公开(公告)号：WO2009152945A4

公开(公告)日：2010-08-05

申请号：PCT/EP2009003872

申请日：2009-05-29

申请人： UNIVERSITAETSKLINIKUM MUENSTER ,  KOENIG SIMONE ,  DREISEWERD KLAUS ,  PIRKL ALEXANDER

发明人： KOENIG SIMONE ,  DREISEWERD KLAUS ,  PIRKL ALEXANDER

IPC分类号： H01J49/04 ,  H01J49/16

CPC分类号： H01J49/168 ,  H01J49/0409 ,  H01J49/0463

摘要： The invention relates to an ion source means comprising at least one holding means for holding at least one sample to expose the sample to a mass spectrometer device, wherein the holding means comprises a structured sample support means for supporting the sample and/or a structured sample or sample comprising a structured surface, respectively.

摘要翻译： 本发明涉及一种离子源装置，其包括至少一个保持装置，用于保持至少一个样品以将样品暴露于质谱仪装置，其中保持装置包括用于支撑样品的结构化样品支撑装置和/或结构化样品 或分别包含结构化表面的样品。

公开(公告)号：WO2009124298A3

公开(公告)日：2010-03-18

申请号：PCT/US2009039563

申请日：2009-04-03

申请人： AGILENT TECHNOLOGIES INC ,  MORDEHAI ALEXANDER ,  WERLICH MARK H ,  LOVE CRAIG P ,  BERTSCH JAMES L

发明人： MORDEHAI ALEXANDER ,  WERLICH MARK H ,  LOVE CRAIG P ,  BERTSCH JAMES L

IPC分类号： H01J49/16

CPC分类号： H01J49/167

摘要： Improved apparatuses and methods are provided for ionizing samples and analyzing the samples with mass spectrometry. A liquid sample is electrosprayed into droplets out of the delivery end of a capillary. A conduit surrounds the capillary for transmitting a heated gas, the conduit being connected to a nozzle to release the heated gas into the ionization chamber, wherein the nozzle comprises at least one electrode to which a potential can be applied, which contributes to the generation of an electrical field at the delivery end of the capillary.

摘要翻译： 提供改进的装置和方法用于电离样品和质谱分析样品。 将液体样品从毛细管的输送端电喷雾成液滴。 管道围绕毛细管以传送加热气体，导管连接到喷嘴以将加热的气体释放到电离室中，其中喷嘴包括至少一个可以施加电位的电极，这有助于产生 在毛细管的输送端的电场。

公开(公告)号：WO2010013824A4

公开(公告)日：2010-02-04

申请号：PCT/JP2009/063709

申请日：2009-07-27

申请人： PANASONIC ELECTRIC WORKS CO., LTD. ,  URATANI, Yutaka ,  OBATA, Kenji ,  YANO, Takeshi ,  ISAKA, Atsushi

发明人： URATANI, Yutaka ,  OBATA, Kenji ,  YANO, Takeshi ,  ISAKA, Atsushi

IPC分类号： B05B5/10 ,  B60H3/02 ,  H02H7/00 ,  H01J49/16 ,  B05B5/057

摘要： An electrostatic atomizing (1) device includes an atomizing electrode (13) which generates charged fine water particles negatively charged in the form of mist, by generating an electric field when a high negative voltage is applied thereto in a state in which water is supplied; a water supply portion which supplies the water to the atomizing electrode; a discharge detection portion (5) which detects whether negative ion discharge, indicating discharge in which only negative ions are generated without generating the charged fine water particles, is occurring at the atomizing electrode or not; and a control portion (7) which reduces the electric field intensity of the electric field generated by the atomizing electrode when the discharge detection portion detects the occurrence of the negative ion discharge.

公开(公告)号：WO2009149124A1

公开(公告)日：2009-12-10

申请号：PCT/US2009/046026

申请日：2009-06-02

申请人： BIO-RAD LABORATORIES, INC. ,  PLOWS, Fiona ,  ROTH, Steven ,  RUSA, Mariana

发明人： PLOWS, Fiona ,  ROTH, Steven ,  RUSA, Mariana

IPC分类号： H01J49/00 ,  H01J49/16

CPC分类号： H01J49/164 ,  H01J49/0004 ,  Y10T436/24 ,  Y10T436/25375

摘要： The present invention provides methods for using detection methods, including mass spectrometry methods such as SELDI-TOF-MS, to detect and analyze molecules directly transferred from a sample to a surface to form a molecular print of the sample. Methods and compositions of the invention can be used to produce spatially and non-spatially oriented molecular prints for detection using methods such as mass spectrometry. Methods and compositions of the invention encompass molecular printing of tissues, cells and gels onto surfaces.

摘要翻译： 本发明提供了使用检测方法（包括SELDI-TOF-MS等质谱法）来检测和分析从样品直接转移到表面以形成样品的分子印迹的方法。 本发明的方法和组合物可以用于使用诸如质谱法的方法产生用于检测的空间和非空间取向的分子印迹。 本发明的方法和组合物包括组织，细胞和凝胶在表面上的分子印刷。

公开(公告)号：WO2009010379A3

公开(公告)日：2009-10-22

申请号：PCT/EP2008058232

申请日：2008-06-27

申请人： PROXEON BIOSYSTEMS AS ,  VORM OLE ,  GRAF THOMAS

发明人： VORM OLE ,  GRAF THOMAS

IPC分类号： H01J49/16

CPC分类号： H01J49/16 ,  H01J49/167

摘要： The present invention provides a novel nanospray emitter that includes a fluid inlet, an outlet orifice, and a passage for fluid: communication between the fluid inlet and outlet orifice. In one aspect of this embodiment, the passage facilitating fluid communication between the inlet and outlet elements is comprised of an outer capillary of a rigid material, such as nickel, that houses an inner capillary made from a highly conductive and inert material, such as gold; alternatively the inner material may constitute an inner coating of the outer capillary.

摘要翻译： 本发明提供了一种新颖的纳米喷雾发射器，其包括流体入口，出口孔和用于流体的通道：流体入口和出口孔之间的连通。 在该实施例的一个方面，促进入口和出口元件之间的流体连通的通道包括刚性材料（例如镍）的外部毛细管，其容纳由高导电性和惰性材料制成的内部毛细管，例如金 ; 或者，内部材料可以构成外部毛细管的内部涂层。

公开(公告)号：WO2008137484A3

公开(公告)日：2009-08-06

申请号：PCT/US2008062106

申请日：2008-04-30

申请人： THERMO FINNIGAN LLC ,  KOVTOUN VIATCHESLAV V

发明人： KOVTOUN VIATCHESLAV V

IPC分类号： H01J49/04 ,  H01J49/16

CPC分类号： H01J49/165 ,  H01J49/0463

摘要： An ion source is disclosed for forming multiply-charged analyte ions from a solid sample (110). A beam of pulsed radiation (12o) is directed onto a portion of the sample to desorb analyte molecules, A retaining structure (135) holding a solvent volume (130) is positioned proximate the sample. Desorbed analyte molecules contact a free surface (210) of the solvent and pass into solution. The solution is then conveyed through an outlet passageway (140) to an electrospray apparatus (145, 235), which introduces a spray of charged solvent droplets into an ionization chamber.

摘要翻译： 公开了用于从固体样品（110）形成多电荷分析物离子的离子源。 脉冲辐射束（12o）被引导到样品的一部分上以解吸分析物分子。保持溶剂体积（130）的保持结构（135）位于样品附近。 解吸的分析物分子与溶剂的自由表面（210）接触并进入溶液。 然后将溶液通过出口通道（140）输送到电喷雾装置（145,235），其将带电溶剂液滴的喷雾引入电离室。

公开(公告)号：WO2008082603B1

公开(公告)日：2008-10-02

申请号：PCT/US2007026411

申请日：2007-12-28

申请人： PURDUE RESEARCH FOUNDATION ,  VENTER ANDRE ,  COOKS ROBERT GRAHAM

发明人： VENTER ANDRE ,  COOKS ROBERT GRAHAM

IPC分类号： H01J49/16

CPC分类号： H01J49/165 ,  H01J49/142

摘要： An improvement to Desorption Electrospray Ionization (DESI), the process of creating ions directly from sample surfaces for mass spectrometric (MS) analysis by impinging a liquid spray onto the surface. The improvement is brought about by enclosing the spray and sample surface and MS-inlet capillary in a pressure tight enclosure. The invention includes methods of sampling a larger or smaller area of surface by impacting and collecting droplets from such an area. The invention allows DESI to be performed without need for careful control of the geometry of the sprayer and MS-inlet capillary positions and angles relative to the sample surface.

摘要翻译： 对脱附电喷雾电离（DESI）的改进，即直接从样品表面创建离子以进行质谱（MS）分析的过程，通过将液体喷雾撞击到表面上。 通过将喷雾和样品表面以及MS入口毛细管封闭在一个耐压外壳中来实现改进。 本发明包括通过从这样的区域冲击并收集液滴来取样更大或更小的表面区域的方法。 本发明允许进行DESI而不需要仔细控制喷雾器的几何形状和MS入口毛细管相对于样品表面的毛细管位置和角度。

公开(公告)号：WO2008103733A2

公开(公告)日：2008-08-28

申请号：PCT/US2008/054425

申请日：2008-02-20

申请人： APPLIED NANOTECH, INC. ,  SIONEX CORPORATION ,  NAZAROV, Erkinjon, G. ,  KRYLOV, Evgeny ,  MARKOSKI, Kenneth, A. ,  MILLER, Raanan, A. ,  FINK, Richard, Lee

发明人： NAZAROV, Erkinjon, G. ,  KRYLOV, Evgeny ,  MARKOSKI, Kenneth, A. ,  MILLER, Raanan, A. ,  FINK, Richard, Lee

IPC分类号： H01J27/26 ,  H01J49/16

CPC分类号： H01J27/26 ,  H01J49/147 ,  H01J2201/30434

摘要： Field emission based ionization sources are provided, with the emitter (305) being a carbon nanotube field emitter. Such emitters can replace Ni-63 beta emitters. Ionization of a gas (308) that is flowed through the gap (310) between the emitter plates (301, 302) is performed by electron capture of the flow of electrons by the molecules in the gas (308).

摘要翻译： 提供基于场发射的电离源，发射极（305）是碳纳米管场发射极。 这种发射器可以代替Ni-63 beta发射器。 通过气体（308）中的分子对电子流的电子捕获来执行流过发射极板（301,302）之间的间隙（310）的气体（308）的离子化。

公开(公告)号：WO2006124097A3

公开(公告)日：2008-03-20

申请号：PCT/US2006008023

申请日：2006-03-07

申请人： APPLERA CORP ,  MDS INC ,  HAYDEN KEVIN M ,  VESTAL MARVIN L ,  CAMPBELL JENNIFER M

发明人： HAYDEN KEVIN M ,  VESTAL MARVIN L ,  CAMPBELL JENNIFER M

IPC分类号： H01J49/16 ,  B01D59/44 ,  H01J49/00 ,  H01J49/40

CPC分类号： H01J49/164 ,  H01J49/004

摘要： The present teachings relate to MALDI-TOF instruments, instrument components, and methods of operation thereof. In various aspects, the MALDI-TOF instrument can serve and be operated as a MS/MS instrument. In various embodiments, provided are MALDI-TOF instruments, and methods of operating one or more components of a MALDI-TOF instrument, that facilitate one or more of increasing sensitivity, increasing resolution, increasing dynamic mass range, increasing sample support throughput, and decreasing operational downtime.

摘要翻译： 本教导涉及MALDI-TOF仪器，仪器部件及其操作方法。 在各个方面，MALDI-TOF仪器可以作为MS / MS仪器进行操作。 在各种实施方案中，提供了MALDI-TOF仪器，以及操作MALDI-TOF仪器的一个或多个组分的方法，其促进增加灵敏度，增加分辨率，增加动态质量范围，增加样品支持产量和降低 运行停机

公开(公告)号：WO2008022363A2

公开(公告)日：2008-02-28

申请号：PCT/AT2007/000396

申请日：2007-08-20

申请人： UNIVERSITÄT INNSBRUCK ,  BONN, Günther ,  HASHIR M.S., Muhammad, Ahsan ,  STECHER, Günther ,  BAKRY, Rania

发明人： BONN, Günther ,  HASHIR M.S., Muhammad, Ahsan ,  STECHER, Günther ,  BAKRY, Rania

IPC分类号： H01J49/16

CPC分类号： H01J49/0418

摘要： The invention relates to particles and monoliths for providing an ionized analyte for mass analysis by photon desorption having a size in the range of 0.5-100 μm, wherein said particles or monoliths are modified with a chemical compound capable of absorbing photons having a wave-length of at least 300 run. Said particles and monoliths allow the use of MALDI-MS for the high throughput screening of molecules having a molecular weight lower than 700 μ without interfering signals or with only a limited number of background signals.

摘要翻译： 本发明涉及用于提供用于通过光子解吸附进行质量分析的电离分析物的颗粒和单块，其尺寸范围为0.5-100μm，其中所述颗粒或单块被能够进行化学修饰的化合物 吸收波长至少为300nm的光子。 所述颗粒和单块允许使用MALDI-MS对分子量低于700μ的分子进行高通量筛选而不产生干扰信号或仅使用有限数量的背景信号。