公开(公告)号：WO2006105403A3

公开(公告)日：2006-10-05

申请号：PCT/US2006/011930

申请日：2006-03-30

Applicant: SIRTRIS PHARMACEUTICALS, INC. ,  WESTPHAL, Christopher, R. ,  DIPP, Michelle ,  MILBURN, Michael

Inventor： WESTPHAL, Christopher, R. ,  DIPP, Michelle ,  MILBURN, Michael

IPC: A61K31/05 ,  A61K31/353 ,  A61K31/56 ,  A61P27/06

Abstract: Sirtuin modulators, particularly sirtuin activators, are useful in treating vision impairment. In general, the sirtuin modulators inhibit the progression of vision impairment resulting from various eye disorders. The invention also includes pharmaceutically acceptable formulations of sirtuin modulators, particular ophthalmically acceptable formulations.

公开(公告)号：WO2006105403A2

公开(公告)日：2006-10-05

申请号：PCT/US2006011930

申请日：2006-03-30

Applicant: SIRTRIS PHARMACEUTICALS INC ,  WESTPHAL CHRISTOPHER R ,  DIPP MICHELLE ,  MILBURN MICHAEL

Inventor： WESTPHAL CHRISTOPHER R ,  DIPP MICHELLE ,  MILBURN MICHAEL

CPC classification number: A61K31/05 ,  A61K31/353 ,  A61K31/56

Abstract: Sirtuin modulators, particularly sirtuin activators, are useful in treating vision impairment. In general, the sirtuin modulators inhibit the progression of vision impairment resulting from various eye disorders. The invention also includes pharmaceutically acceptable formulations of sirtuin modulators, particular ophthalmically acceptable formulations.

Abstract translation: Sirtuin调节剂，特别是sirtuin激活剂，可用于治疗视力障碍。 通常，沉默调节蛋白调节剂抑制由各种眼睛疾病引起的视力障碍的进展。 本发明还包括Sirtuin调节剂的药学上可接受的制剂，特别是眼用可接受的制剂。

公开(公告)号：WO2006094237A2

公开(公告)日：2006-09-08

申请号：PCT/US2006007746

申请日：2006-03-03

Applicant: SIRTRIS PHARMACEUTICALS INC ,  MILBURN MICHAEL ,  MILNE JILL ,  BEMIS JEAN ,  NUNES JOSEPH J ,  XIE ROGER ,  NORMINGTON KARL D

Inventor： MILBURN MICHAEL ,  MILNE JILL ,  BEMIS JEAN ,  NUNES JOSEPH J ,  XIE ROGER ,  NORMINGTON KARL D

IPC: C07D401/12 ,  C07D215/48 ,  C07D215/52 ,  C07D219/04 ,  C07D219/10 ,  C07D405/12 ,  C07D413/04

CPC classification number: C07D401/14 ,  C07D215/48 ,  C07D215/52 ,  C07D219/04 ,  C07D219/10 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, chemo therapeutic induced neuropathy, neuropathy associated with an ischemic event, polyglutamine diseases, ocular diseases and/or disorders, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

Abstract translation: 本文提供了新的沉默调节蛋白的调节化合物及其使用方法。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 化学治疗性诱导的神经病变，与缺血事件相关的神经病变，多聚谷氨酰胺病，眼部疾病和/或病症，心血管疾病，凝血障碍，炎症，癌症和/或潮红。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。

公开(公告)号：WO2006094210A2

公开(公告)日：2006-09-08

申请号：PCT/US2006/007656

申请日：2006-03-03

Applicant: SIRTRIS PHARMACEUTICALS, INC. ,  MILNE, Jill ,  NORMINGTON, Karl, D. ,  MILBURN, Michael

Inventor： MILNE, Jill ,  NORMINGTON, Karl, D. ,  MILBURN, Michael

CPC classification number: C07D487/04 ,  C07D413/12 ,  C07D413/14

Abstract: Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

Abstract translation: 本文提供了新的沉默调节蛋白的调节化合物及其使用方法。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，凝血障碍，炎症，癌症和/或潮红以及由线粒体活性增加所致的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。

公开(公告)号：WO2006094209A2

公开(公告)日：2006-09-08

申请号：PCT/US2006/007655

申请日：2006-03-03

Applicant: SIRTRIS PHARMACEUTICALS, INC. ,  MILBURN, Michael ,  MILNE, Jill ,  NORMINGTON, Karl, D.

Inventor： MILBURN, Michael ,  MILNE, Jill ,  NORMINGTON, Karl, D.

CPC classification number: C07D401/06 ,  C07D235/24 ,  C07D235/28

Abstract: Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

Abstract translation: 本文提供了新的沉默调节蛋白的调节化合物及其使用方法。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，凝血障碍，炎症，癌症和/或潮红以及由线粒体活性增加所致的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。