公开(公告)号：WO2010108162A1

公开(公告)日：2010-09-23

申请号：PCT/US2010/028069

申请日：2010-03-19

Applicant: VERTEX PHARMACEUTICALS INCORPORATED ,  DEMATTEI, John ,  LOOKER, Adam, R. ,  NEUBERT-LANGILLE, Bobbianna ,  TRUDEAU, Martin ,  ROEPER, Stefanie ,  RYAN, Michael, P. ,  YAP, Dahrika, Milfred Lao ,  KRUEGER, Brian, R. ,  GROOTENHUIS, Peter, D.J. ,  VAN GOOR, Frederick, F. ,  BOTFIELD, Martyn, C. ,  ZLOKARNIK, Gregor

Inventor： DEMATTEI, John ,  LOOKER, Adam, R. ,  NEUBERT-LANGILLE, Bobbianna ,  TRUDEAU, Martin ,  ROEPER, Stefanie ,  RYAN, Michael, P. ,  YAP, Dahrika, Milfred Lao ,  KRUEGER, Brian, R. ,  GROOTENHUIS, Peter, D.J. ,  VAN GOOR, Frederick, F. ,  BOTFIELD, Martyn, C. ,  ZLOKARNIK, Gregor

IPC: C07D215/233

CPC classification number: C07C205/43 ,  C07C68/02 ,  C07C69/96 ,  C07C201/08 ,  C07C213/02 ,  C07C229/66 ,  C07D215/233 ,  C07D215/56 ,  G01N33/5041 ,  G01N33/6872 ,  Y02P20/55

Abstract: The invention provides a process for the preparation of a compound of Formula 1; comprising coupling a carboxylic acid of Formula 2; with an aniline of Formula 3; in the presence of a coupling agent.

Abstract translation: 本发明提供了制备式1化合物的方法; 包括偶联式2的羧酸; 与式3的苯胺; 在偶联剂存在下。

公开(公告)号：WO2009038683A3

公开(公告)日：2010-08-26

申请号：PCT/US2008010728

申请日：2008-09-15

Applicant: VERTEX PHARMA ,  DEMATTEI JOHN ,  FENG YUSHI ,  HARRISON CRISTIAN ,  LOOKER ADAM ,  MUDUNURI PRAVEEN ,  ROEPER STEFANIE ,  ZHANG YUEGANG

Inventor： DEMATTEI JOHN ,  FENG YUSHI ,  HARRISON CRISTIAN ,  LOOKER ADAM ,  MUDUNURI PRAVEEN ,  ROEPER STEFANIE ,  ZHANG YUEGANG

IPC: C07D215/233

CPC classification number: C07D215/56 ,  A61K31/47 ,  A61K45/06 ,  C07D215/233

Abstract: Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide are described herein, including crystalline forms thereof.

Abstract translation: 本文描述了固体形式的N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺，包括其结晶形式。