公开(公告)号：WO2004091532A2

公开(公告)日：2004-10-28

申请号：PCT/US2004/011631

申请日：2004-04-14

Applicant: FMC CORPORATION ,  SEWALL, Christopher, J. ,  RILEY, Peter, J. ,  BLAKEMORE, William, R.

Inventor： SEWALL, Christopher, J. ,  RILEY, Peter, J. ,  BLAKEMORE, William, R.

IPC: A61K

CPC classification number: A61K31/715 ,  A23L29/238 ,  A61K8/042 ,  A61K8/11 ,  A61K8/73 ,  A61K8/737 ,  A61K9/0056 ,  A61K9/7007 ,  A61K47/26 ,  A61K47/36 ,  A61Q11/00 ,  A61Q19/00

Abstract: The present invention is directed to a homogeneous, thermoreversible gel comprising carrageenan wherein the carrageenan has a viscosity of less than 10 cP at 75 O C when measured in a 0.10 molar aqueous sodium chloride solution containing 1.5% by weight of the carrageenan based on the weight of all components in the solution, and optionally at least one of a plasticizer, a second film former, a bulking agent, and a pH controlling agent, wherein the gel has a solids content of at least 40%. The present invention is also directed to processes for the preparation thereof, as well as to variety of products containing the gel including edible products, soft capsules, hard capsules and solid forms encapsulating powders, tablets, caplets, etc.

Abstract translation: 本发明涉及包含角叉菜胶的均匀的热可逆凝胶，其中当在含有1.5重量％角叉菜胶的0.10摩尔氯化钠水溶液中测量时，角叉菜胶在75℃下的粘度小于10cP，基于 溶液中的所有组分的重量，以及任选的增塑剂，第二成膜剂，填充剂和pH控制剂中的至少一种的重量，其中所述凝胶具有至少40％的固体含量。 本发明还涉及其制备方法，以及含有凝胶的各种产品，包括食用产品，软胶囊，硬胶囊和包封粉末，片剂，囊片等的固体形式。

公开(公告)号：WO2004091528A2

公开(公告)日：2004-10-28

申请号：PCT/US2004/011600

申请日：2004-04-14

Applicant: FMC CORPORATION ,  BALLARD, Arthur, D. ,  SEWALL, Christopher, J. ,  MODLISZEWSKI, James, J. ,  BLAKEMORE, William, R. ,  RILEY, Peter, J.

Inventor： BALLARD, Arthur, D. ,  SEWALL, Christopher, J. ,  MODLISZEWSKI, James, J. ,  BLAKEMORE, William, R. ,  RILEY, Peter, J.

IPC: A61K

CPC classification number: A61K31/715 ,  A23L29/238 ,  A61K8/042 ,  A61K8/11 ,  A61K8/73 ,  A61K8/737 ,  A61K9/0056 ,  A61K9/7007 ,  A61K47/26 ,  A61K47/36 ,  A61Q11/00 ,  A61Q19/00

Abstract: The present invention is directed to a delivery system comprising a homogenous, thermoreversible gel film, wherein the gel film comprises: (i) a film forming amount of water soluble thermoreversible alginate and optionally at least one of a plasticizer, a second film former, a bulking agent, and a pH controlling agent; and (ii) an active substance. The present invention is also directed to a process for the manufacture thereof.

Abstract translation: 本发明涉及包含均质的热可逆凝胶膜的递送系统，其中所述凝胶膜包括：（i）成膜量的水溶性热可逆藻酸盐和任选的至少一种增塑剂，第二成膜剂， 填充剂和pH控制剂; 和（ii）活性物质。 本发明还涉及其制造方法。