公开(公告)号：WO2004020628A1

公开(公告)日：2004-03-11

申请号：PCT/GB2003/003773

申请日：2003-08-29

Applicant: UNIVERSITY OF DURHAM ,  DIXON, David, Peter ,  EDWARDS, Robert

Inventor： DIXON, David, Peter ,  EDWARDS, Robert

IPC: C12N15/10

CPC classification number: C12N9/1088 ,  C12N15/1027 ,  C12N15/8274

Abstract: Method for genetically engineering a plant-derived nucleic acid sequence encoding a protein with debilitating activity towards a toxin comprising in combination random gene shuffling followed by selective mutagenesis of one or more plant derived nucleic acid sequence(s).

Abstract translation: 用于将编码具有对毒素的衰弱活性的蛋白质的植物衍生的核酸序列进行遗传工程的方法，所述方法包括组合随机基因改组，随后选择性诱变一种或多种植物衍生的核酸序列。

公开(公告)号：WO2004017061A1

公开(公告)日：2004-02-26

申请号：PCT/GB2003/003591

申请日：2003-08-15

Applicant: UNIVERSITY OF YORK ,  GOODALL, David, Murray ,  BERGSTROM, Edmund, Thomas ,  ALLINSON, Nigel, Martin ,  MOON, Kevin, James

Inventor： GOODALL, David, Murray ,  BERGSTROM, Edmund, Thomas ,  ALLINSON, Nigel, Martin ,  MOON, Kevin, James

IPC: G01N27/447

CPC classification number: G01N21/0303 ,  G01N21/05 ,  G01N21/59 ,  G01N27/44721 ,  G01N30/466 ,  G01N30/74 ,  G01N2013/003 ,  G01N2021/0346

Abstract: An optical assembly comprising a light source, at least one sample vessel and a detector, the at least one vessel being positioned in a light path or paths created between the source and the detector in manner to enable transmission of light through the vessel wherein the light source is adapted to provide a beam of substantially collimated light, the detector comprises a plurality of detector locations and the vessel comprises a wall and core of relative shape and dimensions adapted to contain a sample for detection and to define at least two spatially separated transmitted light paths, a first wall path which enters and exits the vessel walls only, spatially separated from a second core path which enters and exits the vessel walls and additionally the vessel core, wherein the spatially separated wall and core paths are coupled to individual detector locations on the detector, a module or clip-on device therefor, method for detection and uses thereof.

Abstract translation: 一种光学组件，包括光源，至少一个样品容器和检测器，所述至少一个容器被定位在源于光源和检测器之间的光路或路径中，以便使光能透过容器，其中光 源适于提供基本上准直的光束，所述检测器包括多个检测器位置，并且所述容器包括相对形状和尺寸的壁和芯，其适于包含用于检测的样品并且限定至少两个空间分离的透射光 路径，仅进入和离开血管壁的第一壁路径，空间上与从血管壁进入和离开血管壁的第二核心路径隔开，另外还有血管核心，其中空间分离的壁和核心路径被联接到单独的检测器位置上 检测器，其模块或夹持装置，用于检测和使用的方法。

公开(公告)号：WO2004008125A1

公开(公告)日：2004-01-22

申请号：PCT/GB2003/003071

申请日：2003-07-14

Applicant: AOTI OPERATING COMPANY, INC. ,  HIGGS, Victor

Inventor： HIGGS, Victor

IPC: G01N21/95

CPC classification number: G01N21/94 ,  G01N21/6489 ,  G01N21/9501

Abstract: A method of quality control of cleaning processes for semiconductors such as silicon during device fabrication comprises taking an as-cleaned semiconductor structure following a critical cleaning process step; exposing the surface of the semiconductor structure to at least one high-intensity beam of light from a suitable light source, preferably a laser, and in particular a high-intensity laser, and collecting photoluminescence (PL) produced by excitation of the semiconductor structure by the light beam; making an analysis of the collected photoluminescence signal and using that analysis as the basis for a quality classification of the cleanliness of the semiconductor, in particular by: determining an average photoluminescence intensity emitted across the area of the structure; comparing the average with a predetermined acceptable specification range of photoluminescence; making a quality classification of the cleanliness of the semiconductor structure based thereon, and in particular rejecting or selecting for remedial action such as further cleaning semiconductor structures exhibiting a photoluminescence response outside the said predetermined acceptable specification range. In a preferred embodiment the method is applied as part of a quality control metric during device cleaning and processing. In a refinement of the method a spatially resolved PL map is also collected. An apparatus for performing the method is also described.

Abstract translation: 在器件制造过程中，诸如硅之类的半导体的清洁过程的质量控制方法包括在关键的清洁工艺步骤之后采取经清洁的半导体结构; 将半导体结构的表面暴露于来自合适的光源，优选激光器，特别是高强度激光器的至少一个高强度光束，以及收集由半导体结构激发产生的光致发光（PL） 光束; 对所收集的光致发光信号进行分析，并使用该分析作为半导体清洁度的质量分类的基础，特别是通过：确定在结构区域发射的平均光致发光强度; 将平均值与预定的可接受的光致发光规格范围进行比较; 对其进行基于其的半导体结构的清洁度的质量分类，特别是拒绝或选择补救动作，例如进一步清洁在所述预定可接受的规格范围之外表现出光致发光响应的半导体结构。 在优选实施例中，该方法作为设备清洁和处理期间的质量控制度量的一部分被应用。 在方法的改进中，还收集了空间解析的PL图。 还描述了一种用于执行该方法的装置。

公开(公告)号：WO2004004816A1

公开(公告)日：2004-01-15

申请号：PCT/GB2003/002473

申请日：2003-06-09

Applicant: KAPITEX HEALTHCARE LIMITED ,  WORTHINGTON, Ian, David

Inventor： WORTHINGTON, Ian, David

IPC: A61M16/04

CPC classification number: A61M16/0488 ,  A61M16/0465 ,  A61M16/0468 ,  A61M16/047

Abstract: A tracheostoma cannula mounting, a cannula assembly incorporating such a mounting, and a method of mounting the same within a stoma are described. The mounting includes a generally planar sheet portion (2) provided with an aperture (4) therein of suitable size and shape to engage a channel portion of a tracheostoma cannula (21) in interference fit so as to present a rearward mounting face (18) adapted in use to lie against the skin of the tracheostoma patient in the vicinity of the stoma. The material from which the sheet (2) is fabricated comprises tacky gel material such as silicone gel at least in the vicinity of the mounting face (18), and is preferably made essentially entirely from such material.

Abstract translation: 描述了气管插管安装件，并入这种安装件的套管组件以及将其安装在造口内的方法。 安装件包括大体上平坦的片部分（2），其中具有合适尺寸和形状的孔（4），以与过孔配合的气管插管（21）的通道部分接合，以呈现后方安装面（18） 适用于在造口附近躺在气管瘤患者的皮肤上。 制造片材（2）的材料至少在安装面（18）附近包括粘性凝胶材料如硅凝胶，并且优选基本上完全由这种材料制成。

公开(公告)号：WO2003104787A1

公开(公告)日：2003-12-18

申请号：PCT/GB2003/001902

申请日：2003-05-06

Applicant: UNIVERSITY OF DURHAM ,  KATAKY, Ritu ,  CAMERON, Neil, Ronald

Inventor： KATAKY, Ritu ,  CAMERON, Neil, Ronald

IPC: G01N27/30

CPC classification number: G01N27/333 ,  G01N27/48

Abstract: A sensor for electrochemically or optically determining a desired species, the sensor comprising at least one electrode or optical path, wherein the electrode or optical path is modified for specific accumulation of the desired species, by means of a modifying agent which is adapted to selectively and substantially reversibly bind the species to be detected and to release the species at a characteristic voltage or give an absorbance measurement at a characteristic optical wavelength, and wherein the modifying agent is associated with at least part of the surface of the electrode or optical path by physical or chemical anchoring. A method of fabricating and using such a sensor, particularly in harsh media such as whole blood and other body fluids, brackish water, industrial environments and the like.

Abstract translation: 一种用于电化学或光学地确定所需物种的传感器，所述传感器包括至少一个电极或光路，其中通过改性剂修饰所述电极或光路用于特定的所需物质的积累，所述改性剂适于选择性地和 基本上可逆地结合要检测的物质并以特征电压释放物种或在特征光学波长处产生吸光度测量，并且其中所述改性剂与所述电极或光学路径的表面的至少一部分通过物理 或化学锚定。 一种制造和使用这种传感器的方法，特别是在诸如全血和其它体液，微咸水，工业环境等的苛刻介质中。

公开(公告)号：WO2003102333A1

公开(公告)日：2003-12-11

申请号：PCT/GB2003/002371

申请日：2003-05-30

Applicant: EASYLOCK LIMITED ,  CLARK, Geoffrey

Inventor： CLARK, Geoffrey

IPC: E05B13/00

CPC classification number: E05B15/0053 ,  E05B13/004 ,  E05B63/0004

Abstract: A locking mechanism for a handle (4) for a door (1), window or the like is described. The locking mechanism consists of a generally flat bolt plate, optionally within a housing, adapted to be slidingly engaged generally parallel to a surface of the door and comprising a plate portion defining an aperture surrounding the spindle (3) of the handle in sue, wherein the aperture is so shaped that the bolt plate is slidable from a first position whereat in use the spindle is able to freely rotate within the aperture to a second position whereat in use the spindle is able to freely rotate within the aperture to a second position whereat in use the plate portion engages the spindle to restrict or prevent rotation thereof, and wherein a resilient bolt plate catch (2) is provided to selectively and releasably retain the bolt plate in the first or second position. A handle incorporating such a plate, and a method of fitment of such a plate into a handle, are also described.

Abstract translation: 描述了用于门（1）的手柄（4），窗口等的锁定机构。 所述锁定机构包括大致平坦的螺栓板，可选地在壳体内，适于大致平行于所述门的表面滑动地接合，并且包括限定围绕所述手柄的主轴（3）的孔的板部， 该孔是如此的形状，使得螺栓板可以从第一位置滑动，在第一位置，在使用中主轴能够在孔内自由旋转到第二位置，在第二位置，在使用中主轴能够在孔内自由旋转到第二位置， 在使用中，板部分接合主轴以限制或防止其旋转，并且其中提供弹性螺栓板挡块（2）以选择性地和可释放地将螺栓板保持在第一或第二位置。 还描述了包括这种板的手柄以及将这种板装配到手柄中的方法。

公开(公告)号：WO2003087802A3

公开(公告)日：2003-10-23

申请号：PCT/GB2003/001383

申请日：2003-03-28

Applicant: ELECTROCHEMICAL SENSOR TECHNOLOGY LIMITED ,  DOBSON, John, Vincent ,  MARSHALL, Robert, Neil

Inventor： DOBSON, John, Vincent ,  MARSHALL, Robert, Neil

IPC: G01N27/416

Abstract: A sensor system and method for measuring the concentration, or indicating the presence or presence at a predetermined level of, a target contaminant species in an aqueous medium are described. The system is based upon a sensor element (1) having a sample receiving area (2) for receiving a sample of aqueous medium to be sampled and which comprises at least three electrodes (5, 6, 7) each comprising a layer of conductor deposited upon an insulating substrate. The system also includes a power source (13) to apply a pre-determined potential difference across two of the electrodes determined by the potential associated with an electrochemical reaction characteristic of the target species, eg. Ammonia NH 3 , and output means (19) to output data corresponding to the current generated thereby when a sample is in place on the sampling area. In a preferred embodiment, differential pulsed square wave voltammetry is used.

公开(公告)号：WO2003078508A1

公开(公告)日：2003-09-25

申请号：PCT/GB2003/001015

申请日：2003-03-10

Applicant: UNIVERSITY OF NOTTINGHAM ,  HOWDLE, Steven, Melvyn ,  SHAKESHEFF, Kevin, Morris ,  WHITAKER, Martin, James ,  WATSON, Michael, Steven

Inventor： HOWDLE, Steven, Melvyn ,  SHAKESHEFF, Kevin, Morris ,  WHITAKER, Martin, James ,  WATSON, Michael, Steven

IPC: C08J3/20

CPC classification number: A61K9/0024 ,  A61K9/1647 ,  C08J3/203

Abstract: A process for the preparation of a polymer composite comprising internally distributed deposition matter wherein the process comprises providing a deposit of deposition matter at the surface of a solid state polymer substrate, contacting the surface deposited polymer with a plasticising fluid or a mixture of plasticising fluids under plasticising conditions to plasticise and/or swell the polymer and internally distribute deposition matter, and releasing the plasticising fluid or fluids to obtain polymer composite.; A polymer composite comprising a porous or non porous polymer throughout which particulate deposition matter as hereinbefore defined is distributed with desired uniformity, preferably with high uniformity in excess of 80 % for example in excess of 98 %.; A scaffold comprising a polymer composite having internally distributed deposition matter; and use of the composite as a support or scaffold for drug delivery, for use in bioremediation, as a biocatalyst or biobarrier for human or animal or plant matter, for use as a structural component, for example comprising the polymer and optional additional synthetic or natural metal, plastic, carbon or glass fibre mesh, scrim, rod or like reinforcing for medical or surgical insertion, for insertion as a solid monolith into bone or tissue, as fillers or cements for wet insertion into bone or teeth or as solid aggregates or monoliths for orthopaedic implants such as pins, or dental implants such as crowns etc.

Abstract translation: 一种用于制备包含内部分布的沉积物质的聚合物复合材料的方法，其中所述方法包括在固态聚合物基材的表面提供沉积物沉积物，使表面沉积聚合物与塑化流体或塑化流体的混合物接触， 增塑和/或溶胀聚合物并内部分散沉积物质，以及释放塑化流体或流体以获得聚合物复合材料的塑化条件; 包含多孔聚合物或非多孔聚合物的聚合物复合材料，其中如上文所定义的颗粒沉积物质以所需的均匀性分布，优选具有超过80％，例如超过98％的高均匀性。 一种支架，其包括具有内部分布的沉积物质的聚合物复合材料; 以及将复合材料用作药物递送的支持物或支架，用于生物修复，作为用于人或动物或植物物质的生物催化剂或生物保护剂，用作结构成分，例如包含聚合物和任选的其它合成或天然 用于医疗或手术插入的金属，塑料，碳或玻璃纤维网，稀松布，棒或类似的增强物作为固体整体作为骨或组织插入，作为用于湿插入骨或牙齿中的填料或水泥，或作为固体聚集体或整料 用于诸如针或诸如牙冠等牙科植入物的矫形植入物

公开(公告)号：WO2002077621A1

公开(公告)日：2002-10-03

申请号：PCT/GB2002/001197

申请日：2002-03-27

Applicant: AOTI OPERATING COMPANY, INC. ,  HIGGS, Victor

Inventor： HIGGS, Victor

IPC: G01N21/64

CPC classification number: G01N21/6489 ,  G01N21/55 ,  G01N21/9501

Abstract: A method and apparatus for the detection and classification of defects in a silicon or semi-conductor structure, in particular using room temperature photoluminescence effects, is described. The method involves directing a high intensity beam of light at a surface of a sample of silicon or semi-conductor structure to be tested producing a photoluminescence image, producing a reflected light image, combining the information in the two images to detect, map and identify and/or characterise micro-defects in the silicon or semi-conductor structure.

Abstract translation: 描述了用于检测和分类硅或半导体结构中的缺陷的方法和装置，特别是使用室温光致发光效应。 该方法包括在要测试的硅或半导体结构的样品的表面上引导高强度光束，产生光致发光图像，产生反射光图像，组合两个图像中的信息以检测，映射和识别 和/或表征硅或半导体结构中的微缺陷。

公开(公告)号：WO2009024794A1

公开(公告)日：2009-02-26

申请号：PCT/GB2008/002853

申请日：2008-08-22

Applicant: SMARTSENSOR TELEMED LIMITED ,  JACKSON, James

Inventor： JACKSON, James

IPC: A61B5/00 ,  A61B5/15

CPC classification number: A61B5/150358 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/1468 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150847 ,  A61B5/157 ,  A61B5/7275 ,  A61B2562/0295 ,  Y10T436/115831 ,  Y10T436/144444

Abstract: A glucose tolerance test device comprising: a test zone having a means to receive at least first and second blood test samples spaced apart by a predetermined time interval; a timer to measure such a time interval, and for example to measure elapsed time after collection of a said first sample; an indicator to indicate at least that a second test is due, operatively Jinked to the timer so as to make such indication after lapse of a predetermined time interval; a data collector to collect data from the lest zone in relation to each test sample; a data register to store data in relation to each test sample, in data commumczrtion with said data collector. A method of use is also described.

Abstract translation: 1.一种葡萄糖耐量测试装置，包括：测试区，具有至少接收第一和第二血液测试样本的装置，所述测试样本间隔开预定的时间间隔; 计时器，用于测量这样的时间间隔，并且例如测量收集所述第一样本之后的经过时间; 指示器至少指示第二测试到期，可操作地连接到定时器，以便在经过预定时间间隔之后进行这种指示; 数据收集器，用于从每个测试样本收集最小区域的数据; 数据寄存器，用于存储与每个测试样本有关的数据，与数据采集器进行数据通信。 还描述了使用方法。