公开(公告)号：WO2022243558A8

公开(公告)日：2022-11-24

申请号：PCT/EP2022/063824

申请日：2022-05-20

Applicant: AILEENS PHARMA S.R.L.

Inventor： DI MARCO, Roberto Maria Antonio ,  LONGO SORMANI, Sonia ,  VERGALITO, Franca ,  MAGNIFICO, Irene ,  PIETRANGELO, Laura ,  VENDITTI, Noemi ,  CUTULI, Marco Alfio ,  PETRONIO PETRONIO, Giulio

IPC: C12N1/20 ,  A61K31/726 ,  A61K35/74 ,  C12R1/01 ,  C12R2001/01

Abstract: The present invention relates to a bacterial cell wall or fragment thereof of a selected Gram-positive strain of Cutibacterium acnes linked with a mucopolysaccharide andto its uses in the prevention or treatment of an immunological disease especially ofskin or mucosae. A process for linking the bacterial cell wall of the selected Cutibacterium acnes to a mucopolysaccharide is also herein disclosed.

公开(公告)号：WO2021165434A1

公开(公告)日：2021-08-26

申请号：PCT/EP2021/054083

申请日：2021-02-18

Applicant: AILEENS PHARMA S.R.L.

Inventor： VERGALITO, Franca ,  LONGO SORMANI, Sonia ,  MAGNIFICO, Irene ,  PIETRANGELO, Laura ,  DI MARCO, Roberto Maria Antonio ,  CUTULI, Marco Alfio ,  VENDITTI, Noemi ,  PETRONIO PETRONIO, Giulio

IPC: C12R1/01 ,  A61K35/74 ,  C12N1/20

Abstract: The present invention relates to a selected bacterial strain of Cutibacterium acnes and/or a cell wall therefrom or a postbiotic of the strain and to medical or nutritional uses thereof. The invention also concerns with pharmaceutical or nutritional compositions containing the strain, cell wall or postbiotic therefrom for the prevention or treatment of inflammatory diseases such as dermatitis or psoriasis or infections, especially skin or mucosal fungal or bacterial infections.

公开(公告)号：WO2021111372A1

公开(公告)日：2021-06-10

申请号：PCT/IB2020/061477

申请日：2020-12-04

Applicant: SIFI S.P.A.

Inventor： SOLFATO, Elena ,  SUDANO ROCCARO, Andrea ,  ZAPPULLA, Cristina Maria Concetta ,  SPOTO, Carmela Giovanna ,  SPINA, Donato ,  PEPE, Veronica ,  SANTONOCITO, Manuela ,  PRICOCO, Angelo ,  VIOLA, Santa ,  CURATOLO, Maria Cristina ,  MAZZONE, Maria Grazia ,  DE PASQUALE, Giuseppe ,  GIULIANO, Francesco

IPC: A61K9/00 ,  A61K9/08 ,  A61K35/00 ,  A61K35/747 ,  A61K47/02 ,  A61K47/46

Abstract: The present invention relates to a sterile buffered eye topical composition containing metabolites of the fermentation of Lactobacillus pertaining to the species casei or paracasei and for ophthalmic use of the composition in the prevention or treatment of microbial eye infections, eye allergies, vernal keratoconjunctivitis and keratoconjunctivitis sicca and blepharitis.

公开(公告)号：WO2021099974A1

公开(公告)日：2021-05-27

申请号：PCT/IB2020/060884

申请日：2020-11-19

Applicant: GIULIANI S.P.A.

Inventor： GIULIANI, Giammaria ,  MARZANI, Barbara ,  MASCOLO, Antonio

IPC: A61K8/60 ,  A61K8/9789 ,  A61Q5/06

Abstract: The present invention relates to a cosmetic composition for the extemporaneous colouring of hair, comprising a colouring component of vegetable origin in combination with a dispersing component based on sucroester. The composition finds application in the extemporaneous colouring or semi-permanent dyeing of hair.

公开(公告)号：WO2021074913A1

公开(公告)日：2021-04-22

申请号：PCT/IB2020/059825

申请日：2020-10-19

Applicant: GHS - GEMELLI HEALTH SYSTEM S.R.L.

Inventor： MELE, Maria Cristina ,  RINNINELLA, Emanuele

IPC: A61K31/733 ,  A61K36/45 ,  A61K36/63 ,  A61P9/00 ,  A61P29/00 ,  A61P17/00

Abstract: A mixture (m) comprising or, alternatively, consisting of: (i) a Vaccinium macrocarpon fruit extract; (ii) a Vaccinium myrtillus fruit extract; (ill) a Ribes nigrum fruit extract; (iv) a Punica granatum extract; (v) an Aronia Melanocarpa fruit extract; (vi) a mixture of polyphenols extracted from leaves or fruits of Olea Europaea L.; (vii) inulin (fructose polymer) in particular for use in the treatment of a cardiovascular disease having an inflammatory component or origin.

公开(公告)号：WO2019224211A1

公开(公告)日：2019-11-28

申请号：PCT/EP2019/063143

申请日：2019-05-21

Applicant: GIULIANI S.P.A.

Inventor： GIULIANI, Giammaria ,  PAUS, Ralf ,  CHERET, Jérémy ,  MARZANI, Barbara ,  BARONI, Sergio

IPC: A61K31/045 ,  A61P17/10 ,  A61P17/00 ,  A61P17/06 ,  A61K9/00 ,  A61K47/10 ,  A61K9/08 ,  A61K9/107 ,  A61K8/34 ,  A61Q5/06 ,  A61Q19/00

Abstract: The present invention concerns the use of selected compounds in a cosmetic skin-care treatment or in the treatment of certain skin, scalp or mucosal diseases. The invention also provides a composition for topical use incorporating a pharmaceuti-cally or cosmetically effective amount of a compound for preventing or treating skin or mucosal diseases having an inflammatory component or for reducing the redness or irritation of skin or mucosae.

公开(公告)号：WO2019025548A1

公开(公告)日：2019-02-07

申请号：PCT/EP2018/071005

申请日：2018-08-02

Applicant: GIULIANI S.P.A.

Inventor： GIULIANI, Giammaria ,  PAUS, Ralf ,  GRIMALDI, Benedetto ,  MARZANI, Barbara ,  BARONI, Sergio

IPC: A61K36/53 ,  A61K31/4188 ,  A61K31/132 ,  A61P17/14 ,  A61K8/00

Abstract: The invention relates to a synergistic composition comprising a dry extract of plant of genus Galeopsis and a compound promoting autophagy selected from biotin and R-N1-spermidine or a salt thereof, wherein R is hydrogen or methyl and mixtures thereof. The synergistic compositions according to the invention may be in the form of a topical formulation or oral formulation and is useful as a promoter of autophagy especially in cells of human scalp hair follicles and in promoting hair growth and/or in the treatment of hair thinning or hair loss.

公开(公告)号：WO2018130282A1

公开(公告)日：2018-07-19

申请号：PCT/EP2017/050534

申请日：2017-01-12

Applicant: UNIVERSITA' DEGLI STUDI DI PADOVA

Inventor： CALICETI, Paolo ,  SALMASO, Stefano ,  MALFANTI, Alessio

IPC: C07H15/04 ,  A61K31/702 ,  A61K31/7032

Abstract: The present invention relates to (guanidyl)x-oligosaccharidic compounds having a star-like structure having the capacity of carrying and delivering drugs or biological molecules such as oligonucleotides, polypetides and proteins across biological membranes. The (guanidyl)x-oligosaccharidic compounds may form conjugates with functional moieties such as compounds having biological activity, fluorophores, radionuclides, macrosurfaces, targeting agents, and/or form complexes with anionic macromolecule such as ONs, peptides, proteins, nucleic acids, drugs, cell membranes.

公开(公告)号：WO2018114700A1

公开(公告)日：2018-06-28

申请号：PCT/EP2017/083087

申请日：2017-12-15

Applicant: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA ,  ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA ,  UNIVERSITA' DEGLI STUDI DI PADOVA

Inventor： DE VIVO, Marco ,  ORTEGA MARTINEZ, Jose Antonio ,  ARENCIBIA JIMENEZ, Jose Manuel ,  MINARINI, Anna ,  SISSI, Claudia

IPC: C07D401/04 ,  A61K31/517 ,  A61K31/519 ,  C07D471/04 ,  A61P35/00

Abstract: The present invention concerns 4-amino-2-pyrido-bicyclic pyrimidines as type II topoisomerase inhibitors and use thereof as medicaments especially in the treatment of cancer. The invention also provides a method for the manufacture of 4- amino-2-pyrido bicyclic pyrimidines.

公开(公告)号：WO2018055194A1

公开(公告)日：2018-03-29

申请号：PCT/EP2017/074337

申请日：2017-09-26

Applicant: NTC S.R.L.

Inventor： BUSETTI, Cesare ,  ZELASCHI, Daniela

IPC: A61K9/00 ,  A61K47/36 ,  A61K9/70 ,  A61K31/045 ,  A61K31/728 ,  A61K47/56

Abstract: The present invention concerns a complex of terpinen-4-ol with a polymer of cross-linked hyaluronic acid, in particular with urea, and compositions containing thereof. The invention further relates to the use of the complex, or compositions containing thereof, in the hygiene of the periocular area, and in the treatment of blepharitis, acne, rosacea, acute or chronic conjunctivitis or infestations caused by mites, in particular by Demodexor by Cheyletiella mite.

Abstract translation: 本发明涉及松油醇-4-醇与交联透明质酸的聚合物，特别是与尿素的复合物，以及含有其的组合物。 本发明进一步涉及该复合物或含有其的组合物在眼周区的卫生中的应用，以及治疗睑炎，痤疮，红斑痤疮，急性或慢性结膜炎或由螨引起的侵染，特别是通过 > Demodexor by Cheyletiella 。