公开(公告)号：WO2023086871A2

公开(公告)日：2023-05-19

申请号：PCT/US2022/079616

申请日：2022-11-10

Applicant: ELI LILLY AND COMPANY

Inventor： CHAO, Grace ,  FENG, Yiqing ,  LEUNG, Donmienne Doen Mun ,  NA, Songqing ,  RAMAMURTHY, Bharathi ,  XU, Jianghuai

IPC: C07K16/24 ,  A61K39/395 ,  A61P37/06 ,  A61K39/00

Abstract: The present disclosure relates to antibodies that specifically bind soluble and membrane forms of human TNFα, compositions comprising such TNFα antibodies, and methods of using such TNFα antibodies and compositions.

公开(公告)号：WO2023077042A1

公开(公告)日：2023-05-04

申请号：PCT/US2022/078837

申请日：2022-10-28

Applicant: ELI LILLY AND COMPANY

Inventor： CHEDID, Marcio ,  FLEISHER, Adam S. ,  LANNAN, Megan Brittany ,  LO, Albert ,  MINTUN, Mark ,  OBUNGU, Victor H. ,  RAINES, Sarah Elisabeth ,  SIMS, John Randall II ,  SKORA, Andrew Dixon ,  WALSH, Robin Elizabeth ,  WEST, Elizabeth Anne ,  YE, Ming

IPC: A61P25/00 ,  C07K16/24

Abstract: The present disclosure relates to IL-34 antibodies, compositions comprising the same, and methods of using the antibodies and or compositions thereof for treating immune-mediated diseases such as neurodegenerative diseases, for example Alzheimer's Disease or a tauopathy disease.

公开(公告)号：WO2023044280A1

公开(公告)日：2023-03-23

申请号：PCT/US2022/076267

申请日：2022-09-12

Applicant: ELI LILLY AND COMPANY

Inventor： DUTTA, Supratik ,  SHEN, Juqun ,  SKORA, Andrew Dixon ,  WANG, Cheng

IPC: C07K16/24

Abstract: The present invention provides engineered human interleukin-1 beta antibodies, cells and vectors comprising DNA encoding the same, and methods for producing the antibodies. In addition, the present invention provides the use of the human engineered interleukin-1-beta antibodies for the treatment of inflammatory disease, such as cardiovascular disease and cancer.

公开(公告)号：WO2023039278A1

公开(公告)日：2023-03-16

申请号：PCT/US2022/043308

申请日：2022-09-13

Applicant: ELI LILLY AND COMPANY

Inventor： CARSON, Cheryl Ann ,  CLARKE, Christian Alexander ,  GERNERT, Douglas Linn ,  GREEN, Steven James ,  HOLLOWAY, William Glen ,  BARRETT, David Gene

IPC: C07D211/88 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D491/04 ,  A61K31/517 ,  A61K31/444 ,  A61K31/427 ,  A61K31/433 ,  A61K31/4245 ,  A61K31/423 ,  A61K31/404 ,  A61P37/00

Abstract: The present invention relates to certain substituted AHR agonist compounds, to pharmaceutical compositions comprising the compounds and to methods of using the compounds to treat immune-mediated diseases.

公开(公告)号：WO2023039275A1

公开(公告)日：2023-03-16

申请号：PCT/US2022/043299

申请日：2022-09-13

Applicant: ELI LILLY AND COMPANY

Inventor： CHAUVIGNE-HINES, Lacie Marie ,  CLARKE, Christian Alexander ,  GERNERT, Douglas Linn ,  GREEN, Steven James ,  WATSON, Brian Morgan

IPC: C07D215/06 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D471/04 ,  A61K31/4375 ,  A61K31/4704 ,  A61K31/4709 ,  A61P37/00

Abstract: The present invention relates to certain substituted AHR agonist compounds, to pharmaceutical compositions comprising the compounds and to methods of using the compounds to treat immune-mediated diseases.

公开(公告)号：WO2023023489A2

公开(公告)日：2023-02-23

申请号：PCT/US2022/074981

申请日：2022-08-15

Applicant: HEMOGENYX PHARMACEUTICALS LLC ,  ELI LILLY AND COMPANY

Inventor： SANDLER, Vladislav M. ,  SHRESTHA, Elina ,  SIROCHINSKY, Carina Rachel ,  LIANG, Raymond ,  BEN JEHUDA, Ronen ,  KORYTKO, Andrew Ihor ,  SKORA, Andrew Dixon ,  ADER, Max Ephraim ,  CHILTON, Todd Christopher

IPC: C07K16/28 ,  A61P35/00 ,  A61K2039/505 ,  C07K16/2809 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/622 ,  C07K2317/92

Abstract: Provided herein are bispecific anti-FLT3/CD3 antibodies and antigen binding fragments thereof, such as the antibodies and fragments that specifically bind human FLT3 and human CD3. In some aspects, provided herein are optimized humanized, bispecific anti-FLT3/CD3 antibodies and antigen binding fragments thereof, optionally, having certain amino acid substitutions that confer advantageous properties (e.g., optimal antigen binding, manufacturability and/or half-life properties). Also provided herein are pharmaceutical compositions comprising such antibodies or fragments. Also provided herein are methods of use of such antibodies and fragments.

公开(公告)号：WO2023009767A1

公开(公告)日：2023-02-02

申请号：PCT/US2022/038744

申请日：2022-07-29

Applicant: ELI LILLY AND COMPANY

Inventor： GROND, Susanne ,  RIEDL, Elisabeth

IPC: A61K31/519 ,  A61P17/00

Abstract: Methods of treating Hand Eczema with baricitinib, including formulations and dose regimens. The amount of baricitinib may be administered as a 4 mg tablet or pill that includes one or more excipients. The amount of baricitinib may be administered daily or at some other frequency.

公开(公告)号：WO2022271767A1

公开(公告)日：2022-12-29

申请号：PCT/US2022/034437

申请日：2022-06-22

Applicant: ELI LILLY AND COMPANY

Inventor： COSKUN, Tamer ,  MILICEVIC, Zvonko ,  URVA, Shweta

IPC: A61K38/26 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  C07K14/605

Abstract: Doses and dosing regimens for incretin analogs are disclosed comprising determining and administering doses of long-acting incretin analogs suitable for once-weekly dosing, such as a glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1) and glucagon (GCG) (GGG) tri-receptor agonist.

公开(公告)号：WO2022246078A1

公开(公告)日：2022-11-24

申请号：PCT/US2022/030058

申请日：2022-05-19

Applicant: ELI LILLY AND COMPANY

Inventor： BEIDLER, Catherine Brautigam ,  BOYLES, Jeffrey Streetman ,  GIRARD, Daniel Scott ,  HARLAN, Shannon Marie ,  JOHNSON, Michael Parvin

IPC: C07K16/26 ,  A61P25/02 ,  A61P29/00 ,  A61K39/395 ,  A61K39/00 ,  A61K39/3955 ,  A61P25/04 ,  C07K16/22 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N2333/485 ,  G01N33/74

Abstract: The present invention relates to epiregulin antibodies, compositions comprising the same, and methods of making and/or using the antibodies and/or compositions thereof for chronic pain disorders such as chronic osteoarthritis pain, or chronic diabetic peripheral neuropathy pain, or chronic low back pain.

公开(公告)号：WO2022246019A1

公开(公告)日：2022-11-24

申请号：PCT/US2022/029958

申请日：2022-05-19

Applicant: ELI LILLY AND COMPANY

Inventor： AGEJAS CHICHARRO, Francisco Javier ,  BAUER, Renato Alejandro ,  BELL, Michael Gregory ,  CHEN, Qi ,  CUMMING, Graham Robert ,  FIELDS, Todd ,  GERNERT, Douglas Linn ,  HO, Joseph Daniel ,  KAOUDI, Talbi Abelkader ,  MASQUELIN, Thierry Jean ,  MÍNGUEZ ORTEGA, José Miguel ,  PRIEGO SOLER, Julian ,  RODRIGUEZ HERGUETA, Antonio ,  WOERLY, Eric Michael

IPC: C07D405/06 ,  C07D498/08 ,  A61P3/10 ,  A61K31/439 ,  A61K31/529 ,  A61K31/4184

Abstract: In an embodiment, the present invention provides a compound of the formula: or a pharmaceutically acceptable salt thereof, and methods of using this compound for treating type II diabetes mellitus.