公开(公告)号：WO2005025503A2

公开(公告)日：2005-03-24

申请号：PCT/US2004/029322

申请日：2004-09-08

Applicant: ZENGEN, INC. ,  CATANIA, Anna, P. ,  LIPTON, James, M.

Inventor： CATANIA, Anna, P. ,  LIPTON, James, M.

IPC: A61K

CPC classification number: A61K38/07 ,  A61K9/0034 ,  A61K9/06 ,  A61K38/06 ,  A61K38/34 ,  A61K47/10 ,  A61K47/32

Abstract: The present invention is directed to a composition and method for treating uro-genital conditions. One embodiment disclosed is a pharmaceutical composition for use in the treatment of uro-genital conditions wherein said composition comprises a KPV dimer, a first preservative agent, a solvent, an alkalizer, an acrylic acid-based polymer, a second preservative agent and a gelatinizing agent. Another embodiment of the invention is disclosed wherein the composition comprises CKPV (SEQ ID NO: 5) dimer, API, Carbopol(r), NF, propylparaben, NF; methylparaben, NF; propylene glycol, USP; edetic acid (EDTA), USP; 2 M sodium hydroxide solution (NaOH); and sterile water for injection, USP. Also disclosed are methods and indications for use of the disclosed composition.

Abstract translation: 本发明涉及用于治疗泌尿生殖道病症的组合物和方法。 所公开的一个实施方案是用于治疗泌尿生殖道病症的药物组合物，其中所述组合物包含KPV二聚体，第一防腐剂，溶剂，碱化剂，丙烯酸类聚合物，第二防腐剂和凝胶化 剂。 公开了本发明的另一个实施方案，其中组合物包含CKPV（SEQ ID NO：5）二聚体，API，Carbopol（r），NF，对羟基苯甲酸丙酯，NF; 对羟基苯甲酸甲酯，NF; 丙二醇，USP; 乙二胺四乙酸（EDTA），USP; 2M氢氧化钠溶液（NaOH）; 和无菌注射用水。 还公开了使用所公开的组合物的方法和指示。

公开(公告)号：WO2004046165A2

公开(公告)日：2004-06-03

申请号：PCT/US2003/036184

申请日：2003-11-14

Applicant: ZENGEN, INC. ,  LIPTON, James, M.

Inventor： LIPTON, James, M.

IPC: C07K

CPC classification number: A61K38/34 ,  A61K9/0048

Abstract: The present invention discloses a method of treating ophthalmic conditions by administering to a vertebrateinflicted with the condition a therapeutically effective amount of a peptide which is derived from alpha-melanocyte-stimulating hormone (a-MSH) and biologically functional equivalents thereof. Specifically,the peptides derived from alpha-melanocyte-stimulating hormone (a-MSH) include a-MSH (1-13) which is SYSMEHFRWGKPV (SEQ. ID NO. 4), a-MSH (4-10) which is MEHFRWG (SEQ. ID NO. 2), a-MSH (6-13)which is HFRWGKPV (SEQ. ID NO. 3), a-MSH (11-13) which is KPV (SEQ. ID NO. 1), and a KPV dimer(SEQ. ID NO. 5). The ophthalmic condition can be the result of an on going insult such as "Computer Eyes"or an acute or chronic infection of the eyes. The infective organism can be caused by a microorganism,which includes a bacteria, a fungi or a virus. The vertebrate includes a bird and a mammal. The peptidehas antipyretic, anti-inflammatory, anti-bacterial, antifungal, and antiviral properties and therefore can be administered at the onset of the ophthalmic condition before the insult causing the condition is determinedas well as thereafter.

Abstract translation: 本发明公开了一种治疗眼科疾病的方法，该方法通过给脊椎动物施用治疗有效量的衍生自α-黑素细胞刺激激素（a-MSH）的肽及其生物功能等同物。 具体地，衍生自α-黑素细胞激素（a-MSH）的肽包括作为MEHFRWG（SEQ ID NO.4）的SYSMEHFRWGKPV（SEQ ID NO：4），a-MSH（4-10）的a-MSH（1-13） SEQ ID NO.2），HFRWGKPV（SEQ ID NO：3）的a-MSH（6-13），KPV（SEQ ID NO：1）的a-MSH（11-13） KPV二聚体（SEQ ID NO：5）。 眼睛病症可能是诸如“电脑眼睛”或眼睛的急性或慢性感染等恶性肿瘤的结果。 感染性生物体可以由包括细菌，真菌或病毒的微生物引起。 脊椎动物包括一只鸟和一只哺乳动物。 肽的解热，抗炎，抗细菌，抗真菌和抗病毒性质，因此可以在妊娠之前的眼科症状开始时施用，导致以下之后确定该病症。

公开(公告)号：WO2004004551A2

公开(公告)日：2004-01-15

申请号：PCT/US2003/021819

申请日：2003-07-10

Applicant: ZENGEN, INC. ,  GATTI, Stefano ,  LIPTON, James, M. ,  CATANIA, Anna, P.

Inventor： GATTI, Stefano ,  LIPTON, James, M. ,  CATANIA, Anna, P.

IPC: A61B

CPC classification number: A61K38/34 ,  A61K2300/00

Abstract: A composition and method for controlling host response to organ and/or tissue transplantation and grafting. Alpha-Melanocyte Stimulating Hormone protects organ and tissue transplantation by controlling factors within the donor, host and of the organ or tissue to be transplanted. Treatment with a-MSH and/or its derivatives can affect warm and cold ischemia times and thus promotes organ viability. Treatment of the donor, host and of the organ or tissue to be transplanted with an appropriate dosage of a-MSH and/or its derivatives limits biochemical pathways that would normally work to reject an organ and/or tissue transplantation. α-MSHaugments successful graft transplantation whether it be allograft or xenograft.

Abstract translation: 用于控制宿主对器官和/或组织移植和移植的反应的组合物和方法。 α-黑素细胞刺激激素通过控制供体，宿主和被移植的器官或组织中的因子来保护器官和组织移植。 用a-MSH和/或其衍生物治疗可以影响冷热缺血时间，从而促进器官活力。 用适当剂量的a-MSH和/或其衍生物处理供体，宿主和要移植的器官或组织，限制通常用于排除器官和/或组织移植的生物化学途径。 α-MSHaugments成功的移植移植，无论是同种异体移植还是异种移植。

公开(公告)号：WO2004046166A2

公开(公告)日：2004-06-03

申请号：PCT/US2003/036396

申请日：2003-11-14

Applicant: ZENGEN, INC. ,  LIPTON, James, M.

Inventor： LIPTON, James, M.

IPC: C07K

CPC classification number: C07K14/68 ,  A61K38/00

Abstract: Novel peptides with antimicrobial activity are disclosed. The novel peptides are octomeric peptides modifiedfrom a-MSH. The modified a-MSH antimicrobial peptides disclosed herein may have enhanced activity against microbes over a-MSH due to modifications in peptide sequence and chirality of amino acids. Due an identified mechanism of action for antimicrobial activity in which cAMP accumulates in the microbial cell, it may be that microbes will not generate resistance to these modified a-MSH antimicrobial peptides.

Abstract translation: 公开了具有抗微生物活性的新型肽。 新型肽是由a-MSH修饰的八聚体肽。 由于肽序列的修饰和氨基酸的手性，本文公开的经修饰的a-MSH抗微生物肽可能具有比a-MSH更高的抗微生物活性。 由于cAMP在微生物细胞中积聚的抗菌活性的鉴定机制，微生物不会对这些修饰的a-MSH抗微生物肽产生抗性。

公开(公告)号：WO2002069884A2

公开(公告)日：2002-09-12

申请号：PCT/US2001/051090

申请日：2001-10-29

Applicant: ZENGEN, INC. ,  LIPTON, James, M.

Inventor： LIPTON, James, M.

IPC: A61K

CPC classification number: C07K14/685 ,  A61K8/64 ,  A61K31/167 ,  A61K36/61 ,  A61K36/886 ,  A61K38/02 ,  A61Q19/004 ,  C07K5/0815 ,  A61K2300/00

Abstract: The present invention is directed to a treatment for sunburn and a method for preventing sunburn. One aspect of this invention involves a sunburn treatment comprising one or more polypeptides with an amino acid sequence including KPV (SEQ. ID. NO. 1), MEHFRWG (SEQ. ID. NO. 2), HFRWGKPV (SEQ. ID. NO. 3), or SYSMEHFRWGKPV (SEQ. ID. NO. 4) for the treatment of the cutaneous inflammation caused by exposure to ultraviolet radiation. The polypeptides are at a level to effectively treat the cutaneous inflammation and are carried by a carrier. The one or more polypeptides can also be a dimer formed from any of the amino acid sequence above. In one preferred embodiment of the invention, the one or more polepeptides are used to prevent sunburn. In another preferred embodiment, the one or more polepeptides are dissolved in a carrier. In another preferred embodiment, the carrier includes aloe vera and lidocaine hydrochloride. In another preferred embodiment of the invention, the one or more polypeptides are dissolved in a liquid that is associated with an absorbent material for application to sunburned skin.

Abstract translation: 本发明涉及一种晒伤治疗方法及防晒方法。 本发明的一个方面涉及包含一种或多种具有包括KPV（SEQ ID NO：1），MEHFRWG（SEQ ID NO：2），HFRWGKPV（SEQ ID NO： 3）或用于治疗由紫外线辐射引起的皮肤炎症的SYSMEHFRWGKPV（SEQ.ID.NO.4）。 多肽处于有效治疗皮肤炎症的水平，并由载体携带。 一种或多种多肽也可以是由上述任何氨基酸序列形成的二聚体。 在本发明的一个优选实施方案中，使用一种或多种极肽来防止晒伤。 在另一个优选的实施方案中，一种或多种极肽溶解在载体中。 在另一个优选的实施方案中，载体包括芦荟和盐酸利多卡因。 在本发明的另一个优选实施方案中，一种或多种多肽溶解在与用于晒伤皮肤的吸收材料相关联的液体中。

公开(公告)号：WO2004104019A2

公开(公告)日：2004-12-02

申请号：PCT/US2004/015208

申请日：2004-05-14

Applicant: ZENGEN, INC. ,  LIPTON, James, M.

Inventor： LIPTON, James, M.

IPC: C07K

CPC classification number: A61K38/04 ,  A61K9/0019 ,  A61K9/06 ,  A61L26/0028 ,  A61L26/008

Abstract: A composition and method of treatment are disclosed in which anti-microbial and anti-inflammatory peptides are used for hemodialysis and peritoneal dialysis in dialysate and gel. An unexpected result of the invention has also been disclosed wherein the anti-microbial and anti-inflammatory peptides may be used in peritoneal dialysis to increase diuresis. Other embodiments of the invention include use of the anti-microbial and anti-inflammatory peptides in locking solutions used for catheters and other vascular access tubing or peritoneal access tubing.

Abstract translation: 公开了一种治疗的组合物和方法，其中抗微生物和抗炎肽用于透析液和凝胶中的血液透析和腹膜透析。 还公开了本发明的意想不到的结果，其中抗微生物和抗炎肽可用于腹膜透析以增加利尿。 本发明的其它实施方案包括在用于导管和其它血管通路管或腹膜通路管的锁定溶液中使用抗微生物剂和抗炎肽。

公开(公告)号：WO2003051390A1

公开(公告)日：2003-06-26

申请号：PCT/US2002/040313

申请日：2002-12-17

Applicant: ZENGEN, INC. ,  LIPTON, James, M. ,  CATANIA, Anna, P.

Inventor： LIPTON, James, M. ,  CATANIA, Anna, P.

IPC: A61K38/34

CPC classification number: A61K9/0017 ,  A61K8/64 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/2018 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/2063 ,  A61K38/06 ,  A61K38/08 ,  A61K38/10 ,  A61K38/34 ,  A61K47/12 ,  A61K47/20 ,  A61K2800/75 ,  A61Q17/00

Abstract: The present invention is directed to a treatment for animal pruritus. One aspect of this invention involves a treatment for animal pruritus comprising one or more polypeptides with an amino acid sequence including KPV (SEQ ID NO: 1), VKP-Ac CC-Ac-KPV (SEQ ID NO: 5), MEHFRWG (SEQ ID NO: 2), HFRWGKPV (SEQ ID NO: 3) or SYSMEHFRWGKPV (SEQ ID NO: 4) for animal pruritus caused by exposure to any number of agents or causes. The polypeptides are at a level to effectively treat the animal pruritus and are combined with a shampoo. Other combinations include the polypeptides at a level to effectively treat animal pruritus combined with a shampoo and an antibiotic, antifungal and/or and anti-inflammatory. The one or more polypeptides can also be a dimer formed from any of the amino acid sequence above.

Abstract translation: 本发明涉及动物瘙痒症的治疗。 本发明的一个方面涉及包含一种或多种具有包括KPV（SEQ ID NO：1），VKP-Ac CC-Ac-KPV（SEQ ID NO：5），MEHFRWG（SEQ ID NO：1） ID NO：2），HFRWGKPV（SEQ ID NO：3）或SYSMEHFRWGKPV（SEQ ID NO：4），用于由暴露于任何数量的试剂或原因引起的动物瘙痒。 多肽处于有效治疗动物瘙痒的水平，并与洗发剂组合。 其他组合包括能够有效治疗动物瘙痒与洗发剂和抗生素，抗真菌剂和/或抗炎症组合的水平的多肽。 一种或多种多肽也可以是由上述任何氨基酸序列形成的二聚体。

公开(公告)号：WO2002069884A3

公开(公告)日：2002-09-12

申请号：PCT/US2001/051090

申请日：2001-10-29

Applicant: ZENGEN, INC. ,  LIPTON, James, M.

Inventor： LIPTON, James, M.

IPC: C07K17/00

Abstract: The present invention is directed to a treatment for sunburn and a method for preventing sunburn. One aspect of this invention involves a sunburn treatment comprising one or more polypeptides with an amino acid sequence including KPV (SEQ. ID. NO. 1), MEHFRWG (SEQ. ID. NO. 2), HFRWGKPV (SEQ. ID. NO. 3), or SYSMEHFRWGKPV (SEQ. ID. NO. 4) for the treatment of the cutaneous inflammation caused by exposure to ultraviolet radiation. The polypeptides are at a level to effectively treat the cutaneous inflammation and are carried by a carrier. The one or more polypeptides can also be a dimer formed from any of the amino acid sequence above. In one preferred embodiment of the invention, the one or more polepeptides are used to prevent sunburn. In another preferred embodiment, the one or more polepeptides are dissolved in a carrier. In another preferred embodiment, the carrier includes aloe vera and lidocaine hydrochloride. In another preferred embodiment of the invention, the one or more polypeptides are dissolved in a liquid that is associated with an absorbent material for application to sunburned skin.

公开(公告)号：WO2002064046A3

公开(公告)日：2002-08-22

申请号：PCT/US2002/003039

申请日：2002-01-22

Applicant: ZENGEN, INC. ,  LIPTON, James, M.

Inventor： LIPTON, James, M.

IPC: A61K38/00

Abstract: The broadest aspect of the invention is a composition and method of treatment of fungal pathologies of the oral cavity or fungal growth on the surface of dentures. A preferred embodiment of the invention is a pharmacologically effective amount of a peptide selected from the group of peptides with a C-terminal sequence consisting of KPV, HFRWGKPV, and SYSMEHFRWGKPV in combination with a therapeutically effective amount of a fungicide selected from the group consisting of: itraconazole, econazole, ketoconazole, miconazole and fluconazole. Another embodiment of the invention is a method for treating fungal pathologies of the of oral cavity and dentures by application of a pharmacologically effective amount of a peptide selected from the group of peptides with a C-terminal sequence consisting of KPV, HFRWGKPV, and SYSMEHFRWGKPV in combination with a therapeutically effective amount of a fungicide selected from the group consisting of: itraconazole, econazole, ketoconazole, miconazole and fluconazole. In yet another embodiment of the invention these peptides are used in combination with a therapeutically effective amount of gram positive and/or gram negative antibiotics.

公开(公告)号：WO2002080858A2

公开(公告)日：2002-10-17

申请号：PCT/US2002/012771

申请日：2002-04-06

Applicant: LIPTON, James, M. ,  CATANIA, Anna, P.

Inventor： LIPTON, James, M. ,  CATANIA, Anna, P.

IPC: A61K

CPC classification number: C07K14/685 ,  A61K38/34 ,  A61K45/06 ,  C07K5/0815 ,  C07K5/1008 ,  A61K2300/00

Abstract: The present invention is directed to a prevention and treatment for dermatological disorders. One aspect of this invention involves a dermatological treatment comprising one or more polypeptides with an amino acid sequence including KPV (SEQ. ID.NO. 1), MEHFRWGKPV (SEQ. ID. NO. 2), HFRWGKPV (SEQ. ID. NO. 3), OS SYSMEHFRWGKPV (SEQ. ID. NO. 4) for the treatment and prevention of dermatological disorders. The polypeptides are at a level to effectively treat the cutaneous inflammation and are carried by a carrier. The one or more polypeptides can also be a dimer formed from any of the amino acid sequences above.

Abstract translation: 本发明涉及皮肤病学的预防和治疗。 本发明的一个方面涉及皮肤病学处理，其包含一种或多种具有包括KPV（SEQ ID NO：1），MEHFRWGKPV（SEQ ID NO：2），HFRWGKPV（SEQ ID NO： 3），用于治疗和预防皮肤病的OS SYSMEHFRWGKPV（SEQ.ID.NO.4）。 多肽处于有效治疗皮肤炎症的水平，并由载体携带。 一种或多种多肽也可以是由上述任何氨基酸序列形成的二聚体。