公开(公告)号：WO2023012314A1

公开(公告)日：2023-02-09

申请号：PCT/EP2022/072030

申请日：2022-08-04

申请人： LIFEARC ,  MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.

发明人： WORZFELD, Thomas ,  OFFERMANNS, Stefan ,  MATTHEWS, David ,  OLEKSY, Arkadiusz ,  TROKTER, Martina ,  PATEL, Seema ,  KAUR NIJJAR, Sharandip

IPC分类号： A61P19/10 ,  A61P25/00 ,  C07K16/28 ,  C07K16/2896 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/76

摘要： The invention relates to antibodies and antigen binding fragments thereof that specifically bind to Plexin-B1 and their therapeutic uses. The antibodies are useful in treating osteoporosis, multiple sclerosis, a neoplastic disease or a neurodegenerative disease in a subject.

公开(公告)号：WO2023004431A2

公开(公告)日：2023-01-26

申请号：PCT/US2022/074075

申请日：2022-07-22

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： HO, David, D. ,  HUANG, Yaoxing ,  LIU, Lihong ,  NAIR, Manoj, S. ,  YU, Jian ,  IKETANI, Sho

IPC分类号： A61K39/42 ,  A61P31/14 ,  C07K16/10 ,  C12N15/13 ,  C12N15/63 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/76 ,  C07K2317/92

摘要： The subject matter described herein relates to engineered monoclonal antibodies, derived from antibodies isolated from human patients, neutralizing a SARS-CoV-2 virus, its variants, or related coronaviruses.

公开(公告)号：WO2023287573A2

公开(公告)日：2023-01-19

申请号：PCT/US2022/035376

申请日：2022-06-28

申请人： MABWELL THERAPEUTICS INC.

发明人： CHEN, Buxin ,  HUANG, Lei ,  DU, Xin

IPC分类号： A61P37/06 ,  C07K16/18 ,  C07K16/40 ,  A61K39/00 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： Antibodies and antigen-binding fragments thereof that bind C1s and inhibit C1s activity and modulate the activity of at least one component in the classical pathway (CP) of complement activation, and methods for treating complement-mediated disorders using anti-C1s antibodies and fragments, are provided.

公开(公告)号：WO2023283611A1

公开(公告)日：2023-01-12

申请号：PCT/US2022/073523

申请日：2022-07-07

申请人： STAIDSON BIOPHARMA INC.

发明人： YI, Zuoan ,  ZHAI, Wenwu ,  HE, Chong ,  YANG, Lifei

IPC分类号： C07K16/28 ,  A61P35/00 ,  A61K39/395 ,  A61K2039/505 ,  C07K16/2878 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： The present application provides anti-TNFR2 antibodies, nucleic acid molecules encoding an amino acid sequence of the anti-TNFR2 antibodies, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of preparing the anti-TNFR2 antibodies, pharmaceutical compositions containing the anti-TNFR2 antibodies, and methods of using the anti-TNFR2 antibodies or compositions.

公开(公告)号：WO2023283211A2

公开(公告)日：2023-01-12

申请号：PCT/US2022/036166

申请日：2022-07-06

申请人： THE CHILDREN'S MEDICAL CENTER CORPORATION ,  PFIZER INC. ,  GAO, Hulian

发明人： CARROLL, Michael C. ,  KOVALENKO, Oleg Victorovich ,  BENNETT, Eric Matthew ,  BUHLMANN, Janet Elizabeth ,  MIN DEBARTOLO, Jessica Haewon ,  GULLA, Stefano Vincenzo ,  HIGGINSON-SCOTT, Nathan ,  KARLSSON, Fridrik Jensen ,  SOLER-FERRAN, Dulce ,  TANG, Xianchun

IPC分类号： C07K16/30 ,  A61P35/00 ,  C07K16/28 ,  C07K16/2896 ,  C07K2317/33 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

摘要： Provided herein are anti-CD21 antibodies or antigen binding fragments thereof and their use in the treatment of autoimmune diseases or disorders.

公开(公告)号：WO2022266659A1

公开(公告)日：2022-12-22

申请号：PCT/US2022/072995

申请日：2022-06-16

申请人： GENENTECH, INC.

发明人： KIRKPATRICK, Donald S. ,  KOERBER, James T. ,  DAVIES, Christopher W.

IPC分类号： C07K16/18 ,  G01N33/53 ,  C07K2317/20 ,  C07K2317/32 ,  C07K2317/33 ,  C07K2317/34 ,  G01N33/6854

摘要： Provided herein are antibodies that bind to a peptide of an N-terminally ubiquitinated polypeptide and methods of screening for such antibodies. Also provided herein are detection and enrichment methods using such antibodies for detecting or enriching a peptide of an N-terminally ubiquitinated polypeptide.

公开(公告)号：WO2022258714A1

公开(公告)日：2022-12-15

申请号：PCT/EP2022/065600

申请日：2022-06-08

申请人： OSE IMMUNOTHERAPEUTICS ,  NANTES UNIVERSITÉ ,  INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE

发明人： PENGAM, Sabrina ,  GAUTTIER, Vanessa ,  MARY, Caroline ,  POIRIER, Nicolas ,  DROUIN, Marion ,  CHIFFOLEAU, Elise

IPC分类号： C07K16/28 ,  A61P35/00 ,  A61K2039/507 ,  C07K16/2851 ,  C07K16/2887 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/70 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92

摘要： The invention pertains to the field of immunotherapy. The present invention provides new specific humanized anti-CLEC-1A antibodies, antigen-binding fragments thereof and mimetics thereof, in particular antibodies. The compounds of the invention are able to specifically binds to CLEC-1A receptor and antagonize the binding of CLEC-1A to its endogenous ligand(s). The use of the compounds of the invention may be useful for treating deleterious conditions.

公开(公告)号：WO2022189558A2

公开(公告)日：2022-09-15

申请号：PCT/EP2022/056162

申请日：2022-03-10

申请人： MABYLON AG ,  UNIVERSITY OF ZURICH

发明人： BIELI, Dimitri ,  WUILLEMIN, Natascha ,  PENGO, Niccolo ,  SONATI, Tiziana ,  DE ROSSI, Pierre ,  POLYMENIDOU, Magdalini ,  EMMENEGGER, Marc ,  AGUZZI, Adriano

IPC分类号： C07K16/18 ,  A61P25/00 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates to antibodies, and antigen binding fragments thereof, that specifically bind to the pathological form of TDP-43, which characterizes various TDP-43 proteinopathies. The antibodies, and antigen binding fragments thereof, decrease TDP-43 aggregation observed under pathological conditions. The invention also relates to nucleic acids that encode, and to cells that express such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies and antibody fragments in the diagnosis, treatment and prevention ofTDP-43 proteinopathies.

公开(公告)号：WO2022178216A2

公开(公告)日：2022-08-25

申请号：PCT/US2022/016926

申请日：2022-02-18

申请人： COTROPIA, Joseph ,  CHANDRA, Gaurav

发明人： COTROPIA, Joseph ,  CHANDRA, Gaurav

IPC分类号： C07K16/10 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/76

摘要： Provided are highly conserved antigens and epitopes of SARS-CoV-2 that can be used in vaccines and to produce bindings proteins (e.g., antibodies) for treating, preventing, or reducing the risks of infections caused by β-coronaviruses such as SARS-CoV-2, and as targets for detecting SARS-CoV-2 infection.

公开(公告)号：WO2022175255A2

公开(公告)日：2022-08-25

申请号：PCT/EP2022/053651

申请日：2022-02-15

申请人： JANSSEN PHARMACEUTICA NV

发明人： ATTAR, Ricardo Marcos ,  BRODEUR, Scott Ronald ,  GANESAN, Rajkumar ,  LUISTRO, Leopoldo ,  PHILIPPAR, Ulrike ,  PILLARISETTI, Kodandaram ,  JINGH, Sanjaya ,  YANG, Danlin Dan Qing

IPC分类号： A61P35/00 ,  C07K16/28 ,  C07K16/30 ,  A61K2039/505 ,  A61K2039/545 ,  C07K14/7051 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/2878 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

摘要： Provided herein are multispecific antibodies that bind to BCMA, GPRC5D and CD3 and multispecific antigen-binding fragments thereof. Also described are related polynucleotides capable of encoding the provided multispecific antibodies or multispecific antigen-binding fragments, cells expressing the provided multi specific antibodies or multispecific antigen-binding fragments, as well as associated vectors and detectably labeled multispecific antibodies or multispecific antigen-binding fragments. In addition, methods of producing and using the provided multispecific antibodies and multispecific antigen-binding fragments are described. Further provided herein are antibodies that bind to BCMA and antigen-binding fragments thereof. Also described are related polynucleotides capable of encoding the provided BCMA-specific antibodies or antigen- binding fragments, cells expressing the provided BCMA-specific antibodies or antigen- binding fragments, as well as associated vectors and detectably labeled BCMA-specific antibodies or antigen-binding fragments. In addition, methods of producing and using the provided BCMA-specific antibodies and antigen-binding fragments are described.