公开(公告)号：WO2023091554A1

公开(公告)日：2023-05-25

申请号：PCT/US2022/050221

申请日：2022-11-17

Applicant: ICAGEN, LLC ,  F. HOFFMANN-LA ROCHE AG ,  HOFFMANN-LA ROCHE INC.

Inventor： LEBRETON, Sylvain ,  GERLACH, Aaron ,  REDONDO, Roger ,  NORCROSS, Roger, David ,  MA, Nina ,  LI, Ronghua ,  MOWERY, David ,  NAIR, Anil ,  MECHIN, Ingrid ,  SAFAROVA, Alena ,  SMRCINA, Martin ,  DAVIDSON, James ,  GRAHAM, Christopher, John ,  NAGARAJAN, Karthigeyan ,  CHAPMAN, Mark ,  DAVIES, Nicholas, Gareth Morse

IPC: C07D213/36 ,  C07D213/56 ,  C07D213/64 ,  C07D213/84 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/04 ,  C07D493/08 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28

Abstract: The invention provides new heteroaromatic compounds having the general formula (I'), or a solvate or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, Y1, Y2, Y3, and n are as defined herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：WO2023072026A1

公开(公告)日：2023-05-04

申请号：PCT/CN2022/127233

申请日：2022-10-25

Applicant: SIRONAX LTD. ,  ZHANG, Zhiyuan

Inventor： ZHANG, Zhaolan ,  SUN, Weidong ,  XU, Yanping ,  JIANG, Yimin ,  LIU, Lianzhu

IPC: C07D213/16 ,  C07D403/04 ,  C07D413/04 ,  A61K31/44 ,  A61K31/4427 ,  A61P25/14 ,  A61P25/16

Abstract: Provided herein are compounds of Formula (I), compositions comprising the same, and methods of using the same, including use in treating various diseases and conditions, e.g., those caused by axonal degeneration.

公开(公告)号：WO2023043836A1

公开(公告)日：2023-03-23

申请号：PCT/US2022/043527

申请日：2022-09-14

Applicant: METACRINE, INC.

Inventor： NAGASAWA, Johnny Y. ,  BOTROUS, Iriny ,  LAI, Andiliy G. ,  HUDSON, Andrew R. ,  SMITH, Nicholas D. ,  GOVEK, Steven P.

IPC: C07D401/10 ,  C07D403/04 ,  C07D403/10 ,  C07D413/04 ,  C07D413/10 ,  C07D471/04 ,  C07D487/04 ,  C07D401/14 ,  A61K31/4192 ,  A61K31/444 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61P1/16

Abstract: Described herein are compounds that are HSD17B13 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with HSD17B13 activity.

公开(公告)号：WO2023041756A1

公开(公告)日：2023-03-23

申请号：PCT/EP2022/075878

申请日：2022-09-19

Applicant: F. HOFFMANN-LA ROCHE AG ,  HOFFMANN-LA ROCHE INC.

Inventor： ANDREOTTI, Daniele ,  CUMMING, John G. ,  FOSSATI, Giacomo ,  SAMPAOLESI, Susanna ,  SERRA, Elena

IPC: C07D413/04 ,  C07D413/14 ,  C07D498/04 ,  C07D513/04 ,  A61P31/04

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3a, R3b, R4, A1, A2, A3, A4, A5, A6, B1, B2, B3, B4, and L are as described herein, compositions including the compounds and methods of using the compounds.

公开(公告)号：WO2023016530A1

公开(公告)日：2023-02-16

申请号：PCT/CN2022/111904

申请日：2022-08-11

Applicant: 南京明德新药研发有限公司

Inventor： 吴凌云 ,  赵乐乐 ,  孙建军 ,  黎健 ,  陈曙辉

IPC: C07D413/04 ,  A61K31/538 ,  A61P35/00

Abstract: 公开了一类3,4-二氢-2H-苯并[b][1,4]噁嗪类化合物及其制备方法，以及该类化合物在制备治疗相关疾病药物中的应用。具体公开了式(Ⅰ)所示化合物及其药学上可接受的盐。

公开(公告)号：WO2023001028A1

公开(公告)日：2023-01-26

申请号：PCT/CN2022/105236

申请日：2022-07-12

Applicant: 南京明德新药研发有限公司

Inventor： 雷茂义 ,  徐雨 ,  罗云富 ,  陈曙辉

IPC: C07D413/04 ,  C07D491/00 ,  C07D405/04 ,  C07D493/00 ,  C07D307/79 ,  C07D401/04 ,  A61K31/421 ,  A61K31/445 ,  A61P35/00

Abstract: 一种杂芳-3-哌啶二酮类化合物及其应用，具体公开了式(II)所示化合物及其药学上可接受的盐。

公开(公告)号：WO2023284782A1

公开(公告)日：2023-01-19

申请号：PCT/CN2022/105437

申请日：2022-07-13

Applicant: 复旦大学

Inventor： 鲁伯埙 ,  费义艳 ,  丁澦 ,  党永军

IPC: G01N33/68 ,  A61K31/404 ,  A61K31/4178 ,  A61P25/28 ,  A61P25/14 ,  C07J71/00 ,  C07D209/12 ,  C07D413/04 ,  C07D401/04

Abstract: 一种筛选用于治疗或预防mHTT相关的神经退行性疾病的化合物的方法，用于筛选的靶蛋白，以及相应的化合物。

公开(公告)号：WO2022236253A1

公开(公告)日：2022-11-10

申请号：PCT/US2022/072058

申请日：2022-05-02

Applicant: NUVATION BIO INC.

Inventor： PHAM, Son Minh ,  KANKANALA, Jayakanth ,  PETTIGREW, Jeremy D. ,  MILLER, Chris P. ,  PUJALA, Brahmam ,  BHATT, Bhawana ,  KUMAR, Varun ,  NAYAK, Anjan Kumar ,  SHETE, Amit Shivraj ,  SONI, Sanjeev

IPC: C07D413/04 ,  A61K31/4164 ,  A61K31/421 ,  A61K31/425 ,  A61K31/42 ,  C07D413/14 ,  A61K31/426 ,  A61P35/00

Abstract: Heterocyclic compounds as CDK4 or CDK6 or other CDK inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

公开(公告)号：WO2022235575A1

公开(公告)日：2022-11-10

申请号：PCT/US2022/027306

申请日：2022-05-02

Applicant: PETRA PHARMA CORPORATION

Inventor： ANDERSON, Erin Danielle ,  ARONOW, Sean Douglas ,  BOYLES, Nicholas A. ,  CHEN, Xiaohong ,  DAWADI, Surendra ,  HICKEY, Eugene R. ,  IRVIN, Thomas Combs ,  KESICKI, Edward A. ,  KNIGHT, Jennifer Lynn ,  KOLAKOWSKI, Gabrielle R. ,  KUMAR, Manoj ,  LONG, Katelyn Frances ,  MAYNE, Christopher Glenn ,  PICADO, Alfredo ,  POTOTSCHNIG, Gerit Maria ,  WANG, Hua-Yu ,  WELCH, Michael Brian ,  WIDJAJA, Tien ,  WRIGHT, Nathan Edward

IPC: C07D417/04 ,  C07D413/04 ,  C07D405/04 ,  C07D405/14 ,  A61P35/00 ,  A61K31/4433 ,  A61K31/506 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4192 ,  A61K31/4245

Abstract: The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3‑kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I) or pharmaceutically acceptable salts thereof wherein R, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof.

公开(公告)号：WO2022234470A1

公开(公告)日：2022-11-10

申请号：PCT/IB2022/054107

申请日：2022-05-04

Applicant: PI INDUSTRIES LTD.

Inventor： BHUJADE, Paras Raybhan ,  NAIK, Maruti N ,  SWARNKAR, Sonali ,  KORE, Nitin Shivanna ,  AUTKAR, Santosh Shridhar ,  KLAUSENER, Alexander G.M.

IPC: C07D413/04 ,  C07D413/14 ,  C07D495/04 ,  A01N43/82 ,  A01N43/90

Abstract: The present invention relates to compounds of formula (I), Formula (I) wherein, R1, R2, Z1, Z2 and m are as defined in the detailed description, and a process for preparing such compounds of formula (I). The present invention also relates to the use of compounds of formula (I) for combating phytopathogenic fungi and to a method for combating phytopathogenic fungi.