公开(公告)号：WO2005095395A2

公开(公告)日：2005-10-13

申请号：PCT/JP2005/006895

申请日：2005-04-01

Applicant: TANABE SEIYAKU CO., LTD. ,  KUBOTA, Hitoshi ,  NAKAMURA, Yoshinori ,  HIGASHIJIMA, Takanori ,  YAMAMOTO, Yasuo ,  OKA, Kozo ,  IGARASHI, Shigeki

Inventor： KUBOTA, Hitoshi ,  NAKAMURA, Yoshinori ,  HIGASHIJIMA, Takanori ,  YAMAMOTO, Yasuo ,  OKA, Kozo ,  IGARASHI, Shigeki

IPC: C07D471/00

CPC classification number: C07D471/04

Abstract: A novel compound of the formula (I): wherein R 1 is alkoxycarbonyl or the like, R 2 is alkyl or the like; R 3 is hydrogen or the like; R 4 is alkylene or the like; R 5 is optionally substituted heterocyclic group; R 6 , R 7 , and R 8 are independently hydrogen; alkyl, alkoxy, or the like; R10 is optionally substituted aromatic ring, or the like; or a pharmaceutically acceptable salt thereof, which has an inhibitory activity against cholesteryl ester transfer protein (CETP).

Abstract translation: 式（I）的新化合物：其中R 1是烷氧基羰基等，R 2是烷基等; R 3是氢等; R 4是亚烷基等; R 5是任选取代的杂环基; R 6，R 7和R 8独立地是氢; 烷基，烷氧基等; R10是任选取代的芳环，等等; 或其药学上可接受的盐，其具有对胆固醇酯转移蛋白（CETP）的抑制活性。

公开(公告)号：WO2005089774A1

公开(公告)日：2005-09-29

申请号：PCT/JP2005/005452

申请日：2005-03-17

Applicant: TANABE SEIYAKU CO., LTD. ,  YAMAMURA, Michio ,  HAYASHIDA, Koukichi ,  TSUCHIDA, Toshito

Inventor： YAMAMURA, Michio ,  HAYASHIDA, Koukichi ,  TSUCHIDA, Toshito

IPC: A61K31/7004

CPC classification number: A61K31/7004

Abstract: An agent for improving depression-like symptoms comprising D-ribose, which may improve and alleviate various symptoms such as hypobulia, general fatigue, sluggishness, enervation, deterioration in concentration, memory impairment, abnormal sensation/obtundation such as impaired sight, decline in thinking power, indefinite complaint, drop in operation efficiency, or feeling of malaise, etc.

Abstract translation: 用于改善抑郁症状的药物，其包含D-核糖，其可以改善和减轻各种症状，例如低血压，一般疲劳，迟钝，消耗，浓度变差，记忆障碍，视力受损，视力下降等异常感觉/抑制 权力，无限期投诉，运作效率下降或不适感等。

公开(公告)号：WO2005075438A1

公开(公告)日：2005-08-18

申请号：PCT/JP2005/002194

申请日：2005-02-08

Applicant: TANABE SEIYAKU CO., LTD. ,  WARD, Robert, William ,  WITHERINGTON, Jason

Inventor： WARD, Robert, William ,  WITHERINGTON, Jason

IPC: C07D237/14

CPC classification number: C07D237/14 ,  C07D239/36 ,  C07D241/18

Abstract: The present invention relates to novel compounds of formula (I), processes for their preparation, compositions comprising them and their use in the treatment or prevention of diseases capable of being modulated by the inhibition of cell adhesion.

Abstract translation: 本发明涉及新的式（I）化合物，其制备方法，包含它们的组合物及其在治疗或预防能够通过抑制细胞粘附而被调节的疾病中的用途。

公开(公告)号：WO2005037271A2

公开(公告)日：2005-04-28

申请号：PCT/JP2004/015662

申请日：2004-10-15

Applicant: TANABE SEIYAKU CO., LTD. ,  IMANISHI, Yasuhiro ,  AWAI, Nobumasa ,  HIRAI, Miki ,  HOSAKA, Toshihiro ,  KONO, Rikako

Inventor： IMANISHI, Yasuhiro ,  AWAI, Nobumasa ,  HIRAI, Miki ,  HOSAKA, Toshihiro ,  KONO, Rikako

IPC: A61K31/415

CPC classification number: C07D231/12 ,  A61K31/415 ,  A61K31/42 ,  C07D231/38 ,  C07D261/08 ,  C07D401/04 ,  C07D403/04 ,  C07D403/12 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: The present invention provides a large conductance calcium-activated K channel opener comprising a compound of the formula (I): wherein R 1 and R 3 are each sulfonamide, carbamoyl, acyl, amino, and the like, m and n are each 0 to 2, R 2 and R 4 are each cyano, nitro, hydroxyl, an alkoxy, a halogen, or an alkyl, Ring A is benzene or a heterocyclic ring, Ring B is benzene, a heterocyclic ring, a cycloalkane etc, and Ring Q is pyrazole or isoxazole, or a pharmaceutically acceptable salt thereof as an active ingredient.

Abstract translation: 本发明提供了大电导钙活化的K通道开放剂，其包含式（I）的化合物：其中R 1和R 3分别是 各自为磺酰胺，氨基甲酰基，酰基，氨基等，m和n各自为0-2，R 2和R 4各自为氰基，硝基，羟基 ，烷氧基，卤素或烷基，环A为苯或杂环，环B为苯，杂环，环烷等，且环Q为吡唑或异恶唑或其药学上可接受的盐作为活性成分 成分

公开(公告)号：WO2004011640A1

公开(公告)日：2004-02-05

申请号：PCT/JP2003/009523

申请日：2003-07-28

Applicant: TANABE SEIYAKU CO., LTD. ,  HIRAMATSU, Hajime ,  KYONO, Kiyoshi ,  SHIMA, Hideaki ,  SUGIYAMA, Shigeru

Inventor： HIRAMATSU, Hajime ,  KYONO, Kiyoshi ,  SHIMA, Hideaki ,  SUGIYAMA, Shigeru

IPC: C12N9/48

CPC classification number: C07K14/70596 ,  C07K2299/00 ,  C12N9/48 ,  C12Y304/14005

Abstract: A crystal of a dipeptidyl peptidase IV; a three-dimensional structural coordinate of the dipeptidyl peptidase IV; a method for obtaining a three-dimensional coordinate of a homolog protein of the dipeptidyl peptidase IV; a method for obtaining a three-dimensional structural coordinate of a crystal of a complex of the dipeptidyl peptidase IV and a effector of the dipeptidyl peptidase IV; a method for identifying pharmacophore of the effector of the dipeptidyl peptidase IV; a method for designing, identifying, evaluating or searching; the effector; and a program and a medium therefor for use of the three-dimensional structural coordinate.

Abstract translation: 二肽基肽酶IV的晶体; 二肽基肽酶IV的三维结构坐标; 获得二肽基肽酶IV的同源蛋白质的三维坐标的方法; 用于获得二肽基肽酶IV和二肽基肽酶IV的效应子的复合物的晶体的三维结构坐标的方法; 用于鉴定二肽基肽酶IV的效应子的药效团的方法; 一种设计，识别，评估或搜索的方法; 效应器 以及用于使用三维结构坐标的程序和介质。

公开(公告)号：WO2003086471A2

公开(公告)日：2003-10-23

申请号：PCT/JP2003/004745

申请日：2003-04-15

Applicant: TANABE SEIYAKU CO., LTD. ,  ITO, Takahiro ,  NARISAWA, Shinji

Inventor： ITO, Takahiro ,  NARISAWA, Shinji

IPC: A61K47/48

CPC classification number: A61K9/0019 ,  A61K47/02 ,  A61K47/12 ,  A61K47/61 ,  A61K47/65

Abstract: The present invention relates to a stable liquid preparation comprising a camptothecin derivative which is prepared by binding a compound of the formula [I]:wherein R 1 is a substituted or unsubstituted lower alkyl group, X 1 is a group of the formula: -NHR 2 (R 2 is a hydrogen atom or a lower alkyl group) or a hydroxy group and Alk is a straight or branched chain alkylene group optionally interrupted by an oxygen atom, and a polysaccharide having carboxyl groups via an amino acid or a peptide, or a pharmaceutically acceptable salt thereof, which is adjusted to pH 5-8, or a stable pharmaceutical composition produced by lyophilizing said liquid preparation.

Abstract translation: 本发明涉及一种稳定的液体制剂，其包含通过结合式[I]化合物制备的喜树碱衍生物：其中R 1是取代或未取代的低级烷基，X> 1是 式：-NHR> 2 <（R 2>是氢原子或低级烷基）或羟基，Alk是任选被氧原子间隔的直链或支链亚烷基，和具有羧基通过的多糖 调节至pH 5-8的氨基酸或肽或其药学上可接受的盐，或通过冻干所述液体制剂而制备的稳定的药物组合物。

公开(公告)号：WO1998029409A1

公开(公告)日：1998-07-09

申请号：PCT/JP1997004826

申请日：1997-12-25

Applicant: UBE INDUSTRIES, LTD. ,  TANABE SEIYAKU CO., LTD. ,  KITA, Jun-ichiro ,  FUJIWARA, Hiroshi ,  TAKAMURA, Shinji ,  YOSHIOKA, Ryuzo ,  OZAKI, Yauhiko ,  YAMADA, Shin-ichi

Inventor： UBE INDUSTRIES, LTD. ,  TANABE SEIYAKU CO., LTD.

IPC: C07D401/12

CPC classification number: C07D401/12

Abstract: Benzenesulfonate and benzoate of (S)-4-[4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino]butanoic acid of formula (1) (wherein * represents an asymmetric carbon atom) which are excellent in antihistaminic and antiallergic activities, and a process for producing them.

Abstract translation: （S）-4- [4 - [（4-氯苯基）（2-吡啶基）甲氧基]哌啶子基]丁酸（其中*表示不对称碳原子）的苯磺酸盐和苯甲酸酯，其抗组胺和 抗过敏活性及其制备方法。

公开(公告)号：WO1996040781A1

公开(公告)日：1996-12-19

申请号：PCT/US1996010186

申请日：1996-06-06

Applicant: TANABE SEIYAKU CO., LTD. ,  LOBL, Thomas, J. ,  CHIANG, Shiu-Lan ,  SCHOLZ, Wolfgang ,  DELAET, Nancy ,  CARDARELLI, Pina

Inventor： TANABE SEIYAKU CO., LTD.

IPC: C07K14/78

CPC classification number: C07K7/02 ,  A61K38/00 ,  C07K14/78

Abstract: The present invention describes cyclic peptide compounds which modulate integrin mediated adhesion. These compounds can inhibit both beta 1 and beta 2 mediated adhesion. The invention further relates to therapeutic uses for these compounds in the treatment of adhesion related pathologies.

Abstract translation: 本发明描述了调节整联蛋白介导的粘附的环肽化合物。 这些化合物可以抑制β1和β2介导的粘附。 本发明还涉及这些化合物在治疗粘连相关病理学中的治疗用途。

公开(公告)号：WO1994015958A2

公开(公告)日：1994-07-21

申请号：PCT/IB1994000026

申请日：1994-01-07

Applicant: TANABE SEIYAKU CO., LTD.

Inventor： TANABE SEIYAKU CO., LTD. ,  CHIANG, Shiu-Lang Ng ,  CARDARELLI, Pina, M. ,  LOBL, Thomas, J.

IPC: C07K05/10

CPC classification number: C07K7/06 ,  A61K38/00 ,  C07K7/02 ,  C07K7/56 ,  C07K14/78

Abstract: Cyclized integrin receptor antagonists useful in modulating cell adhesion, including adhesion related to fibronectin, as well as leukocyte adhesion to endothelial cells, are disclosed. Methods for synthesizing, testing, formulating, and using the compounds as therapeutic agents are also disclosed.

Abstract translation: 公开了可用于调节细胞粘附的环化的整联蛋白受体拮抗剂，包括与纤连蛋白相关的粘附，以及对内皮细胞的白细胞粘附。 还公开了用于合成，测试，配制和使用化合物作为治疗剂的方法。

公开(公告)号：WO2007088999A1

公开(公告)日：2007-08-09

申请号：PCT/JP2007/051868

申请日：2007-01-30

Applicant: TANABE SEIYAKU CO., LTD. ,  NAKAMURA, Yoshinori ,  HAYASHI, Norimitsu ,  HIGASHIJIMA, Takanori ,  KUBOTA, Hitoshi ,  OKA, Kozo

Inventor： NAKAMURA, Yoshinori ,  HAYASHI, Norimitsu ,  HIGASHIJIMA, Takanori ,  KUBOTA, Hitoshi ,  OKA, Kozo

IPC: C07D401/12 ,  A61K31/505 ,  A61P3/06

CPC classification number: C07D401/12

Abstract: The present invention relates to a compound of the general formula (1): wherein, Y is a methylene group, and the like; A is an optionally substituted heterocyclic group, and the like; B is an optionally substituted heterocyclic group, and the like; R 1 is an optionally substituted alkyl group, wherein the alkyl group further may optionally be substituted by an optionally substituted homocyclic group, and the like; and R 2 is an optionally substituted amino group, and the like; or a pharmaceutically acceptable derivative thereof, which has an inhibitory activity against cholesteryl ester transfer protein (CETP), thereby being useful for prophylaxis and/or treatment of arteriosclerotic diseases, hyperlipemia or dyslipidemia, and the like.

Abstract translation: 本发明涉及通式（1）的化合物：其中Y为亚甲基等; A是任选取代的杂环基等; B是任选取代的杂环基等; R 1是任选取代的烷基，其中烷基进一步可以任选地被任选取代的杂环基取代，等等; 和R 2是任选取代的氨基等; 或其药学上可接受的衍生物，其对胆固醇酯转移蛋白（CETP）具有抑制活性，因此可用于预防和/或治疗动脉硬化性疾病，高脂血症或血脂异常等。