公开(公告)号：WO02065086A3

公开(公告)日：2003-09-25

申请号：PCT/FR0200522

申请日：2002-02-12

申请人： TOTALFINAELF FRANCE ,  JARNAIS FREDERIC ,  BELGHAZI AHMED ,  ALBINET BENOIT ,  CHEVROT THIERRY

发明人： JARNAIS FREDERIC ,  BELGHAZI AHMED ,  ALBINET BENOIT ,  CHEVROT THIERRY

IPC分类号： G01N27/02 ,  G01N33/28 ,  G01N27/22 ,  G01N33/30

CPC分类号： G01N33/2888 ,  G01N27/026

摘要： The invention concerns a method for measuring the efficacy of a lubricant by electrochemical impedance spectroscopy, which consists in: introducing the lubricant in a measuring cell comprising two metal electrodes; feeding said electrodes with at least a variable frequency voltage; measuring the impedance of the lubricant-electrode system in the high frequency range and in the low frequency range; simulating, by means of a software, an equivalent electric circuit supplying an impedance profile coinciding with the one measured with the cell; calculating, on the basis of said simulated equivalent electric circuit, at least a first specific parameter in the high frequency range and representing the modifications in the volume characteristics of the lubricant, and at least a second specific parameter in the low frequency range and representing surface characteristics of the lubricant. The invention also concerns a device for implementing said method.

摘要翻译： 本发明涉及通过电化学阻抗谱测量润滑剂的功效的方法，该方法包括：将润滑剂引入到包括两个金属电极的测量池中; 以至少一个可变频率电压馈送所述电极; 在高频范围和低频范围内测量润滑剂 - 电极系统的阻抗; 通过软件模拟等效电路，提供与用该单元测量的阻抗曲线一致的阻抗曲线; 基于所述模拟等效电路计算高频范围中的至少第一特定参数，并表示润滑剂的体积特性的变化，以及低频范围中的至少第二特定参数，并表示表面 润滑剂的特性。 本发明还涉及一种用于实现所述方法的装置。

公开(公告)号：WO2003073089A1

公开(公告)日：2003-09-04

申请号：PCT/US2003/005810

申请日：2003-02-25

申请人： ZYOMYX, INC.

发明人： WAGNER, Peter ,  WIEGAND, Gerald

IPC分类号： G01N27/02

CPC分类号： G01N27/026 ,  G01N33/48728

摘要： A highly time resolved impedance spectroscopy that enhances the measurement of the dynamics of non-stationary systems with enhanced time resolution. The highly time resolved impedance spectroscopy includes an optimized, frequency rich a.c., or transient, voltage signal is used as the perturbation signal, non-stationary time to frequency transformation algorithms are used when processing the measured time signals of the voltage and current to determine impedance spectra which are localized in time; and the system-characterizing quantities are determined from the impedance spectra using equivalent circuit fitting in a time-resolution-optimized form. Methods and apparatus for processing impedance spectra data are also provided.

摘要翻译： 高度时间分辨的阻抗谱，增强了时间分辨率提高的非固定系统的动态测量。 高度时间分辨的阻抗谱包括优化的频率丰富的交流或瞬态电压信号用作扰动信号，当处理测量的电压和电流的时间信号以确定阻抗时，使用非平稳的时间到频率变换算法 时间局部化的光谱; 并且使用以时间分辨率优化形式的等效电路拟合从阻抗谱确定系统特征量。 还提供了用于处理阻抗谱数据的方法和装置。

公开(公告)号：WO2003031962A2

公开(公告)日：2003-04-17

申请号：PCT/US2002/029178

申请日：2002-09-13

申请人： SIGNATURE BIOSCIENCE, INC.

发明人： HEANUE, Joseph ,  JAIN, Hayuta ,  FULLER, Christopher, K. ,  LIU, Vivian, F. ,  NEHRLICH, Eric, C. ,  NILMEIER, Jerome, P.

IPC分类号： G01N27/06

CPC分类号： G01N33/96 ,  G01N27/026

摘要： A method for accurately detemining the complex permittivity of a test solution to detect molecular or cellular events occurring therein includes selecting a plurality of calibration solutions, each of which has a predetermined complex permittivity comprising a real component and an imaginary component, whereby the real or imaginary component of the complex permittivities of the calibration solutions collectively extend above and below the expected real or imaginary component of the complex permittivity of the test solution. Measurement parameters are obtained for each of the calibration solutions. A respective number of complex coefficients corresponding to the number of calibration standards are computed, each complex coefficient comprising a term in a rational function for converting measurement parameters to a complex permittivity. Measurement parameters are obtained for the test solution and applied to the rational function to determine the complex permittivity of the test solution.

摘要翻译： 用于准确地确定测试溶液以检测其中发生的分子或细胞事件的复介电常数的方法包括选择多个校准溶液，每个校准溶液具有包括实部和虚部的预定复介电常数，由此实数或虚数 校准溶液的复数介电常数的分量共同延伸到测试溶液的复介电常数的预期实部或虚部的上方和下方。 为每个校准溶液获得测量参数。 计算对应于校准标准数量的相应数量的复数系数，每个复系数包括用于将测量参数转换为复介电常数的有理函数中的项。 对测试溶液获得测量参数，并应用于合理函数以确定测试溶液的复介电常数。

公开(公告)号：WO0127605A9

公开(公告)日：2002-11-21

申请号：PCT/US0026765

申请日：2000-09-29

申请人： WIEGAND GERALD ,  SACKMANN ERICH

发明人： WIEGAND GERALD ,  SACKMANN ERICH

IPC分类号： G01N27/02 ,  G01N27/416 ,  G01R23/16 ,  G01R27/02

CPC分类号： G01R27/02 ,  G01N27/026 ,  G01R23/16

摘要： A highly time resolved impedance spectroscopy that enhances the measurement of the dynamics of non-stationary systems with enhanced time resolution. The highly time resolved impedance spectroscopy includes an optimized, frequency rich a.c., or transient, voltage signal is used as the perturbation signal, non-stationary time to frequency transformation algorithms are used when processing the measured time signals of the voltage and current to determine impedance spectra which are localized in time; and the system-charachterizing quantities are determined from the impedance spectra using equivalent circuit fitting in a time-resolution-optimized form.

摘要翻译： 高度时间分辨的阻抗谱，增强了时间分辨率提高的非固定系统的动态测量。 高度时间分辨的阻抗谱包括优化的频率丰富的交流或瞬态电压信号用作扰动信号，当处理测量的电压和电流的时间信号以确定阻抗时，使用非平稳的时间到频率变换算法 时间局部化的光谱; 并且使用以时间分辨率优化形式的等效电路拟合的阻抗谱确定系统特征量。

公开(公告)号：WO98052073A2

公开(公告)日：1998-11-19

申请号：PCT/US1998/009039

申请日：1998-05-08

IPC分类号： G01N27/02 ,  G01N27/22 ,  G01N33/28 ,  G01V3/02

CPC分类号： G01N33/2888 ,  G01N27/026

摘要： This invention relates to a fluid screening device, comprising: an impedance sensor including a cavity for holding a fluid to be screened, an impedance of the impedance sensor being affected by conditions of the fluid; an impedance measuring circuit for measuring the impedance of the impedance sensor with respect to at least one frequency; a processsor for processsing impendance data taken by the impedance measuring circuit for purposes of determining a condition of the fluid; and a connector which operatively couples the impedance sensor to the impedance measuring circuit, the connector allowing the impedance sensor to be selectively detached from the impedance measuring circuit.

摘要翻译： 本发明涉及一种流体筛选装置，包括：阻抗传感器，其包括用于保持要被筛选的流体的空腔，阻抗传感器的阻抗受流体条件的影响; 阻抗测量电路，用于测量阻抗传感器相对于至少一个频率的阻抗; 用于处理由阻抗测量电路获取的阻抗数据的处理器，用于确定流体的状况; 以及将阻抗传感器可操作地耦合到阻抗测量电路的连接器，所述连接器允许阻抗传感器从阻抗测量电路选择性地分离。

公开(公告)号：WO1994023286A1

公开(公告)日：1994-10-13

申请号：PCT/EP1994000958

申请日：1994-03-25

申请人： LANG APPARATEBAU GMBH

发明人： LANG APPARATEBAU GMBH ,  KLEIN, Joachim

IPC分类号： G01N27/02

CPC分类号： D06F39/004 ,  A47L15/4297 ,  G01N27/026 ,  G01N27/10 ,  G01N33/18

摘要： A sensor (24) for measuring the degree of soil of a wash bath has at least two electrodes (35, 36) through which the wash bath flows. An alternating voltage is applied to the electrodes (35, 36). The capacitor formed by the electrodes and the intermediate wash bath supplies measurement values (MR, MI) which correspond to the real component and to the imaginary component of the impedance. Impedance changes between a fresh bath and the used wash bath are evaluated. The moment when the wash bath is to be changed is indicated by a predetermined maximum impedance difference.

公开(公告)号：WO2019014692A1

公开(公告)日：2019-01-24

申请号：PCT/AT2018/050017

申请日：2018-07-20

申请人： NOVAPECC GMBH

发明人： BRUNAUER, Georg ,  SLOUKA, Christoph ,  HERWIG, Christoph ,  GRUBER, Alfred

IPC分类号： G01N27/02 ,  G01N33/487 ,  G01N27/22 ,  C12M1/34

CPC分类号： G01N27/026 ,  C12M41/36 ,  C12M41/46 ,  G01N27/221 ,  G01N27/226 ,  G01N33/48735

摘要： Die Erfindung betrifft ein Messverfahren zur elektrischen spektroskopischen Impedanzmessung eines lebende Zellen enthaltenden Fluids, wobei über zumindest zwei Elektroden (2) in dem Fluid angeordnet werden, und mehrere Messsignale in Form von Wechselspannungen nacheinander zwischen den Elektroden (2) angelegt und der Strom und die Spannung als Messwerte zwischen den Elektroden (2) gemessen werden, wobei dabei die Frequenzen der Wechselspannungen zumindest teilweise unterschiedlich sind. Aufgabe der Erfindung ist, ein Verfahren der beschriebenen Art bereitzustellen, mit der die Zellzahl genauer bestimmt werden kann. Dies wird dadurch gelöst, dass die spektroskopische Impedanzmessung einen Frequenzbereich von 0,1 Hz bis 10 6 Hz umfasst.

公开(公告)号：WO2018075085A1

公开(公告)日：2018-04-26

申请号：PCT/US2016/064342

申请日：2016-12-01

申请人： PURDUE RESEARCH FOUNDATION

发明人： MARINERO-CACERES, Esteban Ernesto ,  KUHN, Richard ,  STANCIU, Lia Antoaneta ,  JIN, Seonah

IPC分类号： G01N27/87 ,  G01N27/327

CPC分类号： C12Q1/6837 ,  C12Q1/6825 ,  C12Q1/701 ,  G01N27/026 ,  G01N27/3276 ,  G01N27/3278 ,  Y02A50/51 ,  Y02A50/53 ,  Y02A50/60 ,  C12Q2563/116 ,  C12Q2565/519 ,  C12Q2565/607

摘要： In one embodiment, 3-Aminopropyltriethoxysilane (APTES) functionalized graphene oxide (APTES-GO) wrapped SiO 2 particle composite (SiO 2 @APTES-GO) was prepared via the self-assembly process of APTES-GO sheets and SiO 2 particles. Transmission electron microscopy (TEM) and Attenuated Total Reflectance-Fourier Transform Infrared spectroscopy (ATR-FTIR) confirmed wrapping of the SiO 2 particles by the APTES-GO sheets. A biosensor based on electrochemical impedance spectroscopy (EIS) was constructed and used to sensitively detect dengue DNA and dengue RNA via primer hybridization using different oligonucleotide sequences. The results demonstrated that the SiO 2 @APTES-GO electrode material led to enhanced sensitivity, selectivity and detection limit, compared to both APTES-GO and APTES- S1O2. The three-dimensional structure, high surface area, electrical properties and the ability for rapid hybridization offered by the SiO 2 @APTES-GO rendered this electrode material as ideal to use in the reported dengue impedimetric sensor.

摘要翻译： 在一个实施方案中，将3-氨基丙基三乙氧基硅烷（APTES）官能化的氧化石墨烯（APTES-GO）包裹SiO 2颗粒复合物（SiO 2 @APTES -GO）是通过APTES-GO片和SiO 2颗粒的自组装过程制备的。 透射电子显微镜（TEM）和衰减全反射傅立叶变换红外光谱（ATR-FTIR）证实APTES-GO片包裹SiO 2颗粒。 构建了基于电化学阻抗谱（EIS）的生物传感器，并使用不同的寡核苷酸序列通过引物杂交灵敏地检测登革热DNA和登革热RNA。 结果表明，与APTES-GO和APTES-SiO 2相比，SiO 2APTES-GO电极材料导致增强的灵敏度，选择性和检测极限。 三维结构，高表面积，电性质和由SiO 2 APTES-GO提供的快速杂交能力使得该电极材料理想地用于所报道的登革热阻抗传感器中。 / p>

公开(公告)号：WO2017124104A1

公开(公告)日：2017-07-20

申请号：PCT/US2017/013797

申请日：2017-01-17

申请人： CASE WESTERN RESERVE UNIVERSITY

发明人： SUSTER, Michael ,  MOHSENI, Michael ,  MAJI, Debnath ,  STAVROU, Evi ,  GURKAN, Umut

IPC分类号： G01N27/22 ,  A61B5/05 ,  A61B5/145 ,  G01N27/02 ,  G01N27/06

CPC分类号： A61B5/05 ,  A61B5/145 ,  G01N27/026 ,  G01N27/08 ,  G01N27/221 ,  G01N33/4905

摘要： As one example, a fluid monitoring apparatus includes a dielectric microsensor that includes a capacitive sensing structure integrated into a microfluidic channel. The microfluidic channel includes a fluid input to receive a sample volume of a sample under test (SUT). A transmitter provides an input radio frequency (RF) signal to an RF input of the microsensor. A receiver receives an output RF signal from the microsensor. A computing device computes dielectric permittivity values of the SUT that vary over a time interval based on the output RF signal. The computing device may determine at least one permittivity parameter based on the computed dielectric permittivity values over at least a portion of the time interval.

摘要翻译： 作为一个实例，流体监测设备包括电介质微传感器，其包括集成到微流体通道中的电容传感结构。 微流体通道包括用于接收样本体积的待测样本（SUT）的流体输入。 发射机向微传感器的RF输入提供输入射频（RF）信号。 接收器接收来自微传感器的输出RF信号。 计算设备基于输出RF信号来计算SUT的介电常数值，该介电常数值在时间间隔上变化。 计算设备可以基于在时间间隔的至少一部分上计算的介电常数值来确定至少一个介电常数参数。

公开(公告)号：WO2017018934A1

公开(公告)日：2017-02-02

申请号：PCT/SG2016/050345

申请日：2016-07-21

申请人： NANYANG TECHNOLOGICAL UNIVERSITY ,  NATIONAL UNIVERSITY OF SINGAPORE

发明人： EURENIUS, Karinh Emma Josephina ,  KJELLEBERG, Lars Ake Staffan ,  LEE, Kai Wei Kelvin ,  LI, Yong Ling Adelicia ,  SOH, Zhiyan Joanne

IPC分类号： G01N33/483 ,  C12M3/04

CPC分类号： C12M41/36 ,  C12M29/06 ,  G01N27/026 ,  G01N33/4833

摘要： The invention relates generally to a device and a method for monitoring the growth of a biofilm and measuring a property of the biofilm, and in particular, to an integrated device wherein the growth and measurement of the conduction of the biofilm are performed in the same integrated device. The integrated device comprises a flow cell biofilm growth chamber entirely housed within an electrochemical impedance spectroscopy (EIS) chamber. The flow cell biofilm growth chamber comprises a working-electrode-supported substrate and the EIS chamber comprises a counter-electrode-supported substrate, wherein the two substrates are adapted for electrical connection to an external impedance measurement apparatus.

摘要翻译： 本发明一般涉及用于监测生物膜的生长并测量生物膜的性质的装置和方法，特别涉及一种集成装置，其中生物膜的生长和测量在相同的集成 设备。 该集成装置包括完全容纳在电化学阻抗谱（EIS）室内的流动池生物膜生长室。 流动池生物膜生长室包括工作电极支撑的衬底，并且EIS室包括反电极支撑衬底，其中两个衬底适于与外部阻抗测量装置电连接。