公开(公告)号：WO2015087092A2

公开(公告)日：2015-06-18

申请号：PCT/GB2014/053703

申请日：2014-12-15

Applicant: BIO AMD HOLDINGS LIMITED

Inventor： DJENNATI, Nasr-Eddine ,  MITCHELL, Andrew

CPC classification number: B01L3/502738 ,  A61M39/22 ,  B01L2400/0633 ,  F16K99/0011 ,  F16K99/0046 ,  F16K2099/0086

Abstract: An assay apparatus for determining properties of a sample. The apparatus has first and second chambers for receiving a sample. The first and second chambers are linked by a conduit along which at least part of the sample may travel so that the sample can move from the first chamber to the second chamber in series. The apparatus also has a slot extending from the conduit and a valve body comprising magnetic or magnetically susceptible material which is housed at least substantially within the slot. The valve body is movable between a first position in which the valve body is arranged at least substantially outside the conduit and a second position in which the valve body extends across the conduit thereby restricting a sample from travelling along the conduit from the first chamber to the second chamber. The valve body is slidably movable between the two positions by an external magnetic field.

Abstract translation: 一种用于确定样品特性的测定装置。 该装置具有用于接收样品的第一和第二室。 第一和第二腔室通过导管连接，导管至少部分样品可以沿其移动，使得样品可以从第一腔室串联移动到第二腔室。 该设备还具有从导管延伸的槽和包括至少基本上容纳在槽内的磁性或磁性敏感材料的阀体。 阀体可在第一位置和第二位置之间移动，其中阀体至少基本上布置在导管的外侧，阀体延伸穿过管道的第二位置，从而限制样品沿导管从第一室向第 第二室。 阀体通过外部磁场在两个位置之间可滑动地移动。

公开(公告)号：WO2011128696A1

公开(公告)日：2011-10-20

申请号：PCT/GB2011/050749

申请日：2011-04-14

Applicant: BIO AMD HOLDINGS LIMITED ,  MITCHELL, Andrew ,  DJENNATI, Nasser

Inventor： MITCHELL, Andrew ,  DJENNATI, Nasser

IPC: B01L3/00

CPC classification number: G01N33/53 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0816 ,  B01L2400/043

Abstract: An assay apparatus having an assay strip (6). The assay strip (6) has a first area (2) with a plurality of magnetic particles bonded thereto. The assay strip (6) also has a microfluidic (or nanofluidic) channel or chamber, having a sensing area comprising one or more magnetic particle traps (7, 8, 9) and a magnetic field source (5) provided adjacent to the sensing area. Introduction of a fluid causes the magnetic particles to become attached to or displaced by a substance of interest, travel along the microfluidic channel to the sensing area and become concentrated in the one or more traps (7, 8, 9) thus providing an indication of the presence or absence of a substance of interest in the fluid. There may be a plurality of traps (7, 8, 9).

Abstract translation: 具有测定条（6）的测定装置。 测定条（6）具有与其结合的多个磁性颗粒的第一区域（2）。 测定条（6）还具有微流体（或纳流体）通道或室，其具有包括一个或多个磁性颗粒捕集器（7,8,9）的感测区域和邻近感测区域设置的磁场源（5） 。 引入流体导致磁性颗粒附着到感兴趣的物质或被其移动，沿着微流体通道行进到感测区域并变得集中在一个或多个捕集器（7,8,9）中，从而提供指示 在流体中存在或不存在感兴趣的物质。 可能有多个陷阱（7,8,9）。

公开(公告)号：WO2016092333A3

公开(公告)日：2016-06-16

申请号：PCT/GB2015/053975

申请日：2015-12-14

Applicant: BIO AMD HOLDINGS LIMITED

Inventor： DJENNATI, Nasr-Eddine ,  MITCHELL, Andrew ,  BANKS, Dominic

IPC: B01L3/00 ,  B01F13/00 ,  G01N33/49

Abstract: An assay apparatus (1) for determining properties of a sample, such as coagulation properties of blood comprises first and second chambers (3, 5) for receiving the sample. The chambers are arranged so that the sample can move downstream from the first chamber (3) to the second chamber (5) in series. The apparatus (1) is provided with an openable valve or vent (8) arranged such that opening the valve or vent (8) allows flow from the first chamber (3) to the second chamber (5). The openable vent (8) can be located in, or downstream of the second chamber (5) and can be opened by moving a closure to reveal holes, or by puncturing a layer to open the passage. In another embodiment, a valve (112) in an assay apparatus may be formed of a frustoconical seat (114) and a spherical body (116).

公开(公告)号：WO2013150306A1

公开(公告)日：2013-10-10

申请号：PCT/GB2013/050882

申请日：2013-04-04

Applicant: BIO AMD HOLDINGS LIMITED

Inventor： DJENNATI, Nasr-Eddine ,  MITCHELL, Andrew

IPC: H01L27/142 ,  G01N21/00 ,  G01N33/53 ,  G01N33/76

CPC classification number: G01J1/42 ,  G01N21/8483 ,  G01R31/26 ,  G01R31/40 ,  H01L31/042 ,  H01L31/046 ,  H01L31/10 ,  H02S50/10 ,  Y02E10/50

Abstract: A photovoltaic sensor array for detecting variations in light intensity. The array has a plurality of photovoltaic cells which are electrically independent from one another and formed on a common substrate. Each cell has corresponding positive and negative electrical connections and each cell is arranged to detect light intensity so that variations in light intensity between the cells can be obtained.

Abstract translation: 一种光电传感器阵列，用于检测光强度的变化。 阵列具有彼此电独立并形成在公共基板上的多个光伏电池。 每个单元具有对应的正和负电连接，并且每个单元被布置成检测光强度，使得可以获得单元之间的光强度的变化。

公开(公告)号：WO2012004612A1

公开(公告)日：2012-01-12

申请号：PCT/GB2011/051292

申请日：2011-07-11

Applicant: BIO AMD HOLDINGS LIMITED ,  MITCHELL, Andrew ,  DJENNATI, Nasser

Inventor： MITCHELL, Andrew ,  DJENNATI, Nasser

IPC: B01L3/00 ,  G01N33/49 ,  G01N11/16

CPC classification number: G01N33/4905 ,  B01L3/5027 ,  B01L3/502715 ,  B01L9/527 ,  B01L2200/027 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0825 ,  B01L2300/0864 ,  B01L2300/1805 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/043 ,  G01N1/31 ,  G01N11/14 ,  G01N15/1434 ,  G01N2011/147

Abstract: Apparatus (1) for determining a property of a sample. The apparatus has a chamber (11, 13) for receiving at least a part of the sample and contains a rotor (15) adapted to rotate within the chamber (11, 13). The apparatus (1) also has a space (17) between the rotor (15) and the chamber (11, 13) which may be at least partially occupied by the sample, driving means (14) for rotating the rotor (15), and a detector (39) arranged to detect the rate of rotation of the rotor (15). The apparatus may also have two parts, a sample strip (5) for receiving the sample and a receiving member (3) for receiving the sample strip (5) and carrying out measurements on the sample. The rotor (15) may be magnetised across its diameter. The driving means (14) may be a magnetic driving means. The sample may be a blood sample. The property to be determined by the sample may be the prothrombin time of the blood or plasma.

Abstract translation: 用于确定样品性质的装置（1）。 该装置具有容纳至少一部分样品并包含适于在腔室（11,13）内旋转的转子（15）的腔室（11,13）。 设备（1）还具有在转子（15）和腔室（11,13）之间的空间（17），该空间可至少部分地被样品占据，用于使转子（15）旋转的驱动装置（14） 以及布置成检测转子（15）的旋转速率的检测器（39）。 该装置还可以具有两个部分：用于接收样品的样品条（5）和用于接收样品条（5）并对样品进行测量的接收部件（3）。 转子（15）可以在其直径上被磁化。 驱动装置（14）可以是磁驱动装置。 样品可以是血液样品。 由样品确定的性质可以是血液或血浆的凝血酶原时间。

公开(公告)号：WO2013150279A1

公开(公告)日：2013-10-10

申请号：PCT/GB2013/050827

申请日：2013-03-28

Applicant: BIO AMD HOLDINGS LIMITED

Inventor： DJENNATI, Nasr-Eddine ,  MITCHELL, Andrew

IPC: A61B10/00 ,  G01N33/76

CPC classification number: A61B10/007 ,  A61B10/0012

Abstract: A cartridge for test apparatus arranged to receive a sample to be tested and to releasably engage with a reader to enable a sample received by the cartridge to be analysed. The cartridge has a movable cover arranged to cover a part of the cartridge at which a sample to be tested is received and a latch means arranged to prevent the cover being moved to expose the part of the cartridge at which a sample to be tested is received unless the cartridge is engaged with a reader. The cover may be a cap. The latch may be formed by a wedge shaped protrusion on the cap arranged to be received into an aperture in the remainder of the cartridge. The cartridge prevents a sample being introduced before it is engaged with a reader.

Abstract translation: 一种用于测试设备的盒，被布置成接收待测试的样品并且与读取器可释放地接合以使得能够分析由盒接收的样品。 盒具有可移动盖，其布置成覆盖待测试样品被容纳的盒的一部分;以及闩锁装置，其布置成防止盖被移动以暴露待测样品被接收到的盒的部分 除非墨盒与阅读器接合。 盖子可以是盖子。 闩锁可以由盖上的楔形突起形成，其布置成被容纳在盒的其余部分中的孔中。 墨盒防止样品在与读取器接合之前被引入。