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    CELLS FOR IMPROVED IMMUNOTHERAPY AND USES THEREOF
    73.
    发明申请
    CELLS FOR IMPROVED IMMUNOTHERAPY AND USES THEREOF 审中-公开

    公开(公告)号：WO2021021989A1

    公开(公告)日：2021-02-04

    申请号：PCT/US2020/044159

    申请日：2020-07-30

    Applicant: MEMORIAL SLOAN-KETTERING CANCER CENTER

    Inventor： SCHEINBERG, David, A. ,  PERARO, Leila

    IPC: A61K35/12 ,  A61K35/17 ,  A61K38/43 ,  A61K38/46 ,  C07K14/725 ,  C07K16/28

    Abstract: The presently disclosed subject matter provides cells and compositions for improved immunotherapy and methods of using such cells and compositions. It relates to cells comprising a ligand-recognizing receptor (e.g., an antigen-recognizing receptor, e.g., a chimeric antigen receptor (CAR) or a T-cell Receptor (TCR)) and an IgG-degrading enzyme or a fragment thereof. The IgG-degrading enzyme rapidly cleaves IgG. The IgG-degrading enzyme serves as a biomolecular shield against the host humoral response. The cells have increased resistance to host humoral response (e.g., an antibody-driven host humoral response), which allows for prolonged persistence of the cells, leading to enhanced activity of the cells.

    COMPOSITIONS AND METHODS OF USING MULTIPOTENT STEM CELLS TO REDUCE DISEASE AND ENHANCE WELLNESS
    74.
    发明申请
    COMPOSITIONS AND METHODS OF USING MULTIPOTENT STEM CELLS TO REDUCE DISEASE AND ENHANCE WELLNESS 审中-公开

    公开(公告)号：WO2021021919A1

    公开(公告)日：2021-02-04

    申请号：PCT/US2020/044050

    申请日：2020-07-29

    Applicant: RELEVANCE TOTAL HEALTH ,  WADE, Jill ,  CALILUNG, Xerxez

    Inventor： WADE, Jill ,  CALILUNG, Xerxez

    IPC: A01N1/02 ,  A61C5/00 ,  A61C8/00 ,  A61K35/12 ,  A61K35/32 ,  A61K6/00 ,  A61L27/38

    Abstract: Provided herein are methods of using multipotent stem cells in treatment or prophylaxis of disease, in a system for improving general health and overall wellness. The disclosure provides a method in which multipotent stem cells are intravenously administered within the oral cavity, which has a rapid effect on symptoms of inflammation and/or infection, not only treating periodontal diseases, but also reducing bacterial load, pain, bone loss, etc. as well as stimulating new bone growth and achieving other hallmarks of improvement in health and overall systemic wellness. In some instances, a sample of a bodily fluid is drawn from the patient before injection to measure baseline levels of several biomarkers to obtain the patient's status on the spectrum of health and wellness and/or to compare post-treatment effects of the injected stem cells, to measure improvement, and to develop a treatment plan for enhancing multisystem wellness.

    一种基于线粒体的药物递送系统及其用途
    77.
    发明申请
    一种基于线粒体的药物递送系统及其用途 审中-公开

    公开(公告)号：WO2021004477A1

    公开(公告)日：2021-01-14

    申请号：PCT/CN2020/100825

    申请日：2020-07-08

    Applicant: 唐凌峰 ,  吴忆华

    Inventor： 唐凌峰 ,  吴忆华

    IPC: A61K35/12 ,  A61P25/00 ,  A61P35/00 ,  A61P9/00

    Abstract: 一种基于线粒体的药物递送系统，所述药物递送系统包括：线粒体，和负载于所述线粒体的药物，其中所述药物是通过非自由扩散的方式负载于所述线粒体的。该药物递送系统能够有效地将蛋白质类、核酸类或其他药物递送到细胞内，能够用于治疗单基因遗传病、多基因遗传病或其他疾病，也可用于健康个体以实现延缓衰老、增强机体功能或者预防疾病等目的。

    肝祖细胞样细胞库的构建方法及其制备的细胞株与应用
    78.
    发明申请
    肝祖细胞样细胞库的构建方法及其制备的细胞株与应用 审中-公开

    公开(公告)号：WO2021004129A1

    公开(公告)日：2021-01-14

    申请号：PCT/CN2020/086659

    申请日：2020-04-24

    Applicant: 上海赛立维生物科技有限公司

    Inventor： 鄢和新

    IPC: C12N5/22 ,  C12N5/071 ,  A61K35/12 ,  A61K35/407

    Abstract: 提供了一种肝祖细胞样细胞库的构建方法，包括：对不同供体来源的人原代肝细胞培养物依次进行转化培养、冻存处理、增殖培养、第一传代处理、病毒感染、第二传代处理、连续筛选培养以及连续传代培养。所述异质性永生肝祖细胞样细胞库构建方法中，对每个供体来源的人原代肝细胞培养物在进行所述增殖培养前先进行转化培养，有利于赋予所述人原代肝细胞培养物良好的增殖性能，结合后续的培养参数控制，使得到的不同供体来源的永生肝祖细胞样细胞株具有良好的体外增殖能力。还提供了所述肝祖细胞样细胞库的应用以及通过所述构建方法得到的细胞株。

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