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公开(公告)号：WO2021026227A1
公开(公告)日：2021-02-11
申请号：PCT/US2020/044998
申请日：2020-08-05
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , RIELLA, Leonardo V. , COLLINS, James J. , KAMINSKI, Michael M.
IPC分类号： C12N9/22 , C12Q1/6888 , C12Q1/70
摘要： Described herein are nucleic acid detection systems, devices, and kits having a CRISPR component comprising an effector protein and a guide RNA, and/or a polynucleotide encoding a guide RNA, that binds or hybridizes to a corresponding target molecule. Also described herein are methods that utilize these nucleic acid systems, devices, and kits.
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公开(公告)号：WO2021021276A1
公开(公告)日：2021-02-04
申请号：PCT/US2020/034529
申请日：2020-05-26
发明人： GRODZINSKY, Alan , KRISHNAN, Yamini
摘要： Provided here in are methods and compositions for delivering a payload molecule to a charged avascular tissue or charged partially vascularized tissue in a subject, the method including administering to a subject in need thereof an effective amount of a carrier, wherein the carrier is a cationic carrier and/or has a surface charge distribution such that about 40% or greater of a continuous region of the surface is positively charged, and wherein the carrier is linked with a payload molecule, to deliver the payload molecule to the charged avascular tissue and/or the charged partially vascularized tissue.
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公开(公告)号：WO2021015839A1
公开(公告)日：2021-01-28
申请号：PCT/US2020/033587
申请日：2020-05-19
摘要： Disclosed are dielectric cavity arrays with cavities formed by pairs of dielectric tips, wherein the cavities have low mode volume (e.g., 7*10 -5 λ 3 , where λ is the resonance wavelength of the cavity array), and large quality factor Q (e.g., 10 6 or more). Applications for such dielectric cavity arrays include, but are not limited to, Raman spectroscopy, second harmonic generation, optical signal detection, microwave-to-optical transduction, and as light emitting devices.
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公开(公告)号：WO2020264361A1
公开(公告)日：2020-12-30
申请号：PCT/US2020/039910
申请日：2020-06-26
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , WISCONSIN ALUMNI RESEARCH FOUNDATION , RAINES, Ronald , WINDSOR, Ian
发明人： RAINES, Ronald , WINDSOR, Ian
IPC分类号： C12N9/22
摘要： Disclosed herein are circular zymogens of RNase 1 that have a proteolytic cleavage site and are activated by a specific protease. These circular zymogens are useful for treatment of disorders that are characterized by a specific protease (e.g., HIV-1 protease).
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公开(公告)号：WO2020252250A2
公开(公告)日：2020-12-17
申请号：PCT/US2020/037418
申请日：2020-06-12
IPC分类号： H02J1/10
摘要： A dc-dc converter can include a plurality of switches, a piezoelectric resonator (PR) for power stage energy storage, and a means for controlling one or more switching sequences. The switches operate in accordance with the switching sequences to transfer energy from the input to the output via the PR while providing low-loss resonant soft-charging of the PR's capacitance. The switching sequences include: connected stages in which a first and second PR terminals are both connected to one of the input, the output, or the other PR terminal; and open stages in which at least one of the first or second PR terminal is not connected by a closed switch to one of the input, the output, or the other PR terminal.
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公开(公告)号：WO2020247836A1
公开(公告)日：2020-12-10
申请号：PCT/US2020/036446
申请日：2020-06-05
IPC分类号： A61K31/00 , A61K35/38 , A61K48/00 , A61P1/00 , C12N1/38 , G01N33/50 , G01N33/53 , C12N5/071 , C12N15/63
摘要： The subject matter disclosed herein is generally directed to modulation of genes and pathways that drive differentiation of LGR5+ stem cells. The methods and compositions can be used to treat diseases associated with aberrant epithelial barrier function.
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公开(公告)号：WO2020247739A1
公开(公告)日：2020-12-10
申请号：PCT/US2020/036308
申请日：2020-06-05
IPC分类号： A61K9/00 , A61K35/644 , A61K47/46 , A61M37/00
摘要： A device, comprising a base, and a plurality of microneedles attached to the base, wherein the microneedles comprise dehydrated honey having water content of less than 5% by weight. The dehydrated honey can be a Manuka dehydrated honey. Also disclosed are methods of fabricating and using the disclosed device.
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公开(公告)号：WO2020247434A1
公开(公告)日：2020-12-10
申请号：PCT/US2020/035831
申请日：2020-06-03
IPC分类号： B08B17/06
摘要： Method and article for redirecting droplets impinging on the article, the article (14, 18, 22) comprising a non-wetting surface (210) having a dynamic contact angle (9d) of at least 90 degrees, the non- wetting surface (210) comprising a plurality of macro-scale features (220) configured to induce momentum redirection of a droplet (20) impinging onto the non-wetting surface (210), thereby reducing an area of contact between the droplet (20) and the non-wetting surface (210).
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公开(公告)号：WO2020247056A1
公开(公告)日：2020-12-10
申请号：PCT/US2020/026911
申请日：2020-04-06
发明人： RICHARDSON, Jonathan , AMIN, Mitesh
摘要： Devices and methods are provided herein for diagnosing, ranking, and/or tracking of stress fractures in biological materials such as bone and/or other hard tissue(s) using ultrasound imaging. The methods and devices provided herein include, for example: methods and devices for identifying a location on a bone; methods and devices for automated alignment of the transducer over a location of interest; and methods and devices for enhancing the sensitivity to in ultrasound imaging. The methods and devices provided herein may further provide for improved diagnosis, ranking, and/or tracking of stress fractures in bone and/or other hard tissue(s) by using signature characteristics of stress fractures.
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100.发明申请
公开(公告)号：WO2020247054A1
公开(公告)日：2020-12-10
申请号：PCT/US2020/026415
申请日：2020-04-02
发明人： MOVASSAGHI, Mohammad , OLSSON, Chase Robert , SCOTT, Tony, Z. , CHEAH, Jaime , PAYETTE, Joshua, Nathaniel
IPC分类号： C07D513/22 , A61P35/00 , A61K47/50
摘要： The present disclosure provides, e.g. , compounds, compositions, kits, methods of synthesis, and methods of use, involving epipolythiodiketopiperazines and polythiodiketopiperazines.
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