公开(公告)号：WO2006135811A2

公开(公告)日：2006-12-21

申请号：PCT/US2006/022629

申请日：2006-06-09

Applicant: UNIVERSITY OF MARYLAND - BALTIMORE ,  ALBA THERAPEUTICS CORP. ,  FASANO, Alessio ,  PATERSON, Blake ,  SAPONE, Anna

Inventor： FASANO, Alessio ,  PATERSON, Blake ,  SAPONE, Anna

IPC: A61K38/22 ,  A61K38/18

CPC classification number: A61K35/39 ,  A61K38/08 ,  A61K38/18 ,  A61K2300/00

Abstract: The present invention provides materials and methods for the treatment of diabetes. Using the materials and methods of the invention, the loss of pancreatic β-cells can be slowed and/or prevented. In addition!, the materials and methods of the invention can be used to regenerate pancreatic β-cells.

Abstract translation: 本发明提供了治疗糖尿病的材料和方法。 使用本发明的材料和方法，可以减缓和/或阻止胰腺β细胞的丧失。 此外，本发明的材料和方法可用于再生胰腺β细胞。

公开(公告)号：WO2010144140A2

公开(公告)日：2010-12-16

申请号：PCT/US2010/001670

申请日：2010-06-10

Applicant: UNIVERSITY OF MARYLAND, BALTIMORE ,  FASANO, Alessio ,  LAMMERS, Karen ,  SHEA-DONOHUE, Terez ,  GOLDBLUM, Simeon

Inventor： FASANO, Alessio ,  LAMMERS, Karen ,  SHEA-DONOHUE, Terez

IPC: A61K39/395 ,  A61K31/7105 ,  A61P3/10 ,  A61P1/04 ,  A61P37/00

CPC classification number: A61K31/7105

Abstract: The present invention provides a method of treating an autoimmune disease, comprising the steps of increasing transepithelial electrical resistance leading to decreased cell permeability. Further provided is ajnethod of treating celiac disease in an individual in need of such treatment, comprising the steps of: administering an antibody directed against single chain zonulin thereby inhibiting epidermal growth factor receptor and inhibiting PAR 2 .

Abstract translation: 本发明提供一种治疗自身免疫疾病的方法，包括增加跨上皮电阻，导致细胞渗透性降低的步骤。 还提供了在需要这种治疗的个体中治疗乳糜泻的方法，包括以下步骤：施用针对单链佐酮的抗体，从而抑制表皮生长因子受体并抑制PAR2。

公开(公告)号：WO2008021879A2

公开(公告)日：2008-02-21

申请号：PCT/US2007/075475

申请日：2007-08-08

Applicant: UNIVERSITY OF MARYLAND, BALTIMORE ,  FASANO, Alessio ,  KRYSZAK, Deborah ,  BAI, Julio, C.

Inventor： FASANO, Alessio ,  KRYSZAK, Deborah ,  BAI, Julio, C.

IPC: G01N33/00 ,  G01N33/564

CPC classification number: G01N33/564 ,  G01N33/6893 ,  G01N2800/06

Abstract: The present invention provides materials and methods to diagnose celiac disease. In some embodiments, the present invention provides a method of diagnosing celiac disease by measuring the serum zonulin level of a subject.

Abstract translation: 本发明提供了诊断乳糜泻的材料和方法。 在一些实施方案中，本发明提供了通过测量受试者的血清zonulin水平来诊断乳糜泻的方法。

公开(公告)号：WO2007124354A3

公开(公告)日：2007-11-01

申请号：PCT/US2007/066957

申请日：2007-04-19

Applicant: ALBA THERAPEUTICS CORP. ,  FASANO, Alessio ,  PATERSON, Blake

Inventor： FASANO, Alessio ,  PATERSON, Blake

IPC: A61K39/00 ,  A61K38/16 ,  A61K38/04

Abstract: The present invention provides materials and methods to facilitate the pulmonary delivery of therapeutic agents. In some embodiments, agonists of tight junctions ( e.g. , zonulin agonists) are used in compositions to facilitate the uptake of therapeutic agents from the pulmonary mucosa.

公开(公告)号：WO2006076587A2

公开(公告)日：2006-07-20

申请号：PCT/US2006001254

申请日：2006-01-13

Applicant: UNIV MARYLAND ,  INST SUPERIORE DE SANITA ,  DE MAGISTRIS MARIA ,  FASANO ALESSIO

Inventor： DE MAGISTRIS MARIA ,  FASANO ALESSIO

IPC: A61K39/295

CPC classification number: A61K39/39 ,  A61K39/00 ,  A61K2039/541 ,  A61K2039/543 ,  A61K2039/55544

Abstract: The present invention is directed to a adjuvant peptide and uses to facilitate antigen absorption in the mucosa, particularly nasal tissue. Vaccine compositions for mucosal delivery include the adjuvant peptide and an antigen for inducing an immune response.

Abstract translation: 本发明涉及一种佐剂肽，并且用于促进粘膜特别是鼻组织中的抗原吸收。 用于粘膜递送的疫苗组合物包括佐剂肽和用于诱导免疫应答的抗原。