公开(公告)号：WO2013034989A2

公开(公告)日：2013-03-14

申请号：PCT/IB2012/002626

申请日：2012-09-07

Applicant: 3-D MATRIX, LTD. ,  NATIONAL CANCER CENTER RESEARCH INSTITUTE ,  OCHIYA, Takahiro ,  FUJIWARA, Tomohiro

Inventor： OCHIYA, Takahiro ,  FUJIWARA, Tomohiro

IPC: A61K48/00

CPC classification number: C12N15/113 ,  A61B5/055 ,  A61B5/4504 ,  A61B6/032 ,  A61B6/505 ,  A61B10/025 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2310/3231 ,  C12N2320/11 ,  C12N2320/31 ,  C12Q1/6886 ,  C12Q2600/178 ,  G01N33/5011

Abstract: Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR- 133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.

Abstract translation: 提供用于骨肉瘤的诊断，治疗和监测的方法和组合物。 发现与癌症干细胞（CSCs）或骨肉瘤的肿瘤起始细胞（TIC）相关的某些microRNA（miRNA）的反义对于抑制肿瘤生长和转移以及延长存活是有用的。 针对miR-133a的反义寡核苷酸与标准化疗例如顺铂组合协同治疗骨肉瘤。