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公开(公告)号：WO2016094829A8
公开(公告)日：2017-07-06
申请号：PCT/US2015065302
申请日：2015-12-11
Applicant: 3-D MATRIX LTD , GILBERT KARL PATRICK
Inventor： GILBERT KARL PATRICK , GIL EUN SEOK , RIOULT MARC , NAGANO KEIJI , KIYOFUJI TOSHIRO , HASEGAWA YUYA
CPC classification number: A61L27/52 , A61L27/227 , A61L27/54 , A61L2300/25 , C07K7/08 , C07K14/001
Abstract: Compositions, peptide solutions and macroscopic scaffolds of self-assembling peptides consisting essentially of non-ionic, polar amino acids are provided. Particular peptides include those comprising, or consisting essentially of, serine, threonine, tyrosine, cysteine, glutamine, asparagine, methionine, tryptophan, hydroxy-proline, and combinations thereof. Methods of sterilizing the self-assembling peptides, and scaffolds comprising the peptides are also provided.
Abstract translation: 提供了基本上由非离子极性氨基酸组成的自组装肽的组合物，肽溶液和宏观支架。 具体的肽包括那些包含丝氨酸，苏氨酸，酪氨酸，半胱氨酸，谷氨酰胺，天冬酰胺，甲硫氨酸，色氨酸，羟基脯氨酸及其组合的丝氨酸或其组合。 还提供了使自组装肽消毒的方法和包含肽的支架。
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公开(公告)号：WO2015194194A1
公开(公告)日：2015-12-23
申请号：PCT/JP2015/003096
申请日：2015-06-19
Applicant: 3-D MATRIX, LTD.
Inventor： SPIRIO, Lisa , GIL, Eun Seok
CPC classification number: A61L27/227 , A61F2/28 , A61F2002/2817 , A61F2002/2839 , A61K38/00 , A61L27/3608 , A61L27/365 , A61L27/50 , A61L27/52 , A61L2400/06 , A61L2400/12 , A61L2430/02 , A61L2430/12
Abstract: Materials and methods for bone void filling are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. The peptide may undergo self-organization under physiological conditions and/or in the presence of a cation.
Abstract translation: 提供骨填充的材料和方法。 在溶液中含有约7个氨基酸和约32个氨基酸之间的肽可被引入到靶位点。 肽可以在生理条件下和/或在阳离子存在下进行自组织。
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公开(公告)号：WO2015138475A1
公开(公告)日：2015-09-17
申请号：PCT/US2015/019740
申请日：2015-03-10
Applicant: 3-D MATRIX, LTD. , MEHTA, Manav , TSUKADA, Hisashi
Inventor： MEHTA, Manav , TSUKADA, Hisashi , GIL, Eun, Seok , GILBERT, Karl, Patrick , KOBAYASHI, Satoru
CPC classification number: A61L31/047 , A61B17/12104 , A61B17/12181 , A61B17/12186 , A61K38/07 , A61K49/006 , A61L31/028 , A61L31/14 , A61L31/145 , A61L31/16 , A61L2300/442 , A61L2400/06 , A61L2400/12 , A61L2430/36
Abstract: Materials and methods for forming a bronchial obstruction are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. A hydrogel barrier may be provided at the target site in order to provide a bronchial obstruction.
Abstract translation: 提供了形成支气管阻塞的材料和方法。 在溶液中含有约7个氨基酸和约32个氨基酸之间的肽可被引入到靶位点。 可以在目标部位提供水凝胶屏障，以便提供支气管阻塞。
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公开(公告)号：WO2017210421A1
公开(公告)日：2017-12-07
申请号：PCT/US2017/035431
申请日：2017-06-01
Applicant: 3-D MATRIX, LTD. , GIL, Eun, Seok , ALEKSI, Elton
Inventor： GIL, Eun, Seok , ALEKSI, Elton , RIOULT, Marc
IPC: A61L15/26 , A61L15/28 , A61L15/32 , A61L15/42 , A61L15/44 , A61L15/64 , A61L24/00 , A61L24/04 , A61L24/08 , A61L24/10 , A61L26/00
Abstract: Hemostatic powders are synergistically used in conjunction with self-assembling peptide hydrogels to promote hemostasis at a target site. Related methods, kits, and devices for hemostasis are disclosed.
Abstract translation: 止血粉末与自组装肽水凝胶协同使用以促进目标部位的止血。 披露了相关的方法，试剂盒和用于止血的装置。
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公开(公告)号：WO2017158432A1
公开(公告)日：2017-09-21
申请号：PCT/IB2017/000366
申请日：2017-03-17
Applicant: 3-D MATRIX, LTD.
Inventor： KOBAYASHI, Satoru
Abstract: Methods and materials for occluding a pancreatic fistula are described herein. One method for occluding a pancreatic fistula includes administering an effective amount of a self- assembling peptide solution to a pancreatic fistula, where the self-assembling peptide is between about 7 amino acids and 32 amino acids in length and the self-assembling peptide solution forms a hydrogel under physiological conditions, thereby occluding the pancreatic fistula.
Abstract translation: 本文描述了用于闭塞胰瘘的方法和材料。 一种用于封堵胰瘘的方法包括将有效量的自组装肽溶液施用于胰瘘，其中自组装肽的长度在约7个氨基酸至32个氨基酸之间，并且自组装肽溶液形成 生理条件下的水凝胶，从而阻塞胰瘘。
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Patent Agency Ranking
公开(公告)号：WO2017158420A1
公开(公告)日：2017-09-21
申请号：PCT/IB2017/000312
申请日：2017-03-17
Applicant: 3-D MATRIX, LTD.
Inventor： KOBAYASHI, Satoru
Abstract: Methods and materials for mitigating biological tissue adhesion are described herein. One method for mitigating adhesion to a biological tissue includes administering an effective amount of a self-assembling peptide solution to the biological tissue, wherein the self- assembling peptide is between about 7 amino acids and 32 amino acids in length and the self- assembling peptide solution forms a hydrogel under physiological conditions.
Abstract translation: 本文描述了用于减轻生物组织粘连的方法和材料。 一种减轻对生物组织的粘附的方法包括给予生物组织有效量的自组装肽溶液，其中自组装肽的长度在约7个氨基酸至32个氨基酸之间，并且自组装肽 溶液在生理条件下形成水凝胶。
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7.发明申请
公开(公告)号：WO2016138274A1
公开(公告)日：2016-09-01
申请号：PCT/US2016/019578
申请日：2016-02-25
Applicant: 3-D MATRIX, LTD. , GILBERT, Karl, Patrick
Inventor： GILBERT, Karl, Patrick , GIL, Eun, Seok
IPC: C12N5/00
CPC classification number: C12N5/0068 , C12N5/0062 , C12N2533/50 , C12N2539/00
Abstract: Synthetic peptide hydrogel solutions having a pH level of about 3.5 or less and a tonicity within an isotonic osmolality range for use in cell culture experimentation. Related kits and cell culture methods are also disclosed.
Abstract translation: 具有约3.5或更低的pH值的合成肽水凝胶溶液和用于细胞培养实验的等张渗透压浓度范围内的张力。 还公开了相关试剂盒和细胞培养方法。
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公开(公告)号：WO2013034989A3
公开(公告)日：2013-06-06
申请号：PCT/IB2012002626
申请日：2012-09-07
Applicant: 3 D MATRIX LTD , NAT CANCER CT , OCHIYA TAKAHIRO , FUJIWARA TOMOHIRO
Inventor： OCHIYA TAKAHIRO , FUJIWARA TOMOHIRO
IPC: C12N15/09 , A61K48/00 , A61P35/00 , C12N15/113 , C12Q1/68
CPC classification number: C12N15/113 , A61B5/055 , A61B5/4504 , A61B6/032 , A61B6/505 , A61B10/025 , C12N2310/113 , C12N2310/141 , C12N2310/3231 , C12N2320/11 , C12N2320/31 , C12Q1/6886 , C12Q2600/178 , G01N33/5011
Abstract: Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR- 133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.
Abstract translation: 提供了用于诊断，治疗和监测骨肉瘤的方法和组合物。 发现与癌症干细胞（CSCs）或肿瘤起始细胞（TIC）相关的某些微小RNA（miRNA）对于骨肉瘤的反义有利于抑制肿瘤的生长和转移，延长生存期。 miR-133a的反义寡核苷酸与标准化疗如顺铂联合用于治疗骨肉瘤。
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公开(公告)号：WO2017120092A1
公开(公告)日：2017-07-13
申请号：PCT/US2016/069133
申请日：2016-12-29
Applicant: 3-D MATRIX, LTD. , VICUS THERAPEUTICS, LLC
Inventor： MAKI, John , GIL, Eun Seok , SPIRIO, Lisa
CPC classification number: A61K38/08 , A61K9/0019 , A61K38/10 , A61K47/42 , A61L27/227
Abstract: Combination compositions comprising self-assembling peptides and payload agents, and methods of making and using such compositions, are described.
Abstract translation: 描述了包含自组装肽和有效载荷剂的组合组合物，以及制备和使用该组合物的方法。
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公开(公告)号：WO2016094829A1
公开(公告)日：2016-06-16
申请号：PCT/US2015/065302
申请日：2015-12-11
Applicant: 3-D MATRIX, LTD. , GILBERT, Karl, Patrick
Inventor： GILBERT, Karl, Patrick , GIL, Eun, Seok , RIOULT, Marc , NAGANO, Keiji , KIYOFUJI, Toshiro , HASEGAWA, Yuya
CPC classification number: A61L27/52 , A61L27/227 , A61L27/54 , A61L2300/25 , C07K7/08 , C07K14/001
Abstract: Compositions, peptide solutions and macroscopic scaffolds of self-assembling peptides consisting essentially of non-ionic, polar amino acids are provided. Particular peptides include those comprising, or consisting essentially of, serine, threonine, tyrosine, cysteine, glutamine, asparagine, methionine, tryptophan, hydroxy-proline, and combinations thereof. Methods of sterilizing the self-assembling peptides, and scaffolds comprising the peptides are also provided.
Abstract translation: 提供了基本上由非离子型极性氨基酸组成的自组装肽的组合物，肽溶液和宏观支架。 具体的肽包括丝氨酸，苏氨酸，酪氨酸，半胱氨酸，谷氨酰胺，天冬酰胺，甲硫氨酸，色氨酸，羟基 - 脯氨酸，或其组合的丝氨酸，苏氨酸，酪氨酸， 还提供了对自组装肽进行灭菌的方法，以及包含肽的支架。
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