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    MICROFLUID CHIP-BASED, UNIVERSAL COAGULATION ASSAY
    2.
    发明申请
    MICROFLUID CHIP-BASED, UNIVERSAL COAGULATION ASSAY 审中-公开
    基于微芯片芯片，通用凝聚测定

    公开(公告)号：WO2016040490A1

    公开(公告)日：2016-03-17

    申请号：PCT/US2015/049198

    申请日：2015-09-09

    Applicant: PEROSPHERE, INC.

    Inventor： BAKHRU, Sasha ,  LAULICHT, Bryan ,  ZAPPE, Stefan ,  STEINER, Solomon

    IPC: G01N33/49 ,  B01L3/00

    CPC classification number: G01N33/86 ,  B01L3/502715 ,  B01L9/527 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/1827 ,  G01N33/4905

    Abstract: A microfluidic, chip-based assay device has been developed for measuring physical properties of an analyte (particularly, whole blood or whole blood derivatives). The technologies can be applied to measure clotting times of whole blood or blood derivatives, determine the effects of anticoagulant drugs on the kinetics of clotting/coagulation, as well as evaluate the effect of anticoagulant reversal agents. These technologies can additionally be used to optimize the dosage of anticoagulation drugs and/or their reversal agents. The assay is independent of the presence of anticoagulant; clotting is activated by exposure of the blood sample in the device to a glass (or other negatively charged material such as oxidized silicon) surface, which activates the intrinsic pathway and can be further hastened by the application of shear flow across the activating materials surface. The absence of chemical activating agents and highly controlled and reproducible micro-environment yields a point of care universal clotting assay.

    Abstract translation: 已经开发了用于测量分析物（特别是全血或全血衍生物）的物理性质的微流体，基于芯片的测定装置。 该技术可用于测量全血或血液衍生物的凝血时间，确定抗凝药物对凝血/凝血动力学的影响，以及评估抗凝剂逆转剂的作用。 这些技术还可用于优化抗凝药物和/或其逆转剂的剂量。 该测定法与抗凝剂的存在无关; 通过将装置中的血液样品暴露于玻璃（或其它带负电荷的材料，例如氧化硅）表面来激活凝固，其激活本征途径，并且可以通过在活化材料表面施加剪切流而进一步加速。 没有化​​学活化剂和高度可控和可重复的微环境产生一个关键点通用凝血测定。

    CAPILLARY ASSAY DEVICE WITH INTERNAL HYDOPHYLIC COATING
    3.
    发明申请
    CAPILLARY ASSAY DEVICE WITH INTERNAL HYDOPHYLIC COATING 审中-公开
    具有内部涂层涂层的毛细管测试装置

    公开(公告)号：WO2016012778A1

    公开(公告)日：2016-01-28

    申请号：PCT/GB2015/052107

    申请日：2015-07-22

    Applicant: LOUGHBOROUGH UNIVERSITY

    Inventor： EDWARDS, Alexander Daniel ,  REIS, Nuno Miguel Fernandes

    IPC: G01N33/552

    CPC classification number: B01L3/50273 ,  B01L3/502707 ,  B01L3/502715 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/06 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2300/0825 ,  B01L2300/0861 ,  B01L2300/161 ,  B01L2300/168 ,  B01L2400/0406 ,  B01L2400/0457 ,  G01N33/552

    Abstract: The present invention provides assay devices having a unitary body with an exterior surface, the unitary body being substantially transparent to visible light and formed from a material having a refractive index in the range 1.26 to 1.40, the refractive index being measured at 20 °C with light of wavelength 589 nm, and wherein the unitary body is formed from a hydrophobic material, and at least two capillary bores extending internally along the unitary body, wherein at least a portion of the surface of each capillary bore includes a hydrophilic layer for retaining an assay reagent, and wherein the hydrophilic layer is also substantially transparent to visible light to allow optical interrogation of the capillary bores through the capillary wall. The present invention also provides assay systems including such assay devices, methods of performing an assay using such assay devices and method of method for manufacturing such assay devices.

    Abstract translation: 本发明提供具有整体的具有外表面的测定装置，所述整体对可见光基本透明并且由折射率在1.26至1.40范围内的材料形成，折射率在20℃下用 波长589nm的光，并且其中整体由疏水材料形成，并且至少两个毛细孔沿着整体主体内部延伸，其中每个毛细孔的表面的至少一部分包括亲水层，用于保持 测定试剂，并且其中亲水层对可见光也基本透明，以允许毛细孔通过毛细管壁进行光学询问。 本发明还提供了包括这种测定装置的测定系统，使用这种测定装置进行测定的方法和用于制造这种测定装置的方法的方法。

    DEVICE FOR PREPARING A SUBSTRATE FOR PROCESSING SAMPLES
    5.
    发明申请
    DEVICE FOR PREPARING A SUBSTRATE FOR PROCESSING SAMPLES 审中-公开
    用于制备加工样品的基材的装置

    公开(公告)号：WO2015121343A1

    公开(公告)日：2015-08-20

    申请号：PCT/EP2015/052951

    申请日：2015-02-12

    Applicant: TETHIS S.P.A.

    Inventor： BANDIERA, Dario ,  BARBORINI, Emanuele ,  FRANCHI, Gian Martino ,  GATELLI, Massimo

    IPC: B01L3/00 ,  B01L9/00

    CPC classification number: B01L9/52 ,  B01L3/5027 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/0689 ,  B01L2300/0816 ,  B01L2300/0822 ,  B01L2300/0887 ,  B01L2300/123

    Abstract: A device (1) for preparing a substrate (S) for processing samples comprises at least a cover (3) having a contact surface (3a) configured to come into contact with a substrate (S) and sealing means (4) located on the contact surface (3a) for latching onto the substrate (S), the cover (3) has a peripheral rim (3b) and an aperture (5) for handling fluids; a frame (6) having an engagement surface (6a) to be coupled with the substrate (S) and at least a window (7) into the engagement surface (6a), said window (7) having an edge (7a) to engage the rim (3b) for holding said cover (3) in a predetermined position with respect to the frame (6).

    Abstract translation: 用于制备用于处理样品的衬底（S）的装置（1）至少包括具有接触表面（3a）的盖（3），所述接触表面（3a）被配置为与衬底（S）接触，并且密封装置 接触表面（3a）用于锁定到基底（S）上，盖（3）具有周边边缘（3b）和用于处理流体的孔（5） 具有与所述基板（S）连接的接合表面（6a）和至少一个窗口（7）进入所述接合表面（6a）的框架（6），所述窗口（7）具有边缘（7a）以接合 用于将所述盖（3）保持在相对于框架（6）的预定位置的边缘（3b）。

    INTEGRATED MULTIPLEX TARGET ANALYSIS
    8.
    发明申请
    INTEGRATED MULTIPLEX TARGET ANALYSIS 审中-公开
    综合多目标分析

    公开(公告)号：WO2014066704A1

    公开(公告)日：2014-05-01

    申请号：PCT/US2013/066717

    申请日：2013-10-24

    Applicant: GENMARK DIAGNOSTICS, INC.

    Inventor： KAYYEM, Jon, Faiz ,  SRINIVASAN, Jay

    IPC: G01N13/02 ,  G01N27/26 ,  G01N33/00 ,  C12Q1/68 ,  C12M1/34 ,  B01L3/00 ,  F16H21/00 ,  F16H25/00 ,  B65D81/32

    CPC classification number: C12Q1/6825 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/502784 ,  B01L3/523 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/0672 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/0427 ,  B01L2400/0481 ,  B01L2400/0683

    Abstract: A biochip cartridge comprising: a) a bottom substrate comprising a printed circuit board (PCB) comprising: i) an electrowetting grid of electrodes forming a droplet pathway; ii) an array of detection electrodes accessible to said droplet pathway, each comprising a self-assembled monolayer and a capture probe; iii) a plurality of interconnections from said electrowetting grid and said detection electrodes; and b) a top plate comprising a conductive surface parallel to said bottom substrate and mated thereto to form a reaction chamber. Furthermore, a method of detecting target nucleic acids, an apparatus for processing fluid, and a fluid container are also disclosed. The method of detecting target nucleic acids include adding binding buffer and capture beads to the sample, eluting the target nucleic acids from the beads and amplifying them to form amplicans, adding signalling probes to the amplicons to form hybridization complexes, and binding the hybridization complexes to capture probes to form and detect assay complexes. The apparatus for processing a fluid comprises a collapsible vessel including a first actuator, a second actuator which are coupled through a motion conversion mechanism. The first described fluid container comprises a first vessel, a second vessel, a sealing partition, and an opening device to open the sealing partition. The second described fluid container comprises a collapsible vessel surrounded by a housing and means to apply an external pressure to displace fluid from the vessel.

    Abstract translation: 一种生物芯片盒，包括：a）包括印刷电路板（PCB）的底部基板，包括：i）形成液滴通道的电极的电润湿网格; ii）可由所述液滴通道接近的检测电极阵列，每个包括自组装单层和捕获探针; iii）来自所述电润湿网格和所述检测电极的多个互连; 以及b）顶板，其包括平行于所述底部基板的导电表面并与之配合以形成反应室。 此外，还公开了检测靶核酸的方法，用于处理流体的装置和流体容器。 检测靶核酸的方法包括向样品中加入结合缓冲液和捕获珠，从珠中洗脱靶核酸并扩增其形成扩增子，向扩增子加入信号探针以形成杂交复合物，并将杂交复合物结合到 捕获探针以形成和检测测定复合物。 用于处理流体的装置包括可折叠容器，其包括第一致动器，通过运动转换机构联接的第二致动器。 第一种描述的流体容器包括第一容器，第二容器，密封隔板和用于打开密封隔板的打开装置。 第二种描述的流体容器包括由壳体包围的可折叠容器和用于施加外部压力以从容器移置流体的装置。

    FLEXIBLE DNA SENSOR CARRIER AND METHOD
    9.
    发明申请
    FLEXIBLE DNA SENSOR CARRIER AND METHOD 审中-公开
    灵活的DNA传感器载体和方法

    公开(公告)号：WO2014008518A1

    公开(公告)日：2014-01-16

    申请号：PCT/AT2012/000182

    申请日：2012-07-10

    Applicant: LEXOGEN GMBH ,  REDA, Thorsten ,  HOLLÄNDER, Igor

    Inventor： REDA, Thorsten ,  HOLLÄNDER, Igor

    IPC: G01N33/543 ,  B01L3/00

    CPC classification number: C12Q1/6837 ,  B01L3/502707 ,  B01L3/502715 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/0689 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/123 ,  G01N27/02

    Abstract: The invention relates to a sensor carrier comprising a flexible film (1) comprising a plurality of functionalized sensor elements (4) each being formed by a functional layer, wherein the functional layers are located on the same surface of the film (1) within a window area (6), wherein a region (7) of each of the functional layers of the sensor elements (4) is functionalized, and wherein one or more sensor compounds (5) are arranged or located in the respective functionalized regions (7) of the sensor elements (4).

    Abstract translation: 本发明涉及一种传感器载体，其包括柔性膜（1），其包括多个功能化的传感器元件（4），每个功能化传感器元件由功能层形成，其中功能层位于膜（1）的同一表面上， 窗口区域（6），其中传感器元件（4）的每个功能层的区域（7）被功能化，并且其中一个或多个传感器化合物（5）被布置或位于各个功能化区域（7）中， 的传感器元件（4）。

    ELECTROPHORESIS GEL CASSETTE WITH AT LEAST ONE REMOVABLE SECTION
    10.
    发明申请
    ELECTROPHORESIS GEL CASSETTE WITH AT LEAST ONE REMOVABLE SECTION 审中-公开
    电泳凝胶与至少一个可拆卸的部分

    公开(公告)号：WO2013180637A1

    公开(公告)日：2013-12-05

    申请号：PCT/SE2013/050631

    申请日：2013-05-31

    Applicant: GE HEALTHCARE BIO-SCIENCES AB

    Inventor： BJORKESTEN, Lennart ,  SALVEN, Owe ,  LARSSON, Camilla ,  BJERNELD, Erik, J ,  EDLUND, Sofia ,  OSTLIN, Henrik ,  SJOLANDER, Stefan ,  STRIDSBERG-FRIDEN, Kajsa ,  RONN, Ola ,  OLIVIUSSON, Peter ,  BJORKMAN, Henrik

    IPC: G01N27/447

    CPC classification number: G01N27/44743 ,  B01L9/527 ,  G01N27/44704 ,  G01N27/44756

    Abstract: Electrophoresis gel cassette comprising a first and a second face wall member and one or more side wall members, defining a gel compartment for a gel member with a first and second face, wherein the first face wall member has high gel adhesion compared to the second face wall member, whereby a gel member molded in the cassette will stay attached to the high gel adhesion face wall member when the cassette is opened, and wherein the first face wall member is provided with at least one removable section to expose a section of the first face of the gel member, the removable section of the first face wall member having lower gel adhesion compared to the non-removable part of the first face wall member.

    Abstract translation: 电泳凝胶盒，包括第一和第二面壁构件和一个或多个侧壁构件，其限定具有第一和第二面的凝胶构件的凝胶室，其中第一面壁构件与第二面相比具有高凝胶粘附力 其中当所述盒被打开时，模制在所述盒中的凝胶构件将保持附着到所述高凝胶粘附面壁构件，并且其中所述第一面壁构件设置有至少一个可移除部分，以暴露所述第一 凝胶构件的表面，与第一面壁构件的不可移除部分相比，第一面壁构件的可移除部分具有较低的凝胶粘附。

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