公开(公告)号：WO2016162437A1

公开(公告)日：2016-10-13

申请号：PCT/EP2016/057652

申请日：2016-04-07

Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG) ,  HEXAL AG

Inventor： VAMSHI RAMANA, Prathap ,  NAIDU KALAMATA, Venkatasimhadri ,  CHARY RALLABANDI, Bala, Ramesha

IPC: A61K9/20 ,  A61K9/28

CPC classification number: A61K9/2018 ,  A61K9/2013 ,  A61K9/2054 ,  A61K9/284

Abstract: The present invention relates to an immediate-release solid pharmaceutical composition for oral administration containing ivabradine oxalate, and furthermore, to the use of an antioxidant for preventing chemical degradation of ivabradine oxalate in a solid pharmaceutical composition.

Abstract translation: 本发明涉及用于口服给药的立即释放固体药物组合物，其含有草丁酸伊伐布拉定，此外，涉及在固体药物组合物中使用抗氧化剂以防止草酸伊伐溴酸的化学降解。

公开(公告)号：WO2014090386A1

公开(公告)日：2014-06-19

申请号：PCT/EP2013/003692

申请日：2013-12-06

Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG)

Inventor： GUJJAR, Chaitanya Yogananda ,  RALLABANDI, Bala Ramesha Chary Rallabandi ,  PATWARI, Pradip Shivraj ,  FITZNER, Ansgar

IPC: A61K9/20 ,  A61K31/407

CPC classification number: A61K31/407 ,  A61K9/0053 ,  A61K9/0056 ,  A61K9/2013 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2077 ,  A61K9/2095

Abstract: The present invention relates to an orally disintegrating tablet (ODT) containing asenapine maleate and to a process for preparing the ODT. In a first aspect, the present invention relates to an ODT containing asenapine maleate and low substituted hydroxypropylcellulose. In a second aspect, the present invention relates to an ODT containing crystalline asenapine maleate and the ODT is prepared using conventional tabletting techniques as direct compression and granulation. In a third aspect, the present invention relates to an ODT containing asenapine maleate and a carboxylic acid, and to the use of a carboxylic acid for enhancing storage stability of an asenapine maleate containing ODT.

Abstract translation: 本发明涉及含有马来酸二氮芥的口腔崩解片（ODT）及其制备方法。 在第一方面，本发明涉及含有马来酸asenapine和低取代羟丙基纤维素的ODT。 在第二方面，本发明涉及含有结晶阿拉芬那马来酸盐的ODT，并且使用常规压片技术制备ODT作为直接压制和造粒。 在第三方面，本发明涉及含有马来酸亚甲酯和羧酸的ODT，以及使用羧酸来提高含有ODT的马来酸阿萘那平的储存稳定性。

公开(公告)号：WO2013104546A1

公开(公告)日：2013-07-18

申请号：PCT/EP2013/000071

申请日：2013-01-11

Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG) ,  SHANGHAI GOLDEN PHARMATECH CO., LTD.

Inventor： MAO, Zhenmin ,  LAN, Tian ,  LIU, Lanfang ,  YAN, Long ,  BECKER, Stefan

IPC: C07D213/46 ,  C07D213/61

CPC classification number: C07D401/04 ,  C07D213/46 ,  C07D213/61

Abstract: The present invention relates to a process for the synthesis of the anti-inflammatory agent 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl-[2,3']bipyridine, referred to as compound of formula (1) or etoricoxib, which is a pharmaceutically active ingredient inhibiting cyclooxygenase-2. In particular, the application concerns a novel process of making the compound of formula (1) by oxidizing a compound of formula (4).

Abstract translation: 本发明涉及一种合成抗炎剂5-氯-3-（4-甲磺酰基苯基）-6'-甲基 - [2,3']联吡啶的方法，称为式（1）化合物， 或依托昔昔，其是抑制环氧合酶-2的药物活性成分。 特别地，本申请涉及通过氧化式（4）化合物来制备式（1）化合物的新方法。

公开(公告)号：WO2012139736A1

公开(公告)日：2012-10-18

申请号：PCT/EP2012/001522

申请日：2012-04-05

Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG) ,  GUJJAR, Chaitanya Yogananda ,  RALLABANDI, Bala Ramesha Chary ,  PASAHN, Manohar Lal ,  RILLMANN, Thomas

Inventor： GUJJAR, Chaitanya Yogananda ,  RALLABANDI, Bala Ramesha Chary ,  PASAHN, Manohar Lal ,  RILLMANN, Thomas

IPC: A61K9/20 ,  A61K9/28 ,  A61P9/12

CPC classification number: A61K9/2054 ,  A61K9/2018 ,  A61K9/2059 ,  A61K9/2866

Abstract: The present invention relates to a stable solid pharmaceutical composition comprising or consisting of bosentan or a pharmaceutically acceptable salt thereof, a first diluent or filler which is a cellulose derivative and a second diluent or filler which is different from the first diluent as well as a process for manufacturing the inventive pharmaceutical composition.

Abstract translation: 本发明涉及包含波生坦或其药学上可接受的盐，作为纤维素衍生物的第一稀释剂或填充剂和与第一稀释剂不同的第二稀释剂或填料的稳定的固体药物组合物， 用于制造本发明的药物组合物。