公开(公告)号：WO2014057345A2

公开(公告)日：2014-04-17

申请号：PCT/IB2013002293

申请日：2013-10-11

Applicant: DH TECHNOLOGIES DEV PTE LTD

Inventor： BABA TAKASHI

IPC: H01J37/317

CPC classification number: H01J49/062 ,  H01J49/0031 ,  H01J49/067 ,  H01J49/22

Abstract: An ion guide is provided having an enclosure extending longitudinally around a central axis from a proximal inlet end to a distal outlet end. The proximal inlet end receives a plurality of ions entrained in a gas flow through an inlet orifice. A deflection plate is disposed within the enclosure between the proximal and distal ends and deflects at least a portion of the gas flow away from a central direction of the gas flow. A plurality of electrically conductive, elongate elements extend from the proximal end to the distal end within the enclosure and generate an electric field via a combination of RF and DC electric potentials. The electric field deflects the entrained ions away from the central direction of the gas flow proximal to the deflection plate and confines the deflected ions in proximity of the elongated elements as the ions travel downstream.

Abstract translation: 提供离子引导件，其具有围绕中心轴线从近端入口端部至远端出口端部纵向延伸的外壳。 近端入口端容纳夹带在通过入口孔的气流中的多个离子。 偏转板在近端和远端之间的外壳内设置，并使气流的至少一部分偏离气流的中心方向。 多个导电细长元件从外壳内的近端延伸到远端，并通过RF和DC电势的组合产生电场。 电场使夹带的离子偏离靠近偏转板的气流的中心方向，并且当离子向下游行进时，将偏转的离子限制在细长元件附近。

公开(公告)号：WO2009149546A8

公开(公告)日：2011-02-17

申请号：PCT/CA2009000805

申请日：2009-06-08

Applicant: DH TECHNOLOGIES DEV PTE LTD ,  GUNA MIRCEA ,  LONDRY FRANK

Inventor： GUNA MIRCEA ,  LONDRY FRANK

IPC: H01J49/42

CPC classification number: H01J49/4265 ,  H01J49/0031 ,  H01J49/004

Abstract: A method for operating tandem ion traps is provided, involving a) accumulating ions in the first ion trap at a first time; b) transmitting a first plurality of ions out of the first ion trap and into the second ion trap at a second time, the first plurality of ions having masses within a first mass range; c) retaining a second plurality of ions in the first ion trap at the second time, the second plurality of ions having masses within a second mass range different from the first mass range; d) transmitting the first plurality of ions out of the second ion trap at a third time; and, e) transmitting the second plurality of ions out of the first ion trap and into the second ion trap at the third time.

Abstract translation: 提供了一种用于操作串联离子阱的方法，包括：a）在第一时间将第一离子阱中的离子累积; b）在第二时间将第一多个离子从第一离子阱中传输到第二离子阱中，第一多个离子具有在第一质量范围内的质量; c）在第二时间将第二多个离子保留在第一离子阱中，第二多个离子具有在与第一质量范围不同的第二质量范围内的质量; d）第三次将第一多个离子从第二离子阱中传出; 以及e）第三次将第二多个离子从第一离子阱中传出并进入第二离子阱。

公开(公告)号：WO2013093582A3

公开(公告)日：2013-08-22

申请号：PCT/IB2012002523

申请日：2012-11-28

Applicant: DH TECHNOLOGIES DEV PTE LTD

Inventor： CAMPBELL JOHN L ,  HAGER JAMES

IPC: H01J49/42 ,  G01N27/62 ,  H01J49/10

CPC classification number: H01J49/0031 ,  H01J49/42 ,  H01J49/4215

Abstract: In some embodiments, a quantitative analysis of at least one ion signal associated with a sample, which is detected by a mass spectrometer having at least two tandem quadrupole instruments, is employed to select one of the following operational modes for further mass analysis of the sample: (a) utilizing both quadrupole instruments as mass resolving filters, and (b) utilizing one quadrupole instrument as a mass resolving filter and utilizing the other as a linear ion trap. In some embodiments, the quantitative analysis of the ion signal comprises comparing the ion signal intensity with a predefined threshold.

Abstract translation: 在一些实施方案中，采用与具有至少两个串联四极杆仪器的质谱仪检测到的与样品相关联的至少一个离子信号的定量分析来选择以下操作模式之一用于样品的进一步质量分析 ：（a）利用四极仪器作为质量分辨率滤波器，（b）利用一个四极仪器作为质量分辨率滤波器，并利用另一个作为线性离子阱。 在一些实施例中，离子信号的定量分析包括将离子信号强度与预定阈值进行比较。

公开(公告)号：WO2012164378A2

公开(公告)日：2012-12-06

申请号：PCT/IB2012001054

申请日：2012-05-30

Applicant: DH TECHNOLOGIES DEV PTE LTD ,  TATE STEPHEN A ,  BLOOMFIELD NIC G

Inventor： TATE STEPHEN A ,  BLOOMFIELD NIC G

IPC: H01J49/00

CPC classification number: H01J49/06 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/429

Abstract: Systems and methods are used to band-pass filter ions from a mass range. A full spectrum is received for a full scan of a mass range using a tandem mass spectrometer. A mass selection window of the full spectrum is selected and a set of tuning parameter values is selected. The tandem mass spectrometer is instructed to perform a scan of the mass selection window using the set of tuning parameter values. A spectrum is received for the scan from the tandem mass spectrometer. A band-pass filtered spectrum is created for the mass range that includes values from the spectrum for the mass selection window of the mass range. Systems and methods are also used to band-pass filter ions from two or more mass selection windows across the mass range and to filter out ions from a mass selection window between two band-pass mass selection windows.

Abstract translation: 系统和方法用于使质量范围内的过滤离子带通。 使用串联质谱仪可以接收全质谱进行质量范围的全扫描。 选择全频谱的质量选择窗口，并选择一组调谐参数值。 指示串联质谱仪使用一组调谐参数值执行质量选择窗口的扫描。 接收从串联质谱仪扫描的光谱。 为包括质量范围的质量选择窗口的光谱值的质量范围创建带通滤波光谱。 系统和方法也用于跨越质量范围的两个或多个质量选择窗口带通滤波器离子，并从两个带通质量选择窗口之间的质量选择窗口滤除离子。

公开(公告)号：WO2011073794A3

公开(公告)日：2011-11-03

申请号：PCT/IB2010003304

申请日：2010-12-17

Applicant: DH TECHNOLOGIES DEV PTE LTD ,  HAGER JAMES W ,  LE BLANC YVES

Inventor： HAGER JAMES W ,  LE BLANC YVES

IPC: H01J49/00

CPC classification number: H01J49/005 ,  H01J49/0031

Abstract: A method for obtaining fragment ions having product ion spectrum with a mixture of high, medium and lower energy product ions. The method includes (a) providing a selected RF field to an ion optical element upstream of an ion containment field; (b) transmitting ions through the ion optical element and into the ion containment field such that the selected RF field determines, at least in part, a selected kinetic energy profile of the ions within the ion containment field, wherein the selected kinetic energy profile is selected to fragment the ions to concurrently provide a plurality of groups of product ions; and (c) detecting each group of product ions in the plurality of groups of product ions.

Abstract translation: 一种用高，中和低能量产物离子的混合物获得具有产物离子谱的碎片离子的方法。 该方法包括：（a）向离子遏制场上游的离子光学元件提供选定的RF场; （b）将离子传输通过离子光学元件并进入离子封闭场，使得所选择的RF场至少部分地确定离子封闭场内离子的选定动能轮廓，其中所选择的动能轮廓为 选择以碎裂离子以同时提供多组产物离子; 和（c）检测多组产品离子中的每组产品离子。

公开(公告)号：WO2011095863A3

公开(公告)日：2011-10-27

申请号：PCT/IB2011000152

申请日：2011-01-31

Applicant: DH TECHNOLOGIES DEV PTE LTD ,  LOBODA ALEXANDRE

Inventor： LOBODA ALEXANDRE

IPC: H01J49/40 ,  H01J49/00

CPC classification number: H01J49/025 ,  G01T1/17 ,  H01J49/0027 ,  H01J49/40

Abstract: Dual TDC-ADC detection systems for time of flight mass spectrometry are disclosed herein. Detection systems based upon TDC generally provide higher timing resolution as opposed to detection systems based upon ADC. However, ADC generally provides increased dynamic range over TDC. By combining TDC and ADC into a tandem detector, and adjusting performance parameters of the respective converter types, the dynamic range of the dual TDC-ADC detection can be extended beyond what either detector type could have achieved individually. Composite time of flight mass spectra can be generated by aggregating individual mass spectra acquired from multiple time-of-flight extractions, and selecting the number of time-of-flight extractions to ensure overlap between the ADC and TDC dynamic ranges in the dual TDC-ADC detector system.

Abstract translation: 本文公开了用于飞行时间质谱的双TDC-ADC检测系统。 与基于ADC的检测系统相反，基于TDC的检测系统通常提供更高的定时分辨率。 然而，ADC通常提供比TDC更大的动态范围。 通过将TDC和ADC组合成串联检测器，并调整各种转换器类型的性能参数，双TDC-ADC检测的动态范围可以扩展到单独检测器类型之外。 复合飞行时间质谱可以通过聚合从多次飞行时间提取获得的单个质谱，并选择飞行时间提取次数，以确保双TDC中ADC和TDC动态范围之间的重叠， ADC检测器系统。

公开(公告)号：WO2010141075A8

公开(公告)日：2011-10-27

申请号：PCT/US2010001598

申请日：2010-06-01

Applicant: DH TECHNOLOGIES DEV PTE LTD ,  DEY SUBHAKAR ,  PILLAI SASI ,  WILLIAMSON BRIAN L ,  PURKAYASTHA SUBHASISH ,  WEINSTOCK MICHAL

Inventor： DEY SUBHAKAR ,  PILLAI SASI ,  WILLIAMSON BRIAN L ,  PURKAYASTHA SUBHASISH ,  WEINSTOCK MICHAL

IPC: G01N37/00

CPC classification number: G01N30/72 ,  G01N27/62 ,  G01N33/64 ,  G01N33/743 ,  G01N2030/045 ,  G01N2030/884 ,  H01J49/00 ,  H01J49/0045 ,  H01J49/164 ,  Y10T436/147777 ,  Y10T436/200833

Abstract: Labeling reagents, sets of labeling reagents, and labeling techniques are provided for the relative quantitation, absolute quantitation, or both, of ketone or aldehyde compounds including, but not limited to, analytes comprising steroids or ketosteroids. The analytes can be medical or pharmaceutical compounds in biological samples. Methods for labeling, analyzing, and quantifying ketone or aldehyde compounds are also disclosed as are methods that also use mass spectrometry.

Abstract translation: 提供了标记试剂，一组标记试剂和标记技术用于酮或醛化合物的相对定量，绝对定量或两者，包括但不限于包含类固醇或酮类固醇的分析物。 分析物可以是生物样品中的医药或药物化合物。 还公开了用于标记，分析和定量酮或醛化合物的方法，也是也使用质谱法的方法。

公开(公告)号：WO2013171555A1

公开(公告)日：2013-11-21

申请号：PCT/IB2013000729

申请日：2013-04-19

Applicant: DH TECHNOLOGIES DEV PTE LTD

Inventor： COLLINGS BRUCE ANDREW ,  DIMA MARTIAN ,  IVOSEV GORDANA

IPC: H01J49/26

CPC classification number: H01J49/0027 ,  G01T1/171 ,  H01J49/0009 ,  H01J49/0036 ,  H01J49/025

Abstract: Systems and methods are provided to perform dead time correction. An observed ion count rate is obtained using a non-paralyzable detection system of a mass spectrometer. The detection system includes an ion detector, a comparator/discriminator, a mono-stable circuit and a counter. The non- paralyzable detection system exhibits dead time extension at high count rates. The extension of the dead time occurs because the mono-stable circuit requires a rising edge to trigger and can only be triggered again after the output pulse from the comparator/discriminator has gone low. This allows a second comparator/discriminator pulse arriving just before the end of the dead time started by a first comparator/discriminator pulse to extend the dead time to the trailing edge of the second comparator/discriminator pulse. A true ion count rate is calculated by performing dead time correction of the observed ion count rate.

Abstract translation: 提供系统和方法来执行死区时间校正。 使用质谱仪的非可分离检测系统获得观察到的离子计数率。 检测系统包括离子检测器，比较器/鉴别器，单稳态电路和计数器。 非可分析检测系统以高计数率显示死区时间延长。 由于单稳态电路需要上升沿触发，只能在比较器/鉴位器的输出脉冲变低后再次触发，才会延长死区时间。 这允许在由第一比较器/鉴频器脉冲开始的死区时间结束之前到达第二比较器/鉴频器脉冲，从而将死区时间延长到第二比较器/鉴频器脉冲的后沿。 通过对观察到的离子计数率执行死区时间校正来计算真实的离子计数率。

公开(公告)号：WO2012063108A2

公开(公告)日：2012-05-18

申请号：PCT/IB2011002594

申请日：2011-11-02

Applicant: DH TECHNOLOGIES DEV PTE LTD ,  BONNER RONALD ,  TATE STEPHEN A

Inventor： BONNER RONALD ,  TATE STEPHEN A

IPC: H01J49/00

CPC classification number: H01J49/0045 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/04

Abstract: Systems and methods are used to rapidly screening samples. A fast sample introduction device that is non-chromatographic is instructed to supply each sample of a plurality samples to a tandem mass spectrometer using a processor. The fast sample introduction device can include a flow injection analysis device, an ion mobility analysis device, or a rapid sample cleanup device. The tandem mass spectrometer is instructed to perform fragmentation scans at two or more mass selection windows across a mass range of each sample of the plurality of samples using the processor. The two or more mass selection windows across the mass range can have fixed or variable window widths. The tandem mass spectrometer can be instructed to obtain a mass spectrum of the mass range before instructing the tandem mass spectrometer to perform the fragmentation scans.

Abstract translation: 系统和方法用于快速筛选样品。 指示非色谱的快速样品引入装置使用处理器将多个样品的每个样品提供给串联质谱仪。 快速样品引入装置可以包括流动注射分析装置，离子迁移率分析装置或快速样品清除装置。 指示串联质谱仪在使用处理器的多个采样的质量范围的两个或更多个质量选择窗口上进行碎片扫描。 跨质量范围的两个或多个质量选择窗口可以具有固定或可变窗口宽度。 在指示串联质谱仪进行碎片扫描之前，可以指示串联质谱仪获得质量范围的质谱。

公开(公告)号：WO2011140492A3

公开(公告)日：2012-01-26

申请号：PCT/US2011035604

申请日：2011-05-06

Applicant: UT BATTELLE LLC ,  DH TECHNOLOGIES DEV PTE LTD ,  VAN BERKEL GARY J ,  COVEY THOMAS

Inventor： VAN BERKEL GARY J ,  COVEY THOMAS

IPC: H01J49/00

CPC classification number: G01N1/4055 ,  B01L3/502715 ,  G01N2001/028 ,  H01J49/00

Abstract: A system and method is disclosed for extracting a sample from a sample surface. A sample is provided and a sample surface receives the sample which is deposited on the sample surface. A hydrophobic material is applied to the sample surface, and one or more devices are configured to dispense a liquid on the sample, the liquid dissolving the sample to form a dissolved sample material, and the one or more devices are configured to extract the dissolved sample material from the sample surface.

Abstract translation: 公开了从样品表面提取样品的系统和方法。 提供样品并且样品表面接收沉积在样品表面上的样品。 将疏水性材料施加到样品表面，并且一个或多个装置构造成分配样品上的液体，溶解样品的液体以形成溶解的样品材料，并且一个或多个装置被配置为提取溶解的样品 材料从样品表面。