公开(公告)号：WO2023049781A1

公开(公告)日：2023-03-30

申请号：PCT/US2022/076830

申请日：2022-09-22

Applicant: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION

Inventor： HEWEZI, Tarek, Abdelfattah

IPC: C12N15/82 ,  C12Q1/6895

Abstract: The invention relates to genes which may be utilized to induce resistance to root-knot nematode (RKN). More specifically the present disclosure provides genes that, when inactivated, silenced, underexpressed, and/or overexpressed in a plant, particularly, a tomato plant, can confer upon the plant resistance to RKN. Methods of using these genes to obtain plants, particularly tomato plants, that are resistant to RKN are also provided.

公开(公告)号：WO2023023096A1

公开(公告)日：2023-02-23

申请号：PCT/US2022/040515

申请日：2022-08-16

Applicant: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION

Inventor： ZHANG, Feng, Yuan ,  DING, Lei ,  LI, Kui ,  XIE, Zhiqiang ,  WANG, Weitian ,  YU, Shule

IPC: C25B11/032 ,  C25B11/063 ,  C25B11/075 ,  C25B11/081 ,  C25B11/091 ,  C25B9/23 ,  H01M8/023 ,  H01M4/86 ,  H01M4/92 ,  H01M8/1004

Abstract: The presently disclosed subject matter relates to devices, systems, and methods for fabricating a solid polymer electrolyte electrode assembly are provided. One or more electrode for a solid polymer electrolyte electrode assembly includes a porous substrate configured as a liquid/gas diffusion layer and an ionomer-free catalyst coated on the substrate.

公开(公告)号：WO2022236286A1

公开(公告)日：2022-11-10

申请号：PCT/US2022/072112

申请日：2022-05-04

Applicant: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION ,  ATTRALUS, INC.

Inventor： WALL, Jonathan S. ,  FOSTER, James S. ,  PONS, Jaume

IPC: A61K38/17 ,  C07K14/47

Abstract: Provided herein are amyloid-reactive peptide-Fc fusion proteins comprising an amyloid-reactive peptide linked to a human Fc region. Also provided herein are methods of treating amyloid-based diseases and identifying amyloid deposits by administering an amyloid-reactive peptide-Fc fusion protein comprising an amyloid-reactive peptide linked to a human Fc region.

公开(公告)号：WO2022226118A1

公开(公告)日：2022-10-27

申请号：PCT/US2022/025637

申请日：2022-04-20

Applicant: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION

Inventor： BANERJEE, Souvik ,  DENG, Shanshan ,  LI, Wei ,  MAHMUD, K A Foyez ,  MILLER, Duane D. ,  WU, Zhongzhi ,  WANG, Rui ,  SEAGROVES, Tiffany ,  KRUTILINA, Raya ,  HARTMANN, Kelli ,  POCHAMPALLY, Satyanarayana

IPC: A61P35/00 ,  C07D215/20 ,  C07D215/227 ,  C07D239/24 ,  C07D239/30

Abstract: The invention encompasses novel dihydroquinoxalinone compounds with significantly improved water solubility and reduced toxicity to achieve higher therapeutic indexes and the treatment of cancer, virus infections, and inflammation using the same.

公开(公告)号：WO2021252618A1

公开(公告)日：2021-12-16

申请号：PCT/US2021/036603

申请日：2021-06-09

Applicant: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION

Inventor： DEHGHAN, Mojdeh ,  VERSLUIS, Daranee ,  ALMOAZEN, Hassan

IPC: A61K8/19 ,  A61K8/20 ,  A61K8/21 ,  A61K8/24

Abstract: An oral composition in the form of a lozenge or lollipop is provided. The composition comprises crosslinked polyvinylpyrrolidine (PVP), xylitol and Matcha green tea. A multi-layer lozenge or lollipop for neutralizing saliva and re -hardening tooth enamel is also provided. The lozenge or lollipop comprises an alkalinizing agent; a re-mineralizing agent comprising Matcha green tea; a base; a plasticizer; and a sugar alcohol, wherein the lozenge or lollipop upon oral administration raises the saliva pH from about 7 to about 10 in about 1 minute. Methods of making and treatment are also provided.

公开(公告)号：WO2021173731A1

公开(公告)日：2021-09-02

申请号：PCT/US2021/019490

申请日：2021-02-24

Applicant: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION

Inventor： NARAYANAN, Ramesh ,  PONNUSAMY, Thamarai ,  MILLER, Duane D. ,  HE, Yali ,  HWANG, Dong-Jin

IPC: A61K31/325 ,  A61K45/06 ,  C07C271/02

Abstract: This invention relates to selective androgen receptor covalent antagonists, synthetic intermediates and by-products, and related compounds, and compositions comprising the same, and uses thereof in treating androgen receptor dependent diseases and conditions such as hyperproliferations of the prostate including pre-malignancies and benign prostatic hyperplasia, prostate cancer, advanced prostate cancer, castration resistant prostate cancer, triple negative breast cancer, other cancers expressing the androgen receptor, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR.

公开(公告)号：WO2021163691A1

公开(公告)日：2021-08-19

申请号：PCT/US2021/018214

申请日：2021-02-16

Applicant: UT-BATTELLE, LLC ,  UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION

Inventor： IEVLEV, Anton V. ,  OVCHINNIKOVA, Olga S. ,  LORENZ, Matthias ,  LIU, Yongtao

IPC: G01N23/225 ,  G01N23/22 ,  G01N23/2258 ,  H01J49/14 ,  H01J49/40

Abstract: A method of performing time-of-flight secondary ion mass spectrometry on a sample includes the step of directing a beam of primary ions to the sample, and stimulating the migration of ions within the sample while the beam of primary ions is directed at the sample. The stimulation of the ions is cycled between a stimulation state and a lower stimulation state. Secondary ions emitted from the sample by the beam of primary ions are collected in a time-of-flight mass spectrometer. Time-of-flight secondary ion mass spectrometry is then performed on the secondary ions. A system for performing time-of-flight secondary ion mass spectrometry on a sample is also disclosed.

公开(公告)号：WO2021151017A1

公开(公告)日：2021-07-29

申请号：PCT/US2021/014786

申请日：2021-01-22

Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK ,  UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION ,  GEORGIA TECH RESEARCH CORPORATION

Inventor： LUBINSKY, Anthony R. ,  HOWANSKY, Adrian ,  LEONARD, Russell Lee ,  JOHNSON, Jacqueline ,  BECKERT, Meredith Brooke ,  BOND, Charles

IPC: G01T1/202 ,  C09K11/02

Abstract: Scintillating glass ceramics are disclosed. The scintillating glass ceramics may be used as an x-ray conversion layer (screen) for a flat panel imager (FPD) and as part of an imaging system. The FPD may have a single screen or a dual screen. The scintillating glass ceramics may be used for either a front screen or a back screen. The scintillating glass ceramics may be used for high energy x-ray applications including for energies of about 0.3 to about 20 MeV. A build-up layer may be attached to the scintillating glass ceramics for high energy applications. The scintillating glass ceramics may include a glass matrix hosting luminescent centers and light scattering centers. The materials used for the luminescent centers and light scattering centers may be the same or different. The scintillating glass ceramics may be coated onto a glass substrate.

公开(公告)号：WO2020243678A1

公开(公告)日：2020-12-03

申请号：PCT/US2020/035470

申请日：2020-05-30

Applicant: NORTH CAROLINA STATE UNIVERSITY ,  UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION

Inventor： YENCHO, George C. ,  OLUKOLU, Bode A.

IPC: C12Q1/6806 ,  C12Q1/6809 ,  C12Q1/683 ,  C12Q1/6855 ,  C12Q1/6869

Abstract: The present disclosure provides compositions and methods pertaining to a next-generation sequencing (NGS) library preparation protocol and method for the optimization of sequencing quality and yield. In particular, the present disclosure provides a novel sequencing platform referred to as OmeSeq, which enables high-fidelity, dosage-sensitive genotyping and strain-level metagenomic profiling of various DNA and RNA templates across animal, plant, microbial, and viral genomes.

公开(公告)号：WO2020023311A1

公开(公告)日：2020-01-30

申请号：PCT/US2019/042600

申请日：2019-07-19

Applicant: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION

Inventor： FISHER, Richard K. ,  MOUNTAIN, Deidra J.h. ,  GRANDAS, Oscar H.

IPC: A61K31/7088 ,  C07C219/06 ,  C07C229/12

Abstract: Processes for preparing neutral liposomes include adding a hydrophobic solution of liposome lipid bilayer precursors and a nucleic acid condenser to an aqueous composition of a nucleic acid condenser and a biologically active ingredient and then, isolating the liposomes. The liposomes are formed from noncationic lipids and encapsulate the biologically active ingredient as a core composition and entrap some of the biologically active ingredient on the exterior surface of the liposome. The liposomes have the nucleic acid condensers and/or cell penetrating peptides attached to the exterior surface of the lipid bilayer. One or more divalent cations are present in the solution with the liposome and remain in solution once the liposomes form.