公开(公告)号：WO2004046165A2

公开(公告)日：2004-06-03

申请号：PCT/US2003/036184

申请日：2003-11-14

Applicant: ZENGEN, INC. ,  LIPTON, James, M.

Inventor： LIPTON, James, M.

IPC: C07K

CPC classification number: A61K38/34 ,  A61K9/0048

Abstract: The present invention discloses a method of treating ophthalmic conditions by administering to a vertebrateinflicted with the condition a therapeutically effective amount of a peptide which is derived from alpha-melanocyte-stimulating hormone (a-MSH) and biologically functional equivalents thereof. Specifically,the peptides derived from alpha-melanocyte-stimulating hormone (a-MSH) include a-MSH (1-13) which is SYSMEHFRWGKPV (SEQ. ID NO. 4), a-MSH (4-10) which is MEHFRWG (SEQ. ID NO. 2), a-MSH (6-13)which is HFRWGKPV (SEQ. ID NO. 3), a-MSH (11-13) which is KPV (SEQ. ID NO. 1), and a KPV dimer(SEQ. ID NO. 5). The ophthalmic condition can be the result of an on going insult such as "Computer Eyes"or an acute or chronic infection of the eyes. The infective organism can be caused by a microorganism,which includes a bacteria, a fungi or a virus. The vertebrate includes a bird and a mammal. The peptidehas antipyretic, anti-inflammatory, anti-bacterial, antifungal, and antiviral properties and therefore can be administered at the onset of the ophthalmic condition before the insult causing the condition is determinedas well as thereafter.

Abstract translation: 本发明公开了一种治疗眼科疾病的方法，该方法通过给脊椎动物施用治疗有效量的衍生自α-黑素细胞刺激激素（a-MSH）的肽及其生物功能等同物。 具体地，衍生自α-黑素细胞激素（a-MSH）的肽包括作为MEHFRWG（SEQ ID NO.4）的SYSMEHFRWGKPV（SEQ ID NO：4），a-MSH（4-10）的a-MSH（1-13） SEQ ID NO.2），HFRWGKPV（SEQ ID NO：3）的a-MSH（6-13），KPV（SEQ ID NO：1）的a-MSH（11-13） KPV二聚体（SEQ ID NO：5）。 眼睛病症可能是诸如“电脑眼睛”或眼睛的急性或慢性感染等恶性肿瘤的结果。 感染性生物体可以由包括细菌，真菌或病毒的微生物引起。 脊椎动物包括一只鸟和一只哺乳动物。 肽的解热，抗炎，抗细菌，抗真菌和抗病毒性质，因此可以在妊娠之前的眼科症状开始时施用，导致以下之后确定该病症。

公开(公告)号：WO2004004551A2

公开(公告)日：2004-01-15

申请号：PCT/US2003/021819

申请日：2003-07-10

Applicant: ZENGEN, INC. ,  GATTI, Stefano ,  LIPTON, James, M. ,  CATANIA, Anna, P.

Inventor： GATTI, Stefano ,  LIPTON, James, M. ,  CATANIA, Anna, P.

IPC: A61B

CPC classification number: A61K38/34 ,  A61K2300/00

Abstract: A composition and method for controlling host response to organ and/or tissue transplantation and grafting. Alpha-Melanocyte Stimulating Hormone protects organ and tissue transplantation by controlling factors within the donor, host and of the organ or tissue to be transplanted. Treatment with a-MSH and/or its derivatives can affect warm and cold ischemia times and thus promotes organ viability. Treatment of the donor, host and of the organ or tissue to be transplanted with an appropriate dosage of a-MSH and/or its derivatives limits biochemical pathways that would normally work to reject an organ and/or tissue transplantation. α-MSHaugments successful graft transplantation whether it be allograft or xenograft.

Abstract translation: 用于控制宿主对器官和/或组织移植和移植的反应的组合物和方法。 α-黑素细胞刺激激素通过控制供体，宿主和被移植的器官或组织中的因子来保护器官和组织移植。 用a-MSH和/或其衍生物治疗可以影响冷热缺血时间，从而促进器官活力。 用适当剂量的a-MSH和/或其衍生物处理供体，宿主和要移植的器官或组织，限制通常用于排除器官和/或组织移植的生物化学途径。 α-MSHaugments成功的移植移植，无论是同种异体移植还是异种移植。

公开(公告)号：WO2004004547A3

公开(公告)日：2004-01-15

申请号：PCT/US2003/021236

申请日：2003-07-02

Applicant: MATLOCK, David, L.

Inventor： MATLOCK, David, L.

IPC: A61K31/575

Abstract: Disclosed is a method of colpoplasty wherein the colpoplasty is directed to augmentation, either temporaryof permanent, of the Grafenberg Spot area. The invention disclosed is beneficial in the treatment of femalesexual disorders and is beneficial for women with normal sexual response and esthesia. Also disclosed arekits for performing permanent colpoplastic augmentation of the Grafenberg area. One preferred embodimentof a temporary colpoplasty uses injectable collagen obtained from a tissue bank. One preferred embodimentof a permanent colpoplasty uses implantable ePTFE.

公开(公告)号：WO2003041568A3

公开(公告)日：2003-05-22

申请号：PCT/US2002/036837

申请日：2002-11-15

Applicant: UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY ,  HEWITT, Charles, W. ,  STRANDE, Louise ,  SCHUSTER, Kevin

Inventor： HEWITT, Charles, W. ,  STRANDE, Louise ,  SCHUSTER, Kevin

IPC: A61F2/00

Abstract: The primary aspect of the present invention it directed to a three-dimensional matrix, a living tissue equivalent, a tissue microarray, methods of making thereof, and methods of using thereof. In one embodiment of the invention, the three-dimensional matrix comprises fibroblasts and a fibrin matrix. In a preferred embodiment, the three-dimensional matrix comprises blood plasma, thrombin and fibroblasts. The three-dimensional matrix in accordance with this invention may be used to construct living tissue equivalents, including but not limited to skin, blood vessel, bone, tendon, ligaments, and organ equivalents, among many others. Furthermore, the living tissue equivalents may be used to test the effect of various agents and to study the mechanism of disease and the efficacy of various treatment protocols.

公开(公告)号：WO2003035890A3

公开(公告)日：2003-05-01

申请号：PCT/US2002/026491

申请日：2002-08-20

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  MCKINNON, Randall, D.

Inventor： MCKINNON, Randall, D.

IPC: C12N15/11

Abstract: Nucleic acid sequences that identify a gene product associated with Glioblastoma Multiforme are disclosed. Nucleic acid probes for mRNA transcripts whose expression is associated with glioblast transformation and methods for using these probes in identifying and treating patients at risk for progression into a malignant phenotype are also disclosed.

公开(公告)号：WO2003035890A2

公开(公告)日：2003-05-01

申请号：PCT/US2002/026491

申请日：2002-08-20

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  MCKINNON, Randall, D.

Inventor： MCKINNON, Randall, D.

IPC: C12Q

CPC classification number: C12Q1/6886 ,  C12Q2600/158

Abstract: Nucleic acid sequences that identify a gene product associated with Glioblastoma Multiforme are disclosed. Nucleic acid probes for mRNA transcripts whose expression is associated with glioblast transformation and methods for using these probes in identifying and treating patients at risk for progression into a malignant phenotype are also disclosed.

Abstract translation: 公开了鉴定与多形性成胶质细胞瘤相关的基因产物的核酸序列。 还公开了其表达与成胶质细胞转化相关的mRNA转录物的核酸探针和使用这些探针鉴定和治疗患有进展为恶性表型风险的患者的方法。

公开(公告)号：WO2003034996A3

公开(公告)日：2003-05-01

申请号：PCT/US2002/033875

申请日：2002-10-22

Applicant: AMGEN, INC. ,  DEPAOLI, Alex, M. ,  ORAL, Elif, Arioglu ,  TAYLOR, Simeon, I. ,  GARG, Abhimanyu

Inventor： DEPAOLI, Alex, M. ,  ORAL, Elif, Arioglu ,  TAYLOR, Simeon, I. ,  GARG, Abhimanyu

IPC: G01N33/53

Abstract: Leptin, leptin analogs, and leptin derivatives are used to treat patients with lipodystrophy. Leptin is effective against lipodystrophy conditions for both genetic and acquired forms of the disease. A therapeutically effective amount of leptin can be administered in a variety of ways, including in a vector comprising nucleic acid sequences encoding leptin. Methods of the present invention contemplate administration of leptin, leptin analogs, and leptin derivatives to patients having approximately 4 ng/ml or less before treatment.

公开(公告)号：WO2003034996A2

公开(公告)日：2003-05-01

申请号：PCT/US2002/033875

申请日：2002-10-22

Applicant: AMGEN, INC. ,  DEPAOLI, Alex, M. ,  ORAL, Elif, Arioglu ,  TAYLOR, Simeon, I. ,  GARG, Abhimanyu

Inventor： DEPAOLI, Alex, M. ,  ORAL, Elif, Arioglu ,  TAYLOR, Simeon, I. ,  GARG, Abhimanyu

IPC: A61K

CPC classification number: A61K38/2264 ,  A61K31/155 ,  A61K31/426 ,  A61K45/06 ,  G01N33/68 ,  G01N33/74 ,  A61K2300/00

Abstract: Leptin, leptin analogs, and leptin derivatives are used to treat patients with lipodystrophy. Leptin is effective against lipodystrophy conditions for both genetic and acquired forms of the disease. A therapeutically effective amount of leptin can be administered in a variety of ways, including in a vector comprising nucleic acid sequences encoding leptin. Methods of the present invention contemplate administration of leptin, leptin analogs, and leptin derivatives to patients having approximately 4 ng/ml or less before treatment.

Abstract translation: 瘦素，瘦素类似物和瘦素衍生物用于治疗脂肪代谢障碍的患者。 瘦素对抗疾病的遗传和获得形式的脂肪营养不良疾病是有效的。 瘦素的治疗有效量可以多种方式施用，包括在包含编码瘦素的核酸序列的载体中。 本发明的方法考虑在治疗前向瘦素，瘦素类似物和瘦素衍生物给予约4ng / ml或更少的患者。

公开(公告)号：WO2003007890A3

公开(公告)日：2003-01-30

申请号：PCT/US2002/023426

申请日：2002-07-22

Applicant: UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY ,  UNIVERSITY OF IOWA RESEARCH FOUNDATION ,  DAS, Kiron, M. ,  LIN, Jim, Chung-Ching

Inventor： DAS, Kiron, M. ,  LIN, Jim, Chung-Ching

IPC: C07K14/00

Abstract: A novel isoform of tropomyosin is disclosed. The isoform is closely related to epithelial human tropomyosin (hTM) and more particularly to hTM5 except the last coding exon. The novel isoform is call TC22. Northern blot analysis with TC22-specific probe revealed that normal culture cell lines and normal epithelial tissues expressed very little, if at all, TC22 message, whereas their transformed counterparts and tumor tissues including dysfunction of the alimentary canal, significantly increased the expression of TC22. Assays directed at determining the level of TC22 are useful in diagnostics and therapeutics of dysfunction of the alimentary canal. Specific antibodies and mimics of TC22 are also disclosed for use in diagnostics and therapeutics of dysfunction of the alimentary canal.

公开(公告)号：WO2022232846A1

公开(公告)日：2022-11-03

申请号：PCT/US2022/072027

申请日：2022-04-29

Applicant: LIGANDAL, INC.

Inventor： WATSON, Andre

IPC: B01J16/00 ,  B01J19/00 ,  B01J19/18

Abstract: Methods and compositions for manufacturing large-scale quantities of conjugatable peptides/peptoids/polymers/nucleic acids and conjugatable proteins, as well as hybrid materials consisting of synthetic and unnatural amino acids, glycopeptides, proteoglycans, and other molecular modifications are disclosed, for a variety of purposes including rapid antidote and vaccine applications in biodefense, therapeutics, diagnostics, theranostics, thin films, multilayered assemblies, biofilms, sensors, drug delivery vehicles, gene delivery vehicles, gene editing vehicles, staged release compounds, and the like.