公开(公告)号：WO2004091539A3

公开(公告)日：2005-05-06

申请号：PCT/US2004011908

申请日：2004-04-14

Applicant: FMC CORP ,  BALLARD ARTHUR D ,  SEWALL CHRISTOPHER J ,  MODLISZEWSKI JAMES J ,  BLAKEMORE WILLIAM R ,  RILEY PETER J

Inventor： BALLARD ARTHUR D ,  SEWALL CHRISTOPHER J ,  MODLISZEWSKI JAMES J ,  BLAKEMORE WILLIAM R ,  RILEY PETER J

IPC: A01N43/04 ,  A61K20060101 ,  A61K8/11 ,  A61K8/73 ,  A61K9/00 ,  A61K9/14 ,  A61K9/48 ,  A61K31/715 ,  A61K31/737 ,  A61K47/00 ,  A61Q19/00 ,  A61Q90/00 ,  B01F5/02

CPC classification number: A61K31/715 ,  A23L29/238 ,  A61K8/042 ,  A61K8/11 ,  A61K8/73 ,  A61K8/737 ,  A61K9/0056 ,  A61K9/7007 ,  A61K47/26 ,  A61K47/36 ,  A61Q11/00 ,  A61Q19/00

Abstract: A fluid mixing apparatus (10) for mixing fluids with steam to form gels, gel films, films and/or shaped articles includes a steam inlet (22) for injecting steam (2) into a mixing zone, and multiple fluid inlets (42, 44) for separately delivering fluids (4, 6) a mixing chamber (52). The resulted mixture can be formed into a homogenous film suitable for soft capsules, hard capsules and other film products, or formed into a shaped article.

Abstract translation: 用于将流体与蒸汽混合以形成凝胶，凝胶膜，膜和/或成形制品的流体混合装置（10）包括用于将蒸汽（2）注入混合区的蒸汽入口（22）和多个流体入口（42， 44），用于分开输送流体（4,6）混合室（52）。 所得到的混合物可以形成适合于软胶囊，硬胶囊和其它薄膜产品的均匀薄膜，或形成成型制品。

公开(公告)号：WO2004091530B1

公开(公告)日：2005-04-21

申请号：PCT/US2004011602

申请日：2004-04-14

Applicant: FMC CORP ,  MODLISZEWSKI JAMES J ,  BALLARD ARTHUR D ,  SEWALL CHRISTOPHER J ,  BLAKEMORE WILLIAM R ,  RILEY PETER J

Inventor： MODLISZEWSKI JAMES J ,  BALLARD ARTHUR D ,  SEWALL CHRISTOPHER J ,  BLAKEMORE WILLIAM R ,  RILEY PETER J

IPC: A01N43/04 ,  A61K20060101 ,  A61K8/11 ,  A61K8/73 ,  A61K9/00 ,  A61K9/14 ,  A61K9/48 ,  A61K31/715 ,  A61K31/737 ,  A61K47/00 ,  A61Q19/00 ,  A61Q90/00 ,  B01F5/02

CPC classification number: A61K31/715 ,  A23L29/238 ,  A61K8/042 ,  A61K8/11 ,  A61K8/73 ,  A61K8/737 ,  A61K9/0056 ,  A61K9/7007 ,  A61K47/26 ,  A61K47/36 ,  A61Q11/00 ,  A61Q19/00

Abstract: The present invention is directed to a homogeneous, thermoreversible gel film comprising a film forming amount of kappa-2 carrageenan, and optionally at least one of a plasticizer, a second film former, a bulking agent, and a pH controlling agent; and processes for the preparation thereof. The present invention is also directed to soft capsules and solid forms containing the gel film, as well as processes for the preparation thereof.

Abstract translation: 本发明涉及包含成膜量的κ-2角叉菜胶和任选的增塑剂，第二成膜剂，填充剂和pH控制剂中的至少一种的均匀热可逆凝胶膜; 和它们的制备方法。 本发明还涉及含有凝胶膜的软胶囊和固体形式，以及其制备方法。

公开(公告)号：WO2004091538A3

公开(公告)日：2005-04-07

申请号：PCT/US2004011907

申请日：2004-04-14

Applicant: FMC CORP ,  MODLISZEWSKI JAMES J ,  BALLARD ARTHUR D ,  SEWALL CHRISTOPHER J ,  BLAKEMORE WILLIAM R ,  RILEY PETER J

Inventor： MODLISZEWSKI JAMES J ,  BALLARD ARTHUR D ,  SEWALL CHRISTOPHER J ,  BLAKEMORE WILLIAM R ,  RILEY PETER J

IPC: A01N43/04 ,  A61K20060101 ,  A61K8/11 ,  A61K8/73 ,  A61K9/00 ,  A61K9/14 ,  A61K9/48 ,  A61K31/715 ,  A61K31/737 ,  A61K47/00 ,  A61Q19/00 ,  A61Q90/00 ,  B01F5/02

CPC classification number: A61K31/715 ,  A23L29/238 ,  A61K8/042 ,  A61K8/11 ,  A61K8/73 ,  A61K8/737 ,  A61K9/0056 ,  A61K9/7007 ,  A61K47/26 ,  A61K47/36 ,  A61Q11/00 ,  A61Q19/00

Abstract: The present invention is directed to a homogeneous, thermoreversible gel film comprising a film forming amount of a water soluble, thermoreversible alginate, and optionally at least one of a plasticizer, a second film former, a bulking agent, and a pH controlling agent; and processes for the preparation thereof. The present invention is also directed to soft capsules and solid forms containing the gel film, as well as processes for the preparation thereof.

Abstract translation: 本发明涉及均匀的热可逆凝胶膜，其包含成膜量的水溶性，热可逆藻酸盐，以及任选的增塑剂，第二成膜剂，填充剂和pH控制剂中的至少一种; 及其制备方法。 本发明还涉及含有凝胶膜的软胶囊和固体形式，以及其制备方法。

公开(公告)号：WO2004091527A2

公开(公告)日：2004-10-28

申请号：PCT/US2004011561

申请日：2004-04-14

Applicant: FMC CORP ,  BALLARD ARTHUR D ,  SEWALL CHRISTOPHER ,  MODLISZEWSKI JAMES J ,  BLAKEMORE WILLIAM R ,  RILEY PETER J

Inventor： BALLARD ARTHUR D ,  SEWALL CHRISTOPHER ,  MODLISZEWSKI JAMES J ,  BLAKEMORE WILLIAM R ,  RILEY PETER J

IPC: A01N43/04 ,  A61K20060101 ,  A61K8/11 ,  A61K8/73 ,  A61K9/00 ,  A61K9/14 ,  A61K9/48 ,  A61K31/715 ,  A61K31/737 ,  A61K47/00 ,  A61Q19/00 ,  A61Q90/00 ,  B01F5/02 ,  A61K

CPC classification number: A61K31/715 ,  A23L29/238 ,  A61K8/042 ,  A61K8/11 ,  A61K8/73 ,  A61K8/737 ,  A61K9/0056 ,  A61K9/7007 ,  A61K47/26 ,  A61K47/36 ,  A61Q11/00 ,  A61Q19/00

Abstract: The present invention is directed to a delivery system comprising a homogeneous, thermoreversible gel film, wherein the gel film comprises: (i) a film forming amount of low viscosity polymannan gum, e.g., low viscosity guar gum, and optionally at least one of a plasticizer, a second film former, a bulking agent, and a pH controlling agent; and (ii) an active substance. The present invention is also directed to a process for the manufacture thereof.

Abstract translation: 本发明涉及包含均质的热可逆凝胶膜的递送系统，其中凝胶膜包括：（i）成膜量低的聚甘露糖，例如低粘度瓜尔胶，以及任选的至少一种 增塑剂，第二成膜剂，填充剂和pH控制剂; 和（ii）活性物质。 本发明还涉及其制造方法。

公开(公告)号：WO0248199A3

公开(公告)日：2002-08-15

申请号：PCT/US0147020

申请日：2001-12-10

Applicant: FMC CORP ,  TSAI ALBERT G ,  LEDWITH LINNEA K S ,  KOPESKY ROBERT ,  LYNCH MAURICE GERARD ,  BLAKEMORE WILLIAM ROSS ,  RILEY PETER J

Inventor： TSAI ALBERT G ,  LEDWITH LINNEA K S ,  KOPESKY ROBERT ,  LYNCH MAURICE GERARD ,  BLAKEMORE WILLIAM ROSS ,  RILEY PETER J

IPC: A23L29/20 ,  A61K8/64 ,  A61K8/73 ,  A61K8/96 ,  A61K8/97 ,  A61K9/48 ,  A61Q11/00 ,  C08B37/00 ,  C08B37/12 ,  A61K7/16 ,  A61K7/26

CPC classification number: C07H13/12 ,  A61K8/73 ,  A61K9/4816 ,  A61Q11/00 ,  C08B37/0042

Abstract: The methods of the present invention prepare carrageenan products from processed seaweed material having a solids content of less than 25% by weight solids, using shear stress treatment. The carrageenan products comprise at least about 60% by weight of carrageenan and at least about 2% by weight of acid insoluble material. The carrageenan products of the present invention are useful as components in food products, such as, dairy products, meats, and dessert gels as well as non-food products, such as, toothpaste formulations, cosmetics, paints, films and delivery capsules.

Abstract translation: 本发明的方法使用剪切应力处理来由加工的海藻材料制备具有小于25重量％固体的固体含量的卡拉胶产品。 角叉菜胶产品包含至少约60重量％的角叉菜胶和至少约2重量％的酸不溶性物质。 本发明的卡拉胶产品可用作食品例如乳制品，肉类和甜点凝胶以及非食品产品例如牙膏配方，化妆品，涂料，薄膜和递送胶囊中的组分。

公开(公告)号：WO2007103209A2

公开(公告)日：2007-09-13

申请号：PCT/US2007/005436

申请日：2007-03-01

Applicant: FMC BIOPOLYMER AS ,  FMC CORPORATION ,  GASEROD, Olav ,  ANDERSEN, Therese ,  MELVIK, Jan, Egil ,  DORNISH, Michael ,  RILEY, Peter, J.

Inventor： GASEROD, Olav ,  ANDERSEN, Therese ,  MELVIK, Jan, Egil ,  DORNISH, Michael ,  RILEY, Peter, J.

IPC: A61L27/20 ,  A61L27/38 ,  A61L27/48

CPC classification number: A61L27/56 ,  A61K9/122 ,  A61K47/36 ,  A61L27/20 ,  A61L27/38 ,  A61L27/48

Abstract: The invention relates to composites comprising a polysaccharide gelled within pores of a foam, methods of preparation, and uses thereof, for example, in biomedical applications such as cell culture media and implants, controlled release delivery systems, food applications, industrial applications, and personal care applications such as cosmetic and oral hygiene. The composites of the present invention are simple to formulate using few steps and are useful for entrapping heat-sensitive components, such as cells, drugs, flavors or fragrances within the polysaccharide gel. In addition, the invention provides for a composite able to gently immobilize fragile components, such as living cells, without exposing such components to shear forces.

Abstract translation: 本发明涉及包含在泡沫的孔内凝胶化的多糖的复合材料，制备方法及其用途，例如在生物医学应用中，例如细胞培养基和植入物，控制释放递送系统，食品应用，工业应用和个人 护理应用如化妆品和口腔卫生。 本发明的复合材料使用几个步骤简单的配制，并且可用于在多糖凝胶内捕获热敏组分如细胞，药物，香料或香料。 此外，本发明提供了一种复合材料，其能够轻柔地固定易碎组分如活细胞，而不会使这些组分暴露于剪切力。

公开(公告)号：WO2004091530A3

公开(公告)日：2005-03-03

申请号：PCT/US2004011602

申请日：2004-04-14

Applicant: FMC CORP ,  MODLISZEWSKI JAMES J ,  BALLARD ARTHUR D ,  SEWALL CHRISTOPHER J ,  BLAKEMORE WILLIAM R ,  RILEY PETER J

Inventor： MODLISZEWSKI JAMES J ,  BALLARD ARTHUR D ,  SEWALL CHRISTOPHER J ,  BLAKEMORE WILLIAM R ,  RILEY PETER J

IPC: A01N43/04 ,  A61K20060101 ,  A61K8/11 ,  A61K8/73 ,  A61K9/00 ,  A61K9/14 ,  A61K9/48 ,  A61K31/715 ,  A61K31/737 ,  A61K47/00 ,  A61Q19/00 ,  A61Q90/00 ,  B01F5/02

CPC classification number: A61K31/715 ,  A23L29/238 ,  A61K8/042 ,  A61K8/11 ,  A61K8/73 ,  A61K8/737 ,  A61K9/0056 ,  A61K9/7007 ,  A61K47/26 ,  A61K47/36 ,  A61Q11/00 ,  A61Q19/00

Abstract: The present invention is directed to a homogeneous, thermoreversible gel film comprising a film forming amount of kappa-2 carrageenan, and optionally at least one of a plasticizer, a second film former, a bulking agent, and a pH controlling agent; and processes for the preparation thereof. The present invention is also directed to soft capsules and solid forms containing the gel film, as well as processes for the preparation thereof.

Abstract translation: 本发明涉及包含成膜量的κ-2角叉菜胶和任选的增塑剂，第二成膜剂，填充剂和pH控制剂中的至少一种的均匀的热可逆凝胶膜; 及其制备方法。 本发明还涉及含有凝胶膜的软胶囊和固体形式，以及其制备方法。

公开(公告)号：WO2004091539A2

公开(公告)日：2004-10-28

申请号：PCT/US2004/011908

申请日：2004-04-14

Applicant: FMC CORPORATION ,  BALLARD, Arthur, D. ,  SEWALL, Christopher, J. ,  MODLISZEWSKI, James, J. ,  BLAKEMORE, William, R. ,  RILEY, Peter, J.

Inventor： BALLARD, Arthur, D. ,  SEWALL, Christopher, J. ,  MODLISZEWSKI, James, J. ,  BLAKEMORE, William, R. ,  RILEY, Peter, J.

IPC: A61K

CPC classification number: A61K31/715 ,  A23L29/238 ,  A61K8/042 ,  A61K8/11 ,  A61K8/73 ,  A61K8/737 ,  A61K9/0056 ,  A61K9/7007 ,  A61K47/26 ,  A61K47/36 ,  A61Q11/00 ,  A61Q19/00

Abstract: A fluid mixing apparatus for mixing fluids with steam to form gels, gel films, films and/or shaped articles includes a steam inlet for injecting steam into a mixing zone, and multiple fluid inlets for separately delivering incompatible fluids to the mixing zone. As an example, a first fluid may be a solution of one or more starches and water, and the second fluid may be a solution of one or more plasticizers and one or more hydrocolloids. Upon mixing with steam, the resulting flowable molten mass or slurry mixture can be formed into a homogeneous film that is suitable for producing soft capsules, hard capsules and other film products, or formed into a shaped article.

Abstract translation: 用于将流体与蒸汽混合以形成凝胶，凝胶膜，膜和/或成形制品的流体混合装置包括用于将蒸汽注入混合区域的蒸汽入口和用于将不相容的流体单独输送到混合区域的多个流体入口。 作为示例，第一流体可以是一种或多种淀粉和水的溶液，并且第二流体可以是一种或多种增塑剂和一种或多种水胶体的溶液。 在与蒸汽混合时，所得到的可流动的熔融物质或浆料混合物可以形成为适合于生产软胶囊，硬胶囊和其它薄膜产品或形成成型制品的均匀薄膜。

公开(公告)号：WO2004091537A2

公开(公告)日：2004-10-28

申请号：PCT/US2004011906

申请日：2004-04-14

Applicant: FMC CORP ,  BALLARD ARTHUR D ,  SEWALL CHRISTOPHER J ,  MODLISZEWSKI JAMES J ,  BLAKEMORE WILLIAM R ,  RILEY PETER J

Inventor： BALLARD ARTHUR D ,  SEWALL CHRISTOPHER J ,  MODLISZEWSKI JAMES J ,  BLAKEMORE WILLIAM R ,  RILEY PETER J

IPC: A01N43/04 ,  A61K20060101 ,  A61K8/11 ,  A61K8/73 ,  A61K9/00 ,  A61K9/14 ,  A61K9/48 ,  A61K31/715 ,  A61K31/737 ,  A61K47/00 ,  A61Q19/00 ,  A61Q90/00 ,  B01F5/02 ,  A61K

CPC classification number: A61K31/715 ,  A23L29/238 ,  A61K8/042 ,  A61K8/11 ,  A61K8/73 ,  A61K8/737 ,  A61K9/0056 ,  A61K9/7007 ,  A61K47/26 ,  A61K47/36 ,  A61Q11/00 ,  A61Q19/00

Abstract: The present invention is directed to a process for making homogeneous, thermoreversible gel films comprising the steps of: (i) heating, hydrating, mixing, solubilizing, and, optionally, de-aerating a high solids, low moisture film forming composition in an apparatus providing sufficient shear, temperature and residence time to form a homogeneous molten composition, wherein the temperature is at or above the solubilizing temperature of said composition; (ii) feeding the molten composition into at least one of a mixer, pump or devolatilizer; and (iii) cooling the homogeneous molten composition at or below its gelling temperature to form said gel films. The present invention is also directed to various products made from such films, such as the gel films themselves, soft capsules, solid dosage forms and delivery systems.

Abstract translation: 本发明涉及一种制备均匀的热可逆凝胶膜的方法，包括以下步骤：（i）在装置中加热，水合，混合，增溶和任选地使高固体，低水分成膜组合物脱气 提供足够的剪切，温度和停留时间以形成均匀的熔融组合物，其中温度等于或高于所述组合物的溶解温度; （ii）将熔融组合物进料到混合器，泵或脱挥器中的至少一个中; 和（iii）在等于或低于其凝胶化温度下冷却均匀的熔融组合物以形成所述凝胶膜。 本发明还涉及由这样的膜制成的各种产品，例如凝胶膜本身，软胶囊，固体剂型和递送系统。

公开(公告)号：WO2004091532A2

公开(公告)日：2004-10-28

申请号：PCT/US2004/011631

申请日：2004-04-14

Applicant: FMC CORPORATION ,  SEWALL, Christopher, J. ,  RILEY, Peter, J. ,  BLAKEMORE, William, R.

Inventor： SEWALL, Christopher, J. ,  RILEY, Peter, J. ,  BLAKEMORE, William, R.

IPC: A61K

CPC classification number: A61K31/715 ,  A23L29/238 ,  A61K8/042 ,  A61K8/11 ,  A61K8/73 ,  A61K8/737 ,  A61K9/0056 ,  A61K9/7007 ,  A61K47/26 ,  A61K47/36 ,  A61Q11/00 ,  A61Q19/00

Abstract: The present invention is directed to a homogeneous, thermoreversible gel comprising carrageenan wherein the carrageenan has a viscosity of less than 10 cP at 75 O C when measured in a 0.10 molar aqueous sodium chloride solution containing 1.5% by weight of the carrageenan based on the weight of all components in the solution, and optionally at least one of a plasticizer, a second film former, a bulking agent, and a pH controlling agent, wherein the gel has a solids content of at least 40%. The present invention is also directed to processes for the preparation thereof, as well as to variety of products containing the gel including edible products, soft capsules, hard capsules and solid forms encapsulating powders, tablets, caplets, etc.

Abstract translation: 本发明涉及包含角叉菜胶的均匀的热可逆凝胶，其中当在含有1.5重量％角叉菜胶的0.10摩尔氯化钠水溶液中测量时，角叉菜胶在75℃下的粘度小于10cP，基于 溶液中的所有组分的重量，以及任选的增塑剂，第二成膜剂，填充剂和pH控制剂中的至少一种的重量，其中所述凝胶具有至少40％的固体含量。 本发明还涉及其制备方法，以及含有凝胶的各种产品，包括食用产品，软胶囊，硬胶囊和包封粉末，片剂，囊片等的固体形式。