公开(公告)号：WO2011031665A3

公开(公告)日：2011-06-03

申请号：PCT/US2010047970

申请日：2010-09-07

Applicant: PURDUE RESEARCH FOUNDATION ,  DH TECHNOLOGIES DEV PTE LTD ,  HASSELL KERRY MARIE ,  MCLUCKEY SCOTT A ,  LEBLANC YVES

Inventor： HASSELL KERRY MARIE ,  MCLUCKEY SCOTT A ,  LEBLANC YVES

IPC: G01N30/72 ,  G01N27/62 ,  G01N30/12

CPC classification number: H01J49/0072 ,  H01J49/004 ,  H01J49/165 ,  Y10T436/24

Abstract: An apparatus and method for a sample using a mass spectrometer is described, including, generating ions of a first polarity from an analyte using electrospray ionization; generating ions of a second polarity from a reagent; injecting the ions of the first polarity and ions of the second polarity in sequence into a chamber of the mass spectrometer such that the ions of the first polarity and the ions of the second polarity interact in the chamber to form analyte ions having the second polarity; and, analyzing the mass spectrum of the analyte ions of the second polarity. A reagent such as a polyamidomine is selected to preferentially yield analyte ions of the second polarity having a desired mass-to-charge ratio.

Abstract translation: 描述了使用质谱仪的样品的设备和方法，包括：使用电喷雾电离从分析物产生第一极性的离子; 从试剂产生第二极性的离子; 将第一极性的离子和第二极性的离子顺序地注入到质谱仪的腔室中，使得第一极性的离子和第二极性的离子在腔室中相互作用以形成具有第二极性的分析物离子; 以及分析第二极性的分析物离子的质谱。 选择诸如聚酰胺咪唑的试剂以优先产生具有期望的质荷比的第二极性的分析物离子。