TETRACYCLIC HETEROCYCLES AS ANTIMICROBIAL AGENTS
    51.
    发明申请
    TETRACYCLIC HETEROCYCLES AS ANTIMICROBIAL AGENTS 审中-公开
    作为抗微生物剂的四环杂环化合物

    公开(公告)号:WO00017206A1

    公开(公告)日:2000-03-30

    申请号:PCT/US1999/020930

    申请日:1999-09-10

    CPC分类号: C07D491/10 C07D493/10

    摘要: Methods for treating infection and related compositions, compounds of formula (I) as defined in the application and methods for preparing same, are provided. In general, the compounds inhibit tarnsfer ribonucleic acid (tRNA) synthetase and are useful as antimicrobial agents.

    摘要翻译: 提供了治疗感染和相关组合物的方法,应用中定义的式(I)化合物及其制备方法。 通常,化合物抑制核糖核酸(tRNA)合成酶,并且可用作抗微生物剂。

    ARYL THIOPYRANO[2,3,4-c,d]INDOLES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS
    52.
    发明申请
    ARYL THIOPYRANO[2,3,4-c,d]INDOLES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS 审中-公开
    ARYL THIOPYRANO [2,3,4-c,d]作为紫苏酮生物合成酶的抑制剂

    公开(公告)号:WO1994011378A1

    公开(公告)日:1994-05-26

    申请号:PCT/CA1993000478

    申请日:1993-11-09

    IPC分类号: C07D495/06

    CPC分类号: C07D495/06

    摘要: Compounds having formula (I) are inhibitors of 5-lipoxygenase and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, psoriasis, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.

    摘要翻译: 具有式(I)的化合物是5-脂氧合酶的抑制剂和白三烯生物合成抑制剂。 这些化合物可用作抗哮喘,抗过敏,抗炎和细胞保护剂。 它们也可用于治疗心绞痛,脑痉挛,肾小球性肾炎,肝炎,内毒素血症,牛皮癣,葡萄膜炎和同种异体移植物排斥和预防动脉粥样硬化斑块的形成。