公开(公告)号：WO1995010301A1

公开(公告)日：1995-04-20

申请号：PCT/SE1994000941

申请日：1994-10-07

申请人： HOLMGREN, Jan ,  CZERKINSKY, Cecil

IPC分类号： A61K39/385

CPC分类号： A61K39/001 ,  A61K39/0008 ,  A61K47/646 ,  A61K2039/542 ,  A61K2039/6037 ,  Y10S424/81 ,  Y10S514/828 ,  Y10S514/885 ,  Y10S530/868

摘要： An immunological tolerance-inducing agent comprising a mucosabinding molecule linked to a specific tolerogen is disclosed. Further, a method of inducing immunological tolerance in an individual against a specific antigen, including hapten, which causes an unwanted immune response in said individual comprising administration by a mucosal route of an immunologically effective amount of an immunological tolerance-inducing agent of the invention to said individual, is described.

摘要翻译： 公开了包含与特异性耐受原相连的粘膜粘附分子的免疫耐受诱导剂。 此外，一种针对特定抗原（包括半抗原）诱导免疫耐受的方法，其引起所述个体中的不需要的免疫应答，包括通过粘膜途径施用免疫有效量的本发明的免疫耐受诱导剂至 说个人，被描述。

公开(公告)号：WO1995007985A1

公开(公告)日：1995-03-23

申请号：PCT/GB1994002006

申请日：1994-09-14

申请人： NATIONAL HEART & LUNG INSTITUTE ,  LUDWIG INSTITUTE FOR CANCER RESEARCH ,  WILLIAMS, Timothy, John ,  JOSE, Peter, John ,  GRIFFITHS-JOHNSON, David, A. ,  HSUAN, John, Justin

发明人： NATIONAL HEART & LUNG INSTITUTE ,  LUDWIG INSTITUTE FOR CANCER RESEARCH

IPC分类号： C12N15/19

CPC分类号： G01N33/6863 ,  C07K14/523 ,  G01N2333/715 ,  G01N2800/122 ,  G01N2800/24 ,  Y10S514/885

摘要： A chemoattractant protein called "eotaxin" is capable of attracting eosinophils and of inducing eosinophil accumulation and/or activation in vitro and in vivo. Various types of agents that inhibit or otherwise hinder the production, release or activity of eotaxin may be used therapeutically in the treatment of asthma and other inflammatory diseases.

摘要翻译： 称为“嗜酸细胞活化趋化因子”的化学引诱物蛋白质能够吸引嗜酸性粒细胞并在体外和体内诱导嗜酸性粒细胞积累和/或激活。 抑制或以其它方式阻碍嗜酸细胞活化趋化因子的产生，释放或活性的各种试剂可用于治疗哮喘和其它炎性疾病。

公开(公告)号：WO1994019012A2

公开(公告)日：1994-09-01

申请号：PCT/US1994001913

申请日：1994-02-23

申请人： WANG, Jui, H.

发明人： KANG, Insung ,  RAHAM, Mohammed, H.

IPC分类号： A61K39/12

CPC分类号： C07H21/00 ,  Y10S514/885

摘要： Novel polyadenylic acid (5') derivatives with 2'-0-(3-fluoro-4,6-dinitrophenyl) groups and/or 2'-0-(2,4-dinitrophenyl) groups have been synthesized and discovered to act as mutation-insensitive and function-specific inhibitors of viral reverse transcriptase. The compositions, preparative procedures and methods of application of these novel compounds for the treatment of humans carrying or infected with AIDS virus and other RNA-viruses, of other mammals carrying RNA-viruses, for the fast but temporary protection of uninfected humans and other mammals against immuno-deficiency viruses and other RNA-virus caused diseases, for the preparation of a formulation containing irreversibly sterilized HIV or other RNA-viruses useful as anti-AIDS and anti-other RNA-virus disease vaccines, for the complete sterilization of possible trace amounts of live HIV and other RNA-viruses in stored transfusion blood, and for the inactivation or removal of trace amounts of ribonuclease in solution and containers used in biotechnology processes have all been disclosed.

摘要翻译： 已经合成了具有2'-O-（3-氟-4,6-二硝基苯基）基团和/或2'-O-（2,4-二硝基苯基）基团的新型聚腺苷酸（5'）衍生物， 病毒逆转录酶的突变不敏感和功能特异性抑制剂。 用于治疗携带或感染艾滋病病毒和其他RNA病毒的其他携带RNA病毒的哺乳动物的这些新化合物的组合物，制备方法和方法用于快速但临时保护未感染的人和其他哺乳动物 针对免疫缺陷病毒和其他RNA病毒引起的疾病，用于制备含有不可逆灭菌的HIV或其它可用作抗艾滋病和抗其他RNA病毒病疫苗的其他RNA病毒的制剂，用于完全灭菌可能的痕迹 已经公开了存储的输血中的活的HIV和其他RNA病毒的量以及在生物技术过程中使用的溶液和容器中的微量核糖核酸酶的失活或去除。

公开(公告)号：WO1994017104A1

公开(公告)日：1994-08-04

申请号：PCT/US1994000812

申请日：1994-01-21

申请人： THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. ,  HILL, Nicholas, S. ,  THOMPSON, Frederick, N., Jr. ,  DAWE, Donald, L. ,  STUEDEMANN, John, A.

发明人： THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.

IPC分类号： C07K15/00

CPC分类号： A61K39/00 ,  A61K38/00 ,  A61K39/0002 ,  A61K2039/6081 ,  C07K16/16 ,  C07K16/4208 ,  C07K16/44 ,  Y10S514/885 ,  Y10S530/807

摘要： The present invention provides an immunogenic compound comprising formula (I), wherein X is selected from the group consisting of methyl and hydrogen; wherein R1 is a suitable functional group of the lysergic ring; wherein R2 is an immunogenic protein; and wherein Y is a bridge to link R1 to R2. The present invention also provides purified monoclonal antibodies specifically reactive with the immunogenic compound and reactive with the lysergic ring of ergopeptine and clavine alkaloids. The present invention further provides an antibody which is an anti-idiotype of the monoclonal antibody. Also provided are methods of prevention and treatment of fescue toxicosis utilizing the immunogenic compounds and antibodies of the present invention.

摘要翻译： 本发明提供了包含式（I）的免疫原性化合物，其中X选自甲基和氢; 其中R1是所述麦角酸的合适官能团; 其中R2是免疫原性蛋白; 并且其中Y是将R1连接到R2的桥。 本发明还提供了与免疫原性化合物特异性反应并且与麦角霉素和角质碱生物碱的麦角环反应的纯化单克隆抗体。 本发明还提供作为单克隆抗体的抗独特型的抗体。 还提供了利用本发明的免疫原性化合物和抗体预防和治疗羊茅中毒的方法。

公开(公告)号：WO1994007516A1

公开(公告)日：1994-04-14

申请号：PCT/CA1993000414

申请日：1993-10-04

申请人： ALBERTA RESEARCH COUNCIL ,  SMITH, Richard ,  HEERZE, Louis, D. ,  ARMSTRONG, Glen, D.

发明人： ALBERTA RESEARCH COUNCIL

IPC分类号： A61K37/02

CPC分类号： A61K38/47 ,  A61K38/45 ,  C07K14/235 ,  Y10S436/827 ,  Y10S514/885 ,  Y10S530/868

摘要： The present invention is directed to methods of suppressing inflammatory responses, inducing tolerance to an antigen, stimulating immune response to antigens, and suppressing or enhancing cell adhesion, e.g., involved in metastasis, by the administration of carbohydrate binding proteins or fragments or derivatives thereof, in particular, proteins capable of binding (alpha)-2,6 sialic acid structures and/or (alpha)-2,3 sialic acid structures. Pharmaceutical compositions containing such (alpha)-2,6 sialic acid and (alpha)-2,6 sialic acid binding proteins or fragments or derivates thereof are also disclosed.

摘要翻译： 本发明涉及通过施用碳水化合物结合蛋白或其片段或衍生物来抑制炎性反应，诱导对抗原的耐受性，刺激抗原的免疫应答以及抑制或增强细胞粘附，例如参与转移的方法， 特别是能够结合（α）-2,6唾液酸结构和/或（α）-2,3唾液酸结构的蛋白质。 还公开了含有这种（α）-2,6唾液酸和（α）-2,6唾液酸结合蛋白或其片段或衍生物的药物组合物。

公开(公告)号：WO1994007479A2

公开(公告)日：1994-04-14

申请号：PCT/GB1993002039

申请日：1993-09-30

申请人： THE WELLCOME FOUNDATION LIMITED ,  RHODES, John, Richard

发明人： THE WELLCOME FOUNDATION LIMITED

IPC分类号： A61K31/115

CPC分类号： A61K45/06 ,  A61K31/11 ,  A61K31/12 ,  A61K31/155 ,  A61K31/165 ,  A61K31/18 ,  A61K31/19 ,  A61K31/195 ,  A61K31/215 ,  A61K31/235 ,  A61K31/275 ,  A61K31/35 ,  A61K31/365 ,  A61K31/37 ,  A61K31/41 ,  Y10S514/885

摘要： This invention relates to the use of a class of compounds as immunopotentiators, compositions containing such compounds and their manufacture, combinations of such compounds with anti-tumour or anti-infective drugs and the use of such combinations in the prophylaxis or treatment of such diseases arising from tumours or infections.

摘要翻译： 本发明涉及一类化合物作为免疫增强剂的用途，含有这些化合物的组合物及其制备方法，这些化合物与抗肿瘤或抗感染药物的组合以及这些组合在预防或治疗这些疾病中的应用 来自肿瘤或感染。

公开(公告)号：WO1993008814A1

公开(公告)日：1993-05-13

申请号：PCT/US1992009578

申请日：1992-11-05

申请人： KELLOGG COMPANY

发明人： KELLOGG COMPANY ,  NDIFE, Louis, I.

IPC分类号： A61K35/78

CPC分类号： A61K36/68 ,  Y10S514/885 ,  Y10S514/892

摘要： A method of reducing the allergenicity of psyllium seed husk. Psyllium seed husk is treated with an alkaline solution at a temperature and for a time sufficient to reduce the allergenicity of the psyllium seed husk.

公开(公告)号：WO1993007888A1

公开(公告)日：1993-04-29

申请号：PCT/US1992008971

申请日：1992-10-16

申请人： BRIGHAM AND WOMEN'S HOSPITAL

发明人： BRIGHAM AND WOMEN'S HOSPITAL ,  SILBERSTEIN, David, S. ,  MINKOFF, Marjorie

IPC分类号： A61K37/00

CPC分类号： A61K49/0004 ,  A61K38/00 ,  A61K49/0056 ,  C07K14/4703 ,  C07K14/715 ,  G01N33/6863 ,  G01N33/6872 ,  Y10S514/825 ,  Y10S514/885 ,  Y10S514/903 ,  Y10S977/773 ,  Y10S977/904 ,  Y10S977/907 ,  Y10S977/959

摘要： The present invention relates to a molecule (INHIB) which inhibits leukocyte immunological activity, processes for preparing and purifying the molecule, a screening assay, compositions containing INHIB, and diagnostic and therapeutic uses of the molecule. The structure of the INHIB molecule is shown to be substantially similar to the free beta chain of complement C3.

摘要翻译： 本发明涉及抑制白细胞免疫活性的分子（INHIB），制备和纯化分子的方法，筛选试验，含有INHIB的组合物，以及该分子的诊断和治疗用途。 显示INHIB分子的结构基本上与补体C3的游离β链相似。

公开(公告)号：WO9219244A3

公开(公告)日：1992-12-10

申请号：PCT/US9203449

申请日：1992-05-01

申请人： JACKSON H M FOUND MILITARY MED

发明人： PRINCE GREGORY A ,  HEMMING VAL G

IPC分类号： A61K31/19 ,  A61K31/405 ,  A61K31/57 ,  A61K31/575 ,  A61K31/58 ,  A61K31/60 ,  A61K38/00 ,  A61K39/395 ,  A61K39/40 ,  A61K39/42 ,  A61K45/00 ,  A61P29/00 ,  C07K16/24 ,  A61K31/70

CPC分类号： A61K39/40 ,  A61K31/19 ,  A61K31/405 ,  A61K31/57 ,  A61K31/58 ,  A61K31/60 ,  A61K31/70 ,  A61K38/00 ,  A61K39/395 ,  A61K39/42 ,  C07K16/24 ,  Y10S514/885 ,  Y10S514/958 ,  Y10S514/959 ,  A61K2300/00

摘要： A method of treating pneumonia caused by a microorganism by administering directly into the lower respiratory tract of a host an amount of an anti-inflammatory agent effective to reduce inflammation is provided. The method may further include administering to a host an amount of an anti-infectious agent with activity against the microorganism effective to reduce the concentration of the microorganism.

公开(公告)号：WO1992020360A1

公开(公告)日：1992-11-26

申请号：PCT/US1992004074

申请日：1992-05-14

申请人： NORTHWESTERN UNIVERSITY

发明人： NORTHWESTERN UNIVERSITY ,  PATTERSON, Roy ,  HARRIS, Kathleen, E.

IPC分类号： A61K37/00

CPC分类号： A61K38/046 ,  A61K39/35 ,  Y10S424/805 ,  Y10S424/81 ,  Y10S514/885 ,  A61K2300/00

摘要： The present invention relates to a method and preparations for reducing IgE antibodies to allergens in allergic subjects wherein substance P and an allergen or fragments of allergens or haptens acting as allergens are administered together to the allergic subjects. The method can be used to treat humans and animals including dogs, cats, horses and subhuman primates.

摘要翻译： 本发明涉及减轻变应性受试者中过敏原IgE抗体的方法和制剂，其中物质P和变应原或作为变应原的变应原或半抗原的片段一起施用于过敏性受试者。 该方法可用于治疗人类和动物，包括狗，猫，马和非人灵长类动物。