公开(公告)号：WO01068707A1

公开(公告)日：2001-09-20

申请号：PCT/US2001/006301

申请日：2001-02-27

IPC: A61P35/00 ,  C07K14/81 ,  C12N15/15 ,  A61K38/57 ,  A61K39/395 ,  C07K16/38 ,  C12N5/10 ,  C12N15/62

CPC classification number: C07K14/8114 ,  C07K2319/00 ,  C12N2799/026

Abstract: The present invention provides nucleic acid sequences encoding novel human hepatocyte growth factor activator inhibitors (HGF-AIh). These novel nucleic acids are useful for constructing the claimed DNA vectors and host cells of the invention and for preparing the claimed recombinant proteins and antibodies.

Abstract translation: 本发明提供编码新型人肝细胞生长因子激活抑制剂（HGF-AIh）的核酸序列。 这些新型核酸可用于构建所要求保护的本发明的DNA载体和宿主细胞并用于制备要求保护的重组蛋白和抗体。

公开(公告)号：WO01046421A2

公开(公告)日：2001-06-28

申请号：PCT/US2000/034571

申请日：2000-12-18

IPC: A61K38/00 ,  C07K14/81 ,  C12N15/15 ,  A61K38/57 ,  C07K16/38 ,  C07K16/42 ,  C12Q1/68 ,  G01N33/577

CPC classification number: C07K14/8139 ,  A61K38/00

Abstract: The cystatin superfamily are inhibitors of cysteine proteinases, which function in a protective role with regard to various pathological actions of endogenous proteinases. Zcys5 is a new member of this superfamily.

Abstract translation: 半胱氨酸蛋白酶抑制剂超家族是半胱氨酸蛋白酶的抑制剂，其在内源性蛋白酶的各种病理作用方面具有保护作用。 Zcys5是这个超家族的新成员。

公开(公告)号：WO00078963A1

公开(公告)日：2000-12-28

申请号：PCT/EP1999/004331

申请日：1999-06-22

IPC: A61K38/00 ,  A61K48/00 ,  C07K14/81 ,  C07K16/38 ,  C12N15/15 ,  A61K31/70 ,  A61K38/57 ,  A61K39/395 ,  C12N15/11 ,  G01N33/68

CPC classification number: C07K16/38 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/811

Abstract: The invention relates to serin proteinase inhibitors having the amino acid sequence in accordance with Seq. ID Nr. 1.

Abstract translation: 丝氨酸蛋白酶抑制剂按照氨基酸序列SEQ。 ID NO。1 ,.

公开(公告)号：WO00031264A2

公开(公告)日：2000-06-02

申请号：PCT/US1999/025519

申请日：1999-11-01

IPC: A61K38/00 ,  C07K14/81 ,  C12N15/15 ,  C07K16/38

CPC classification number: C07K14/8139 ,  A61K38/00 ,  C07K2319/00

Abstract: The present invention relates to cystatin T (also known as zcys3) polypeptides and polynucleotides encoding the same. Cystatin T polypeptide is testis specific and homologous to cystatin-related epididymal specific gene (CRES) and type 2 cystatins. The polypeptides would be useful for modulating spermatogenesis and may be used to study or modulate that function in in vitro or in vivo systems. The present invention also includes antibodies to the cystatin T polypeptides.

Abstract translation: 本发明涉及半胱氨酸蛋白酶抑制剂T多肽（称为zcys3）和编码它们的多核苷酸。 半胱氨酸蛋白酶抑制剂多肽T分别专用于睾丸和附睾的对应相关半胱氨酸蛋白酶抑制剂基因特异性（CRES）和半胱氨酸蛋白酶抑制剂的2型多肽可用于调节精子发生有用和可被用于在系统研究或调节该功能 在体外和体内。 根据本发明，抗体也被掺入半胱氨酸蛋白酶抑制剂T多肽中。

公开(公告)号：WO00018436A1

公开(公告)日：2000-04-06

申请号：PCT/EP1999/007405

申请日：1999-09-24

IPC: A61K45/00 ,  A61K38/00 ,  A61K38/48 ,  A61K39/395 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  C07K16/38

CPC classification number: A61K38/484 ,  C07K16/38

Abstract: The present invention relates to a new means for the treatment of focal ischemic cerebral infarction (ischemic stroke). It has been found that reduction of alpha 2-antiplasmin leads to a significantly smaller focal cerebral infarct size. The invention therefore provides the use of compounds that reduce alpha 2-antiplasmin concentration or activity in vivo, for the preparation of a therapeutical composition for the treatment of focal cerebral ischemic infarction (ischemic stroke).

Abstract translation: 本发明涉及一种治疗局灶性脑缺血性脑梗死（缺血性卒中）的新手段。 已经发现，减少α2-抗血浆素导致明显较小的局灶性脑梗死面积。 因此，本发明提供了在制备用于治疗局灶性脑缺血性梗塞（缺血性中风）的治疗组合物中降低α2-抗血浆素浓度或体内活性的化合物的用途。

公开(公告)号：WO00014235A1

公开(公告)日：2000-03-16

申请号：PCT/US1999/020202

申请日：1999-09-01

IPC: C12N15/09 ,  A61K38/00 ,  A61K48/00 ,  A61P1/00 ,  A61P1/16 ,  A61P1/18 ,  A61P7/00 ,  A61P7/02 ,  A61P9/10 ,  A61P11/00 ,  A61P13/02 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  A61P31/04 ,  A61P43/00 ,  C07K14/81 ,  C07K16/38 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/99 ,  C12N15/15 ,  C12P21/02

CPC classification number: C07K14/8114 ,  A61K38/00 ,  A61K48/00

Abstract: Proteinase inhibitors comprising a Kunitz domain are disclosed. The Kunitz domain comprises a sequence of amino acid residues as shown in SEQ ID NO:3, wherein the sequence is at least 80 % identical to residues 6 through 56 of SEQ ID NO:2. Also disclosed are methods for making the proteinase inhibitors, and expression vectors and cultured cells that are useful within the methods. The proteinase inhibitors may be used as components of cell culture media, in protein purification, and in certain therapeutic and diagnostic applications.

Abstract translation: 公开了包含Kunitz结构域的蛋白酶抑制剂。 Kunitz结构域包含如SEQ ID NO：3所示的氨基酸残基序列，其中该序列与SEQ ID NO：2的残基6至56至少80％相同。 还公开了制备蛋白酶抑制剂，表达载体和在该方法中有用的培养细胞的方法。 蛋白酶抑制剂可用作细胞培养基的组分，蛋白质纯化以及某些治疗和诊断应用。

公开(公告)号：WO99057274A1

公开(公告)日：1999-11-11

申请号：PCT/US1999/009190

申请日：1999-04-28

IPC: C12N15/09 ,  A61K38/00 ,  A61K45/00 ,  A61P19/02 ,  A61P35/00 ,  A61P37/02 ,  C07K14/81 ,  C07K16/38 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/48 ,  C12N9/64 ,  C12N15/15 ,  C12N15/57 ,  C12P21/02 ,  C12Q1/68 ,  A61K38/55 ,  C12N15/63

CPC classification number: C07K14/8114 ,  A61K38/00 ,  C12N9/48 ,  C12N9/6421

Abstract: The invention provides human protease associated proteins (HPRAP) and polynucleotides which identify and encode HPRAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HPRAP.

Abstract translation: 本发明提供了人类蛋白酶相关蛋白（HPRAP）和识别和编码HPRAP的多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与HPRAP表达相关的障碍的方法。

公开(公告)号：WO9919363B1

公开(公告)日：1999-07-15

申请号：PCT/US9821900

申请日：1998-10-16

Applicant: BIOWHITAKER TECHNOLOGIES ,  HERBSTRITT CHRISTOPHER J ,  PEPE MICHAEL G

Inventor： HERBSTRITT CHRISTOPHER J ,  PEPE MICHAEL G

IPC: G01N33/577 ,  C07K1/22 ,  C07K16/18 ,  C07K16/38 ,  C07K17/00 ,  C12N5/10 ,  C12N5/20 ,  C12N15/02 ,  G01N33/53 ,  G01N33/579

CPC classification number: C07K16/18 ,  G01N33/5308 ,  Y10S435/975

Abstract: The present invention is directed to monoclonal antibodies which specifically bind to a Limulus alpha 2-macroglobulin. Preferred monoclonal antibodies inhibit the enzymatic activation of a Limulus amebocyte lysate to form a gel or to cleave a chromogenic substrate in the presence of an endotoxin but not in the presence of a glucan. The monoclonal antibodies can be used, inter alia, to purify a Limulus alpha 2-macroglobulin, and the preferred antibodies can be used in a method for specifically detecting a glucan in a test sample using an amebocyte lysate.

Abstract translation: 本发明涉及特异性结合Limα2-巨球蛋白的单克隆抗体。 优选的单克隆抗体在内毒素存在下但不在葡聚糖存在下抑制Lim变形细胞裂解物的酶促活化形成凝胶或裂解生色底物。 单克隆抗体尤其可用于纯化Limα2-巨球蛋白，并且优选的抗体可用于使用变形细胞裂解物特异性检测测试样品中的葡聚糖的方法中。

公开(公告)号：WO99019363A1

公开(公告)日：1999-04-22

申请号：PCT/US1998/021900

申请日：1998-10-16

IPC: G01N33/577 ,  C07K1/22 ,  C07K16/18 ,  C07K16/38 ,  C07K17/00 ,  C12N5/10 ,  C12N5/20 ,  C12N15/02 ,  G01N33/53 ,  G01N33/579

CPC classification number: C07K16/18 ,  G01N33/5308 ,  Y10S435/975

Abstract: The present invention is directed to monoclonal antibodies which specifically bind to a Limulus alpha 2-macroglobulin. Preferred monoclonal antibodies inhibit the enzymatic activation of a Limulus amebocyte lysate to form a gel or to cleave a chromogenic substrate in the presence of an endotoxin but not in the presence of a glucan. The monoclonal antibodies can be used, inter alia, to purify a Limulus alpha 2-macroglobulin, and the preferred antibodies can be used in a method for specifically detecting a glucan in a test sample using an amebocyte lysate.

Abstract translation: 本发明涉及特异性结合鲎α-2-巨球蛋白的单克隆抗体。 优选的单克隆抗体抑制鲎变形细胞溶解产物的酶活化以形成凝胶或在存在内毒素但不在葡聚糖存在下切割显色底物。 单克隆抗体尤其可以用于纯化鲎α2-巨球蛋白，并且优选的抗体可用于使用微血管细胞裂解物特异性检测测试样品中的葡聚糖的方法。

公开(公告)号：WO98031797A1

公开(公告)日：1998-07-23

申请号：PCT/US1998/000678

申请日：1998-01-15

IPC: A61K38/00 ,  C07K14/705 ,  C12N15/12 ,  C07K16/38 ,  C12N5/10 ,  G01N33/68

CPC classification number: C07K14/70567 ,  A61K38/00

Abstract: Novel human nuclear hormone receptor polynucleotides and polypeptides, and related compositions and methods are disclosed. The polypeptides and polynucleotides have nuclear hormone receptor characteristics and homology to other mammalian nuclear hormone receptors. The receptor polypeptides may be used within methods to detect the natural human ligand and ligand analogs. The receptor polypeptides can also be used within methods to influence biological functions and maintenance of homeostasis.

Abstract translation: 公开了新的人核激素受体多核苷酸和多肽，以及相关的组合物和方法。 多肽和多核苷酸具有核激素受体特征和与其它哺乳动物核激素受体的同源性。 受体多肽可用于检测天然人配体和配体类似物的方法中。 受体多肽也可用于影响生物功能和维持体内平衡的方法。