公开(公告)号：WO2023079548A1

公开(公告)日：2023-05-11

申请号：PCT/IL2022/051157

申请日：2022-11-01

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： SCHWARTZ, Osip ,  KALI, Michael

IPC: H01J37/26 ,  H01J37/22

Abstract: A system and methods for electron beam imaging or electron beam spectroscopy. The system comprising: a transmission electron microscope (TEM) having a back focal plane; one or more laser-based devices, configured to shift a predetermined portion of an electron wave to an energy that is different from the energy originally provided by the electron source of the TEM; and an electron energy filter that is configured to accept electron waves, at the energy provided by the electron source of the TEM, and further configured to reject electron waves shifted to a different energy by the laser device.

公开(公告)号：WO2023062632A1

公开(公告)日：2023-04-20

申请号：PCT/IL2022/051082

申请日：2022-10-11

Applicant: PRILENIA NEUROTHERAPEUTICS LTD.

Inventor： HAYDEN, Michael ,  GEVA, Michal

IPC: A61K31/451 ,  A61K31/4418 ,  A61K31/4545 ,  A61P27/02 ,  A61P27/06

Abstract: This application provides a method of treating a subject afflicted with a neurodegenerative diseases comprising administering to the subject an amount of pridopidine and one of analogs 1-8 effective to treat the subject, pharmaceutical composition and uses and applications thereof.

公开(公告)号：WO2023017512A1

公开(公告)日：2023-02-16

申请号：PCT/IL2022/050864

申请日：2022-08-08

Applicant: SPLISENSE LTD.

Inventor： OREN, Yifat ,  BARCHAD-AVITZUR, Ofra ,  ELGRABLI, Renana ,  OZERI-GALAI, Efrat

IPC: C12N15/113 ,  A61K31/712 ,  A61K31/713 ,  A61P11/00 ,  A61K48/00

Abstract: The present invention provides specific synthetic oligonucleotides, as well as vectors, cells, and pharmaceutical compositions comprising the oligonucleotides, and their use in methods of treating, suppressing, or inhibiting cystic fibrosis.

公开(公告)号：WO2023278693A1

公开(公告)日：2023-01-05

申请号：PCT/US2022/035711

申请日：2022-06-30

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： MEYER, Aaron S.

IPC: A61K38/20 ,  A61K47/68 ,  A61P35/00 ,  A61P37/04 ,  A61P37/06

Abstract: The present disclosure provides a multivalent biomolecule comprising three or more covalently linked common γ-chain receptor cytokines (e.g., IL-2, IL-4, IL-7, IL-9, IL-15 or IL-21, or an immunologically active fragment thereof). In one embodiment, the common γ-chain receptor cytokines in the multivalent biomolecule are expressed as Fc fusion proteins with an IgG1 Fc. The multivalent biomolecule presented herein can be used to activate or suppress immune responses in a subject.

公开(公告)号：WO2022249178A1

公开(公告)日：2022-12-01

申请号：PCT/IL2022/050551

申请日：2022-05-25

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： NEUMANN, Ronny ,  DABBAH-AZAIZA, Dima ,  ROSENMAN, Ariel ,  TZAGUY, Avra

IPC: C25B1/00 ,  C25B1/04 ,  C25B1/55 ,  C25B9/73 ,  C07F15/02 ,  C07F15/04 ,  C07F11/00

Abstract: Provided herein a polyoxometalate compound represented by formula (I): (Q)n[XMaMbMc(La)(Lb)(Lc)W9O37] (I) or a solvate thereof; and a method of electrocatalytic reduction of carbon dioxide (CO2) using the polyoxometalate compound.

公开(公告)号：WO2022232516A1

公开(公告)日：2022-11-03

申请号：PCT/US2022/026938

申请日：2022-04-29

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： KARLIN, Justin

IPC: A61F2/14 ,  A61F2/18 ,  A61L27/36 ,  C07K14/81

Abstract: The present disclosure relates to methods for preparing ear cartilage for eyelid reconstruction, including upper eyelid reconstruction, after trauma, disease, or tumor excision. The present disclosure also relates to compositions, uses, and methods for reconstructing an eyelid. The present disclosure also relates to kits for preparing ear cartilage for eyelid reconstruction. The disclosed compositions, uses, kits, and methods may also be used for autograft, allograft, isograft, and xenograft transplantation, for stored or banked grafts, and for other therapeutic uses.

公开(公告)号：WO2022229965A1

公开(公告)日：2022-11-03

申请号：PCT/IL2022/050442

申请日：2022-04-28

Applicant: MILEUTIS LTD.

Inventor： ISCOVICH, Jose Mario ,  ISCOVICH, Javier

IPC: A61K38/07 ,  A61K38/08 ,  A61K38/17 ,  A61K31/29 ,  C07K5/10 ,  C07K14/47 ,  A61P15/14 ,  A61P31/04

Abstract: The present disclosure provides compositions and methods for modulating various mammary' disorders and conditions. The disclosure further provides a therapeutic combination of a composition of at least one casein protein or casein-derived peptide; and a teat seal composition.

公开(公告)号：WO2022107146A1

公开(公告)日：2022-05-27

申请号：PCT/IL2021/051383

申请日：2021-11-19

Applicant: PRILENIA NEUROTHERAPEUTICS LTD.

Inventor： GEVA, Michal ,  HAYDEN, Michael

IPC: A61K31/451 ,  A61K31/4418 ,  A61K31/4545 ,  A61P25/00 ,  A61P21/00

Abstract: The subject invention provides a method for treating a subject afflicted with Rett syndrome comprising administering to the subject a pharmaceutical composition comprising pridopidine or pharmaceutical acceptable salts and at least one of compounds 1-8 or pharmaceutical acceptable salt thereof disclosed herein, so as to thereby treat the subject.

公开(公告)号：WO2022085001A2

公开(公告)日：2022-04-28

申请号：PCT/IL2021/051245

申请日：2021-10-20

Applicant: RAPID DIAGNOSTIC SYSTEMS LTD

Inventor： FUERST, Oren ,  TARZAI, Ezri ,  GEVA ZATORSKY, Naama ,  KOBY, Refael Gil

IPC: B01L3/00 ,  B01L2200/0621 ,  B01L2300/047 ,  B01L2300/0832 ,  B01L2400/0478 ,  B01L3/502 ,  B01L3/50825 ,  B01L3/523 ,  B01L3/527 ,  B01L3/5635 ,  C12Q1/70

Abstract: A system for facilitating rapid diagnosis of a disease is provided. The system comprises a vial prefilled with a sample preparation reagent, a reaction chamber prefilled with an identification reagent configured to facilitate identification of an agent associated with the disease, a sample collector and a plunger. The sample collector comprises a sample-receiving member, a flow aperture, and a collector seal configured to plug the flow aperture. It is configured to be sealingly mated with the vial such that the sample receiving member is in fluid connection with the interior of the vial, and with the reaction chamber such that the flow aperture is in fluid communication with the interior of the reaction chamber. The plunger is configured to disrupt the collector seal while maintaining the seals between the sample collector and the vial and reaction chamber, thereby fluidly connecting between the interiors of the vial and reaction chamber.

公开(公告)号：WO2022059013A8

公开(公告)日：2022-03-24

申请号：PCT/IL2021/051144

申请日：2021-09-20

Applicant: BIOSIGHT LTD.

Inventor： LIDOR-HADAS, Ramy ,  SHUMILOV, Margarita ,  TESSLER, Shoshi

IPC: A61K31/7068 ,  A61K47/54 ,  A61P35/00 ,  A61P35/02

Abstract: The present invention relates to a novel crystalline polymorph of (¾)-2-amino-4-((l-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-l,2- dihydropyrimidin-4-yl)amino)-4-oxobutanoic acid (also known as BST-236, Astarabine® or aspacytarabine), processes of preparation thereof, and uses thereof for the treatment of neoplastic diseases.