公开(公告)号：WO2009053741A2

公开(公告)日：2009-04-30

申请号：PCT/GB2008/050978

申请日：2008-10-22

Applicant: YORK PHARMA PLC ,  SCHMIDTS, Thomas M. ,  RUNKEL, Frank

Inventor： SCHMIDTS, Thomas M. ,  RUNKEL, Frank

CPC classification number: A61K9/0017 ,  A61K31/506 ,  A61K31/57 ,  A61K47/10 ,  A61K47/12

Abstract: The present invention relates to a pharmaceutical formulation comprising a pharmaceutically activeagent; water; a polyethylene glycol or a poloxamer; and a polyethylene glycol mono- or di-ether. Preferably the pharmaceutically active agent is an anti-fungal or anti-mycotic agent. Preferably the pharmaceutically active agent is lipophilic and/or keratinophilic. The present invention also relates to the use of the formulation in treating diseases, disorders or pathological conditions of the nail or skin, such as onychomycosis, dermatomycosis and other mycoses. The present invention also relates to a method of administering a pharmaceutically active agent to a subject by applying the formulation comprising the pharmaceutically active agent to a nail or skin of the subject. The present invention further relates to a method of preparing the formulation.

Abstract translation: 本发明涉及药物制剂，其包含药学上可接受的药物; 水; 聚乙二醇或泊洛沙姆; 和聚乙二醇单醚或二醚。 优选地，药物活性剂是抗真菌剂或抗真菌剂。 优选地，药物活性剂是亲脂性和/或角质参与的。 本发明还涉及该制剂用于治疗指甲或皮肤的疾病，病症或病理状况，例如甲真菌病，皮肤真菌病和其它真菌病。 本发明还涉及通过将包含药学活性剂的制剂施用于受试者的指甲或皮肤来向受试者施用药物活性剂的方法。 本发明还涉及制备该制剂的方法。