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公开(公告)号：WO2022106497A1
公开(公告)日：2022-05-27
申请号：PCT/EP2021/082045
申请日：2021-11-17
申请人： CARDIOMECH AS
发明人： HIORTH, Nikolai , HIORTH, Hans Emil
摘要： A catheter device for repair of the heart by implanting an artificial chordae line, a method of use of a catheter device for repair of the heart by implanting an artificial chordae line, and a method of manufacture of a catheter device for repair of the heart by implanting an artificial chordae line are described. A catheter device (102) for repair of the heart by implanting an artificial chordae line (114), the catheter device (102) comprising: a housing section extending from a distal end of the catheter device along the length of the catheter device toward a proximal end of the catheter device; a leaflet anchor (110) for placement in a leaflet (12) of a heart valve, wherein the leaflet anchor (110) is arranged to be coupled to the artificial chordae line (114); and a leaflet anchor deployment mechanism for deploying the leaflet anchor (110) to attach it to the leaflet (12) of the heart, wherein the leaflet anchor deployment mechanism comprises a mechanical gripper device (106) for grasping the leaflet (12) of the heart valve, and a leaflet anchor tube (138) for housing the leaflet anchor (110) in a folded configuration; the gripper device (106) and leaflet anchor (110) being arranged such that when, in use, the gripper device (106) grasps the leaflet (12), the leaflet anchor (110) can be pushed out of a leaflet anchor tube (138) to pierce the leaflet (12) and form the leaflet anchor (110) into an unfolded configuration so that hooked formations of the leaflet anchor (110) can, in use, secure the leaflet anchor (110) in the leaflet (12); wherein the mechanical gripper device (106) includes a gripper arm (130) rotatably coupled to a main body of the catheter device (102) so that the gripper arm (130) can rotate relative to the catheter device (102) to move an outer end of the gripper arm (130) away from the main body of the catheter device (102); and wherein the leaflet anchor tube (138) is arranged to implant the leaflet anchor (110) in the leaflet (12) of the heart by piercing the leaflet (12) from an atrial side of the leaflet (12).
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公开(公告)号：WO2022105054A1
公开(公告)日：2022-05-27
申请号：PCT/CN2021/072489
申请日：2021-01-18
申请人： 江苏臻亿医疗科技有限公司
发明人： 赵婧
IPC分类号： A61F2/24
摘要： 一种经房间隔植入的二尖瓣瓣膜装置，包括瓣膜假体、心室锚固件（140），瓣膜假体包括起到支撑作用的支架主体（110）以及人工瓣叶（130），人工瓣叶（130）固定于支架主体（110）的预定位置处，心室锚固件（140）包括连接部（141）及附接至心室内壁的锚固部（142），锚固部（142）通过连接部（141）固定于支架主体（110）。还提供了一种二尖瓣瓣膜装置的植入方法。瓣膜装置释放后，瓣膜假体被固定在原生瓣环处，用于替代原生瓣膜以起到打开或关闭血流通道的作用，心室锚固件（140）通过锚固部（142）与心室壁的附接作用为支架主体（110）提供牢靠的锚固力，以防止支架主体（110）被冲击到左心房。
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公开(公告)号：WO2022104013A1
公开(公告)日：2022-05-19
申请号：PCT/US2021/059075
申请日：2021-11-12
发明人： REED, Kurt Kelly
摘要： Methods and systems for providing a consistent flow of fluid through lumens of a delivery apparatus are disclosed. As one example, a delivery apparatus can include an outer shaft configured to retain a prosthetic implant in a delivery configuration, an inner shaft disposed within the outer shaft and configured to interface with an end of the prosthetic implant and move axially relative to the outer shaft, and a sleeve shaft disposed within the outer shaft and configured to cover the prosthetic implant in the delivery configuration. In some examples, the inner shaft can include one or more openings defined therein that extend between an inner surface and an outer surface of the inner shaft and that are configured to fluidly couple an inner lumen of the inner shaft with a lumen disposed between the outer surface of the inner shaft and an inner surface of the sleeve shaft.
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公开(公告)号：WO2022103794A1
公开(公告)日：2022-05-19
申请号：PCT/US2021/058723
申请日：2021-11-10
发明人： DESROSIERS, John, J.
IPC分类号： A61F2/24
摘要： Embodiments of a nosecone for a transcatheter delivery apparatus are disclosed. The nosecone can include a distal portion and a proximal portion. A longitudinal axis can extend from a distal end of the distal portion to a proximal end of the proximal portion. The proximal portion can have a shoulder region adjacent the distal portion of the nosecone and a body region proximal to the shoulder region. An outer surface of the nosecone can have a cross-sectional profile taken along the longitudinal axis of the nosecone. The cross-sectional profile of the body region can have a convex shape when viewed from a centroid of the body region.
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95.发明申请
公开(公告)号：WO2022103747A1
公开(公告)日：2022-05-19
申请号：PCT/US2021/058608
申请日：2021-11-09
IPC分类号： A61F2/24
摘要： A prosthetic heart valve can have one or more hermetic layers. The inner skirt and/or the outer skirt can comprise one or more hermetic layers, or the entire valve frame can be encapsulated within one or more hermetic layers. Each hermetic layer can be substantially nonporous or can have pores therein that are sized to discourage cellular ingrowth. The hermetic layer can prevent ingrowth of surrounding native tissue, thereby reducing pannus formation on the prosthetic leaflets. Alternatively or additionally, shapes of the leaflets of the valvular structure of the prosthetic valve and/or the coupling of the leaflets to the valve frame can be selected to avoid the incidence of stasis when implanted at a relatively low pressure gradient hemodynamic location. Such a prosthetic heart valve may reduce the risk of thrombosis.
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公开(公告)号：WO2022100849A1
公开(公告)日：2022-05-19
申请号：PCT/EP2020/082097
申请日：2020-11-13
发明人： KISS, Katharina , AGRELI, Guilherme
IPC分类号： A61F2/24
摘要： The invention relates to a self-expandable stent having a dry valve made of bovine pericardium arranged at a proximal end thereof, a skirt surrounding the dry valve at the proximal end of the stent and made of one of bovine pericardium and polyester, wherein the dry valve is configured to be rehydrated when placed in contact with a solution, and the stent comprising eyelets arranged at the proximal end of the stent for fixing the stent at a point of interest, with the point of interest comprising one of the vena cava superior and the vena cava inferior. The invention further relates to a set of stents comprising two self-expendable stents and a device for a self-expandable stent.
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公开(公告)号：WO2022099000A1
公开(公告)日：2022-05-12
申请号：PCT/US2021/058247
申请日：2021-11-05
摘要： The expandable sheaths disclosed herein include an expandable outer layer and a generally non-expandable inner layer. The outer layer is movable between a non-expanded configuration and an expanded configuration, where the outer layer/tubular layer is biased to the non-expanded configuration. Receipt of the inner layer within the central lumen of the outer layer causes the outer layer to transition from the non-expanded configuration to the expanded configuration.
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公开(公告)号：WO2022095586A1
公开(公告)日：2022-05-12
申请号：PCT/CN2021/117216
申请日：2021-09-08
申请人： 深圳市健心医疗科技有限公司
发明人： 王刚
IPC分类号： A61F2/24 , A61B17/122
摘要： 一种组织闭合器械，包括第一夹合部(10)和第二夹合部(20)，第一夹合部(10)和第二夹合部(20)用于夹合组织；第一夹合部(10)包括第一夹合臂(110)及与第一夹合臂(110)可转动连接的支撑臂(120)，支撑臂(120)包括弯曲段(123)及直伸段(124)，弯曲段(123)的一端与直伸段(124)固定连接，另一端与第一夹合臂(110)可转动连接；或者，弯曲段(123)的一端与直伸段(124)固定连接，直伸段(124)的远离弯曲段(123)的一端与第一夹合臂(110)可转动连接，第一夹合臂(110)和支撑臂(120)能在打开位置和闭合位置之间移动，当第一夹合臂(110)和支撑臂(120)位于闭合位置时，第一夹合臂(110)和第二夹合部(20)相互靠近。该组织闭合器械较容易打开。
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公开(公告)号：WO2022078526A1
公开(公告)日：2022-04-21
申请号：PCT/CN2021/129999
申请日：2021-11-11
申请人： 金仕生物科技（常熟）有限公司
IPC分类号： A61F2/24
摘要： 一种瓣膜瓣叶（1）的缝制方法及介入瓣膜，方法包括标定瓣叶（1）两侧的第一固定边（11）和瓣叶（1）底部的第二固定边（12）；将第一固定边（11）向瓣裙（2）与瓣叶（1）之间的区域翻折，并将第一固定边（11）缝制在瓣裙（2）上；使第二固定边（12）保持自由伸展的状态，并将第二固定边（12）缝制在瓣裙（2）上。通过使瓣叶（1）两侧的第一固定边（11）向瓣裙（2）与瓣叶（1）之间的区域翻折，可以通过瓣叶（1）的张力作用实现在血流正向流动时瓣叶（1）能顺利打开，又能保证血流反向流动时瓣叶（1）能迅速关闭；通过使瓣叶（1）底部的第二固定边（12）不翻折，可以有效减小瓣叶（1）的底部在缝制后的厚度，从而可以减小介入瓣膜在压缩后的位于瓣叶（1）底部的局部体积，便于将介入瓣膜装入输送系统以及将介入瓣膜向人体植入。
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公开(公告)号：WO2022077794A1
公开(公告)日：2022-04-21
申请号：PCT/CN2021/072484
申请日：2021-01-18
申请人： 上海臻亿医疗科技有限公司
IPC分类号： A61F2/24
摘要： 一种植入式假体瓣膜装置及其植入方法，包括框架主体（200），框架主体（200）包括用于固定人工瓣叶（230）的瓣叶固定部（O）、位于框架端部的第一固定部（A1），沿轴向方向，框架主体（200）还包括位于第一固定部（A1）与瓣叶固定部（O）之间的第一缓冲部（B1）以及位于框架主体（200）另一端部与瓣叶固定部（O）之间的第二缓冲部（B2），其中，第一缓冲部（B1）、第二缓冲部（B2）中的至少一者具有沿轴向方向的弹性。该假体瓣膜装置，植入目标位置后，当心脏收缩和舒张时，由于第一缓冲部（B1）或第二缓冲部（B2）具有轴向方向的弹性，因此可提供缓冲功能，瓣叶固定部（O）可以沿轴向运动，从而能够减小血流施加在框架主体（200）上的冲击力，进而能够提高框架主体（200）的耐疲劳性，提高瓣叶的耐久性。
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