公开(公告)号：WO2019246563A1

公开(公告)日：2019-12-26

申请号：PCT/US2019/038547

申请日：2019-06-21

Applicant: KITE PHARMA, INC.

Inventor： EMTAGE, Peter ,  ROMAIN, Gabrielle ,  VINCENT, Rosa ,  WYMAN, Sarah

IPC: C07K14/715 ,  C12N15/62 ,  C07K14/54

Abstract: Provided herein are chimeric transmembrane proteins comprising a transmembrane domain of an alpha chain of interleukin-7 receptor with one or more modifications. Also provided herein are nucleic acids encoding these chimeric transmembrane proteins, and mammalian cells containing these nucleic acids, and methods of making and using these mammalian cells.

公开(公告)号：WO2019183389A1

公开(公告)日：2019-09-26

申请号：PCT/US2019/023424

申请日：2019-03-21

Applicant: KITE PHARMA, INC.

Inventor： EMTAGE, Peter ,  VINCENT, Rosa

IPC: C07K14/55 ,  C07K14/715

Abstract: Provided herein are chimeric transmembrane proteins, nucleic acids encoding these chimeric transmembrane proteins, and mammalian cells containing these nucleic acids, and methods of making and using these mammalian cells.

公开(公告)号：WO2020257823A2

公开(公告)日：2020-12-24

申请号：PCT/US2020/070157

申请日：2020-06-19

Applicant: KITE PHARMA, INC.

Inventor： WYMAN, Sarah ,  EMTAGE, Peter ,  ROMAIN, Gabrielle

IPC: C07K14/725 ,  C07K14/495 ,  A61K38/18 ,  A61K35/12

Abstract: Provided herein are engineered receptors involved in cytokine signaling. Also provided herein are engineered receptors for modulating TGF-β signaling, methods of modulating TGF-β signaling and treating cancer using chimeric antigen receptors.

公开(公告)号：WO2022036041A1

公开(公告)日：2022-02-17

申请号：PCT/US2021/045668

申请日：2021-08-12

Applicant: KITE PHARMA, INC

Inventor： EMTAGE, Peter ,  FENG, Jun ,  NOWYHED, Heba ,  PHUNG, Tammy

IPC: A61K39/00 ,  C12N5/0783 ,  C12N5/10 ,  C07K14/715 ,  C07K19/00 ,  A61P35/00

Abstract: The present disclosure relates to the field of cell therapy, and more specifically, to improving CAR and/or TCR function through improvement of the tumor microenvironment via improvement in cytokine signaling.