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    THERAPEUTIC LASER SYSTEM OPERATING BETWEEN 1000NM AND 1300NM
    12.
    发明申请
    THERAPEUTIC LASER SYSTEM OPERATING BETWEEN 1000NM AND 1300NM 审中-公开
    治疗激光系统在1000NM和1300NM之间工作

    公开(公告)号：WO0174230B1

    公开(公告)日：2002-06-27

    申请号：PCT/US0110238

    申请日：2001-03-30

    Applicant: CERAMOPTEC IND INC

    Inventor： NEUBERGER WOLFGANG ,  SCHWARZMAIER H-J

    IPC: A61B17/00 ,  A61B18/00 ,  A61B18/20 ,  A61B18/22 ,  A61N5/06 ,  A61N5/067

    CPC classification number: A61B18/22 ,  A61B2017/00084 ,  A61B2018/00005 ,  A61B2018/2211 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0659 ,  A61N2005/067

    Abstract: Laser systems medical or cosmetic applications, comprising diode lasers or diode lasers with other solid state lasers which can deliver up to 30 cw or more, and which generally operate at a wavelength within the range of 1000 to 1300nm are presented. Individual emitter or emitter groups within the diode laser system can be powered independently. These laser systems provide maximum penetration depths for procedures such as Laser-induced Interstitial Tumor Therapy, alone or in conjunction with other therapies such as Photo-Dynamic Therapy, chemotherapy, or radiation therapy. Where beneficial for the procedure, the operating wavelength of the system can be changed without interruption. In some variants, active tissue cooling at the distal end of the delivery fibers is incorporated as well as individual feedback loops to control and stabilize the temperature induced in the tissue. To enhance thermal or photo effects and thereby increase efficiencies, absorbers can be administered and the laser system tuned to the specific absorption band of the absorber.

    Abstract translation: 激光系统医疗或化妆品应用，包括二极管激光器或二极管激光器与其他固态激光器可以提供高达30cw或更多，并且通常在1000-1300nm范围内的波长下工作。 二极管激光系统内的单个发射器或发射器组可独立供电。 这些激光系统为诸如激光诱导的间质肿瘤治疗之类的手术提供了最大穿透深度，单独或与诸如光动力疗法，化学疗法或放射疗法之类的其他疗法相结合。 在有利于程序的地方，系统的工作波长可以不中断地改变。 在一些变体中，并入输送纤维远端的活性组织冷却以及单独的反馈回路以控制和稳定组织中诱发的温度。 为了增强热效应或光效应并由此提高效率，可以施用吸收剂，并将激光系统调谐至吸收剂的特定吸收带。

    APPARATUS AND METHOD OF PHOTO-SPECIFIC TISSUE TREATMENT
    13.
    发明申请
    APPARATUS AND METHOD OF PHOTO-SPECIFIC TISSUE TREATMENT 审中-公开
    照片特异性组织治疗的装置和方法

    公开(公告)号：WO00044294A1

    公开(公告)日：2000-08-03

    申请号：PCT/US2000/002136

    申请日：2000-01-28

    IPC: A61B18/00 ,  A61B18/18 ,  A61B18/22 ,  A61C1/00 ,  G02B6/42

    CPC classification number: A61B18/00 ,  A61B2018/1807 ,  A61B2018/2211 ,  A61C1/0046 ,  G02B6/4298

    Abstract: An apparatus and related method are disclosed for directing a continuous or pulsed, polychromatic light beam through a hand-held light guide at a target biological tissue, as part of a health-related treatment in medicine or dentistry. The non-laser polychromatic light beam can be pulsed at a duration and duty cycle selected to provide optimal heating of the target issue, e.g., to temperatures in the range of 37 DEG to 175 DEG C, while allowing the tissue to undergo a thermal relaxation response between successive pulses. The treatment delivers a photo-specific energy density in the range of 10 to 5000 watts/cm2, selected to achieve the desired treatment. In the case of dental procedures on hard dental tissue, such treatments can include tooth bleaching, curing of dental composite materials, detecting of caries, cutting of enamel, dentin and bone, desensitizing of dentin, etching of enamel, osteoplasty, ostectomy, shade matching and other cosmetic procedures, trans-illumination, imaging and/or illumination.

    Abstract translation: 公开了一种设备和相关方法，用于将连续或脉冲的多色光束通过目标生物组织上的手持光导，作为医学或牙科中的健康相关治疗的一部分。 非激光多色光束可以在选定的持续时间和占空比下被脉冲以提供目标问题的最佳加热，例如，在37℃至175℃范围内的温度，同时允许组织经历热松弛 连续脉冲之间的响应。 该处理提供10至5000瓦特/平方厘米范围内的光特定能量密度，以实现所需的处理。 在硬牙组织的牙科手术的情况下，这种治疗可以包括牙齿漂白，牙科复合材料的固化，龋齿的检测，牙釉质，牙本质和骨的切割，牙本质的脱敏，牙釉质的蚀刻，成骨术，骨切除术，阴影匹配 和其他美容程序，反照明，成像和/或照明。

    APPLICATION OF LIGHT AT PLURAL TREATMENT SITES WITHIN A TUMOR TO INCREASE THE EFFICACY OF LIGHT THERAPY
    14.
    发明申请
    APPLICATION OF LIGHT AT PLURAL TREATMENT SITES WITHIN A TUMOR TO INCREASE THE EFFICACY OF LIGHT THERAPY 审中-公开
    在肿瘤中应用轻度的治疗台，以提高治疗效果

    公开(公告)号：WO99066988A1

    公开(公告)日：1999-12-29

    申请号：PCT/US1999/009582

    申请日：1999-04-30

    IPC: A61B18/22 ,  A61N5/06

    CPC classification number: A61N5/062 ,  A61B2018/2211 ,  A61B2018/2261 ,  A61N5/0601 ,  A61N2005/0652

    Abstract: Light is administered during photodynamic therapy (PDT) for an extended period of time at a plurality of sites (52) distributed within the abnormal tissue of a tumor (22). A clinical study has shown that a substantially greater volume of abnormal tissue in a tumor is destroyed by the extended administration of light therapy from a plurality of probes (50a-50e) than would have been expected based upon the teaching of the prior art. In this process, a plurality of light emitting optical fibers or probes are deployed in a spaced apart array. The greater volume of necrosis (38) in the tumor (22) is achieved due to one or more concomitant effects, including the inflammation of damaged abnormal tissue, and resultant immunological response of the patient's body; and the collapse of the vascular system that provides oxygenated blood to portions of the tumor outside the expected fluency zone.

    Abstract translation: 光在光动力学治疗（PDT）期间在分布在肿瘤（22）的异常组织内的多个位点（52）处长时间施用。 临床研究已经表明，通过从多个探针（50a-50e）的光疗法的延长施用而比基于现有技术的教导所预期的更大体积的肿瘤中的异常组织被破坏。 在该过程中，多个发光光纤或探针以间隔开的阵列展开。 由于一种或多种伴随的作用，包括损伤的异常组织的炎症和由此导致的患者身体的免疫应答，肿瘤（22）中的坏死体积（38）达到了。 以及向期望的流感区域外的部分肿瘤提供氧合血液的血管系统的崩溃。

    PHOTOACOUSTIC REMOVAL OF OCCLUSIONS FROM BLOOD VESSELS
    15.
    发明申请
    PHOTOACOUSTIC REMOVAL OF OCCLUSIONS FROM BLOOD VESSELS 审中-公开
    从血管中摄取血液中的光化学物质

    公开(公告)号：WO99020189A1

    公开(公告)日：1999-04-29

    申请号：PCT/US1998/020600

    申请日：1998-09-29

    IPC: A61B17/22 ,  A61B18/20 ,  A61B18/22 ,  A61B18/24 ,  A61N5/06 ,  A61B17/36

    CPC classification number: A61B18/245 ,  A61B2018/20359 ,  A61B2018/2211

    Abstract: Partial or total occlusions of fluid passages within the human body are removed by positioning an array of optical fibers in the passage and directing treatment radiation pulses along the fibers, one at a time, to generate a shock wave and hydrodynamic flows that strike and emulsify the occlusions. A preferred application is the removal of blood clots (thrombi and emboli) from small cerebral vessels to reverse the effects of an ischemic stroke. The operating parameters and techniques are chosen to minimize the amount of heating of the fragile cerebral vessel walls occurring during this photoacoustic treatment. One such technique is the optical monitoring of the existence of hydrodynamic flow generating vapor bubbles when they are expected to occur and stopping the heat generating pulses propagated along an optical fiber that is not generating such bubbles.

    Abstract translation: 通过将光纤阵列定位在通道中并沿着纤维一次一个地引导处理辐射脉冲来去除人体内的流体通道的部分或完全闭塞，产生冲击波和流体动力学流动，其冲击和乳化 闭塞。 优选的应用是从小脑血管移除血块（血栓和栓塞）以逆转缺血性卒中的作用。 选择操作参数和技术以最小化在该光声处理期间发生的脆弱的脑血管壁的加热量。 一种这样的技术是当期望发生流体动力学流动产生蒸汽气泡的存在并且阻止沿着不产生这种气泡的光纤传播的发热脉冲时的光学监测。

    SURGICAL LASER SYSTEMS AND LASER DEVICES
    17.
    发明申请
    SURGICAL LASER SYSTEMS AND LASER DEVICES 审中-公开
    手术激光系统和激光装置

    公开(公告)号：WO2016077678A1

    公开(公告)日：2016-05-19

    申请号：PCT/US2015/060547

    申请日：2015-11-13

    Applicant: BOSTON SCIENTIFIC SCIMED, INC.

    Inventor： YU, Honggang ,  XUAN, Rongwei, Jason ,  ZHANG, Jian, James ,  HORN, David, N. ,  YANG, Xirong ,  HASENBERG, Thomas

    IPC: A61B18/20 ,  A61B1/00 ,  A61B18/22

    CPC classification number: A61B18/24 ,  A61B18/20 ,  A61B18/22 ,  A61B2018/00172 ,  A61B2018/00642 ,  A61B2018/00982 ,  A61B2018/2035 ,  A61B2018/2211 ,  A61B2018/2244

    Abstract: A surgical laser system includes an array of laser diodes that are configured to output laser energy, a fiber bundle, a delivery fiber, and a tubular sheath. The fiber bundle includes a plurality of optical fibers and has a proximal end that is configured to receive laser energy from the array of laser diodes. The delivery fiber includes a proximal end that is configured to receive laser energy from a distal end of the fiber bundle. The tubular sheath defines a lumen, in which at least a portion of the delivery fiber is disposed. The tubular sheath is insertable into a working channel of an endoscope or a cystoscope. A distal end of the tubular sheath is configured to deliver laser energy discharged from the delivery fiber into a body of a patient.

    Abstract translation: 外科激光系统包括被配置为输出激光能量的激光二极管阵列，纤维束，递送纤维和管状护套。 纤维束包括多根光纤，并且具有被配置为从激光二极管阵列接收激光能量的近端。 递送纤维包括被配置为从纤维束的远端接收激光能量的近端。 管状护套限定内腔，其中布置至少一部分递送纤维。 管状护套可插入到内窥镜或膀胱镜的工作通道中。 管状护套的远端构造成将从输送纤维排出的激光能量输送到患者体内。

    LASER ASSISTED THROMBOLYSIS
    19.
    发明申请
    LASER ASSISTED THROMBOLYSIS 审中-公开
    激光辅助血栓形成

    公开(公告)号：WO2015034840A8

    公开(公告)日：2015-05-28

    申请号：PCT/US2014053743

    申请日：2014-09-02

    Applicant: GROSS JUSTUS ,  SPECTRANETICS CORP

    Inventor： GROSS JUSTUS

    IPC: A61B18/24 ,  A61M31/00

    CPC classification number: A61B18/245 ,  A61B18/14 ,  A61B2018/0022 ,  A61B2018/00285 ,  A61B2018/0041 ,  A61B2018/00577 ,  A61B2018/00982 ,  A61B2018/1861 ,  A61B2018/2211 ,  A61B2218/001 ,  A61M25/0026 ,  A61M2025/0031 ,  A61M2025/004 ,  A61N7/00

    Abstract: The present disclosure relates to methods and systems for removing a vascular obstruction in a subject using a combination ofthrombolytic and laser ablation therapy. Treatment methods include positioning a catheter adjacent to an obstruction within a vessel of a subject. A portion of the obstruction may be ablated by delivering laser energy through the optical fibers to the distal end of the catheter, where the optical fibers are exposed, and circulating a fluid containing one or more thrombolytic agents to a remaining portion of the obstruction for a predetermined amount time. Fluid containing one or more thrombolytic agents capable of dissolving a remaining portion of the obstruction may be circulated through the fluid delivery lumen and removed through the fluid removal lumen.

    Abstract translation: 本公开涉及使用溶栓和激光消融治疗的组合来去除受试者中的血管阻塞的方法和系统。 治疗方法包括将导管邻近受试者血管内的梗阻定位。 障碍物的一部分可以通过将激光能量通过光纤传递到导管的远端而消融，其中光纤被暴露，并且将含有一种或多种溶栓剂的流体循环到阻塞物的剩余部分 预定时间。 含有一种或多种能够溶解阻塞物的剩余部分的溶栓剂的流体可循环通过流体输送腔并通过流体移除管腔移除。

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