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公开(公告)号：WO2018204803A1
公开(公告)日：2018-11-08
申请号：PCT/US2018/031117
申请日：2018-05-04
发明人： SAH, Dinah, Wen-Yee , CHEN, Fen , ZHOU, Pengcheng , WANG, Xin , SHU, Yanquan , HOU, Jinzhao
IPC分类号： C12N15/09 , C12N15/11 , C12N15/113 , C12N15/86 , C12N15/861 , A61K35/76 , A61K48/00 , A61P25/14 , C12N2310/141 , C12N2320/32 , C12N2710/14144 , C12N2750/14121 , C12N2750/14123 , C12N2750/14132 , C12N2750/14143 , C12N7/00
摘要： The present invention relates to adeno-associated viral (AAV) particles encoding siRNA molecules and methods for treating Huntington's Disease (HD).
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公开(公告)号：WO2018160993A1
公开(公告)日：2018-09-07
申请号：PCT/US2018/020704
申请日：2018-03-02
发明人： SURI, Vipin , ELPEK, Kutlu Goksu , OLS, Michelle, Lynn , DOLINSKI, Brian , KOSMIDER, Nicole , HELLER, Scott, Francis , KULKARNI, Abhishek , INNISS, Mara, Christine , LI, Dan Jun
摘要： The present invention provides biocircuit systems, effector modules and compositions for cancer immunotherapy. Methods for inducing anti-cancer immune responses in a subject are also provided.
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公开(公告)号：WO2018022957A1
公开(公告)日：2018-02-01
申请号：PCT/US2017/044289
申请日：2017-07-28
摘要： The present invention relates to cancer immunotherapy. Conjugates and nanoparticles comprising T cell binding moieties that can elicit a tumor specific immune response are provided. The conjugates comprise one or more tumor cell binding moieties that are connected to the T cell binding moieties. Nanoparticles comprising the conjugates of the present invention are also provided to improve the delivery of the conjugates, and increase immunogenicity and lower toxicity.
摘要翻译： 本发明涉及癌症免疫疗法。 提供了包含可引起肿瘤特异性免疫应答的T细胞结合部分的缀合物和纳米颗粒。 缀合物包含一个或多个连接至T细胞结合部分的肿瘤细胞结合部分。 还提供了包含本发明缀合物的纳米颗粒以改善缀合物的递送，并增加免疫原性和降低毒性。
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公开(公告)号：WO2017197241A1
公开(公告)日：2017-11-16
申请号：PCT/US2017/032366
申请日：2017-05-12
摘要： Targeted constructs and pharmaceutical formulations thereof, comprising at least one conjugate of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety via an optional internal linker moiety have been designed which can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the targeted constructs and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
摘要翻译： 已经设计了靶向构建体及其药物制剂，其包含至少一种通过任选的内部连接体部分与靶向部分连接的活性剂（例如治疗剂，预防剂或诊断剂）的缀合物，其可以 提供活性剂的改善的空间递送和/或改善的生物分布。 提供了制备靶向构建体及其制剂的方法。 提供将该制剂给予有需要的受试者的方法，例如用于治疗或预防癌症或传染性疾病。
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公开(公告)号：WO2017105939A1
公开(公告)日：2017-06-22
申请号：PCT/US2016/065228
申请日：2016-12-07
发明人： DEMARCO, Steven James , ARATA, Michelle Denise , PARKER, Grace Victoria , RICARDO, Alonso , TOBE, Sylvia , TRECO, Douglas A.
CPC分类号： A61K38/12 , A61K9/0019
摘要： The present invention relates to polypeptide modulators of complement activity, including cyclic polypeptide modulators. Included are methods of utilizing such modulators as therapeutics.
摘要翻译： 本发明涉及补体活性的多肽调节剂，包括环状多肽调节剂。 包括利用这种调节剂作为治疗剂的方法。
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公开(公告)号：WO2017096162A1
公开(公告)日：2017-06-08
申请号：PCT/US2016/064616
申请日：2016-12-02
CPC分类号： C07K16/081 , C07K2319/60 , C12N15/86 , C12Q1/70
摘要： The present invention relates to improved methods and assays for the detection of adeno-associated virus (AAV) neutralizing antibodies in sera. The present invention provides safe, sensitive and high throughput neutralization assays for antibody detection. Specifically, the methods comprising incubating an AAV vector with dilutions of a serum sample to form a mixture; exposing AAV permissive cells to the mixture; measuring the amount or quantity of AAV permissive cells which have been transduced; and determining the AAV neutralizing antibody titer in the serum sample based on the measurement.
摘要翻译： 本发明涉及用于检测血清中腺伴随病毒（AAV）中和抗体的改进的方法和测定法。 本发明提供了用于抗体检测的安全，灵敏和高通量中和测定。 具体而言，所述方法包括将AAV载体与血清样品的稀释物一起孵育以形成混合物; 将AAV许可细胞暴露于混合物; 测量已转导的AAV许可细胞的量或数量; 并基于该测量确定血清样品中的AAV中和抗体效价。
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公开(公告)号：WO2017083582A1
公开(公告)日：2017-05-18
申请号：PCT/US2016/061427
申请日：2016-11-10
发明人： EAVARONE, David A. , PRENDERGAST, Jillian M. , BEHRENS, Jeffrey , LUGOVSKOY, Alexey Alexandrovich , DRANSFIELD, Daniel T.
IPC分类号： A61K39/395 , C07K16/00 , C07K16/30 , G01N33/574
CPC分类号： A61K47/6803 , A61K47/6851 , A61K2039/505 , C07K16/3092 , C07K2317/24 , C07K2317/33 , C07K2317/77 , C07K2317/92
摘要： The present invention provides glycan-interacting antibodies and methods for producing glycan-interacting antibodies useful in the treatment and prevention of human disease, including cancer. Such glycan-interacting antibodies include humanized antibodies, derivatives and fragments thereof as well as related compositions and kits. Methods of using glycan-interacting antibodies for treatment and diagnosis are included.
摘要翻译： 本发明提供了聚糖相互作用抗体以及用于产生可用于治疗和预防人类疾病（包括癌症）的聚糖相互作用抗体的方法。 此类与聚糖相互作用的抗体包括人源化抗体，其衍生物和片段以及相关组合物和试剂盒。 包括使用聚糖相互作用抗体进行治疗和诊断的方法。
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公开(公告)号：WO2017075495A1
公开(公告)日：2017-05-04
申请号：PCT/US2016/059529
申请日：2016-10-28
发明人： WOOSTER, Richard , WHALEN, Kerry , BAZINET, Patrick Rosaire , BILODEAU, Mark T. , KADIYALA, Sudhakar , PERINO, Samantha , SWERYDA-KRAWIEC, Beata , SHINDE, Rajesh R.
CPC分类号： C07K14/72
摘要： Conjugates of an active agent such as DM1 attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker, and particles comprising such conjugates have been designed. Such conjugates and particles can provide improved temporospatial delivery of the active agent, improved biodistribution and penetration in tumor, and/or decreased toxicity. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer.
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公开(公告)号：WO2017023749A1
公开(公告)日：2017-02-09
申请号：PCT/US2016/044705
申请日：2016-07-29
发明人： KADIYALA, Sudhakar , WARD, Donna T.
CPC分类号： A61K39/39 , A61K47/6883 , A61K47/6933 , A61K2039/505 , A61K2039/55516 , C07K16/2818 , C07K2317/622
摘要： The present invention relates to modulation of the tumor microenvironment to increase cancer specific immune responses. Conjugates, nanoparticles and formulations of the present invention relieve the inhibitory effect induced by tumor cells, and enhance antitumor immunity. The compostions provided herein can be used as immunotherapies, or as adjuvants used in conjunction with other immunotherapies such as peptide vaccines, cell vaccines and/or adoptive T cell transfer.
摘要翻译： 本发明涉及肿瘤微环境的调节以增加癌症特异性免疫应答。 本发明的缀合物，纳米颗粒和制剂缓解了肿瘤细胞诱导的抑制作用，提高了抗肿瘤免疫力。 本文提供的组合物可用作免疫疗法，或作为与其他免疫疗法联合使用的佐剂，例如肽疫苗，细胞疫苗和/或过继性T细胞转移。
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公开(公告)号：WO2016123371A1
公开(公告)日：2016-08-04
申请号：PCT/US2016/015412
申请日：2016-01-28
发明人： ARATA, Michelle, Denise , DHAMNASKAR, Ketki, Ashok , ELBAUM, Daniel , JOSEPHSON, Kristopher , LARSON, Kelley, Cronin , MA, Zhong , NIMS, Nathan, Ezekiel , RICARDO, Alonso , SEYB, Kathleen , TANG, Guo-Qing , TRECO, Douglas, A. , WANG, Zhaolin , YE, Ping , ZHENG, Hong , PERLMUTTER, Sarah, Jacqueline
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： A61K38/10 , A61K39/00 , C07K16/36 , C07K2317/76
摘要： The present invention provides polypeptide modulators of complement activity, including cyclic polypeptide modulators. Also provided are methods of utilizing such modulators as therapeutics.
摘要翻译： 本发明提供了补体活性的多肽调节剂，包括环状多肽调节剂。 还提供了利用这种调节剂作为治疗剂的方法。
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