENKO, Andrei V. ,  TKATCHENKO, Tatiana V.

IPC分类号： A61K9/00 ,  A61K31/661 ,  A61P27/10

摘要： The disclosure relates to methods and compositions for preventing and/or treating an ocular disease. In particular, the disclosure relates to preventing and/or treating myopia with systemic or topical administration of fingolimod phosphate, which is a sphingosine-1- phosphate receptor modulator, or a derivative thereof.