利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

189 条记录 (耗时 0.018 秒)

    TREATMENT WITH KALLIKREIN INHIBITORS
    3.
    发明申请
    TREATMENT WITH KALLIKREIN INHIBITORS 审中-公开
    用KALLIKREIN抑制剂治疗

    公开(公告)号：WO2009026539A1

    公开(公告)日：2009-02-26

    申请号：PCT/US2008/074061

    申请日：2008-08-22

    申请人： GENZYME CORPORATION ,  MOSCICKI, Richard

    发明人： MOSCICKI, Richard

    IPC分类号： A61K38/16

    CPC分类号： C07K14/8114 ,  A61K38/00

    摘要： Methods, kits and compositions are disclosed that include a non-naturally occurring kallikrein inhibitor and an optional additional gout therapeutic for the treatment of gout, such as acute gout.

    摘要翻译： 公开了包括非天然存在的激肽释放酶抑制剂和用于治疗痛风的任选额外的痛风治疗剂，例如急性痛风的方法，试剂盒和组合物。

    PROTEINS
    6.
    发明申请
    PROTEINS 审中-公开
    蛋白质

    公开(公告)号：WO2006134342A2

    公开(公告)日：2006-12-21

    申请号：PCT/GB2006/002157

    申请日：2006-06-13

    申请人： MERCK SHARP & DOHME LIMITED ,  BEHER, Dirk ,  WRIGLEY, Jonathan, David

    发明人： BEHER, Dirk ,  WRIGLEY, Jonathan, David

    IPC分类号： C07K14/47 ,  C12N15/85 ,  G01N33/68

    CPC分类号： C07K14/4711 ,  A01K2217/05 ,  A01K2267/0312 ,  C07K14/8114 ,  C12N15/8509

    摘要： A modified amyloid precursor protein can be expressed from a DNA construct comprising an APP DNA sequence, or a fragment or artificial substrate thereof, encoding the mutation I45W, I45Y, V46W or V46Y (numbering relative to A4CT); the use of the DNA construct in the generation of cell lines or transgenic animals and the use of these proteins or such transgenic animals in the diagnosis of Alzheimer's Disease and screening putative drugs against Alzheimer's Disease are also described.

    摘要翻译： 修饰的淀粉样蛋白前体蛋白可以由包含APP DNA序列或其片段或人造底物的DNA构建体表达，编码突变I45W，I45Y，V46W或V46Y（编号相对于A4CT）; 也描述了DNA构建体在产生细胞系或转基因动物中的使用以及这些蛋白质或这种转基因动物在诊断阿尔茨海默病和筛选对阿尔茨海默病的推定药物中的用途。

    INTERALPHA TRYPSIN INHIBITOR BIOPOLYMER MARKERS INDICATIVE OF INSULIN RESISTANCE
    8.
    发明申请
    INTERALPHA TRYPSIN INHIBITOR BIOPOLYMER MARKERS INDICATIVE OF INSULIN RESISTANCE 审中-公开
    表明胰岛素抵抗的Interpha胰蛋白酶抑制剂生物聚合物标志物

    公开(公告)号：WO2003046005A2

    公开(公告)日：2003-06-05

    申请号：PCT/CA2002/001659

    申请日：2002-10-31

    申请人： SYN.X PHARMA, INC.

    发明人： JACKOWSKI, George ,  MARSHALL, John

    IPC分类号： C07K14/81

    CPC分类号： C07K14/8114 ,  Y10T436/24

    摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer, predict disease risk assessment, and develop therapeutic avenues against said disease.

    摘要翻译： 本发明涉及使用与质谱法和飞行时间检测程序结合的预备步骤的组合以最大化可在特定样品内验证的生物聚合物的多样性。 然后参照它们证明至少一种特定疾病状态的能力来观察在这样的样品中验证的生物聚合物群组; 由此使得诊断者能够获得表征所述至少一种疾病状态相对于识别所述生物聚合物的存在和/或不存在，预测疾病风险评估以及开发针对所述疾病的治疗途径的存在或不存在的能力。