公开(公告)号：WO2023023175A1

公开(公告)日：2023-02-23

申请号：PCT/US2022/040628

申请日：2022-08-17

申请人： UNITED THERAPEUTICS CORPORATION

发明人： SHELTON, Randolph Vernon Monteiro ,  SOOHOO, Jeffrey Robert ,  GREGOR, Simone Julie

IPC分类号： A01N1/02

摘要： A system (400) comprises a fluid supply (414), a pressure regulator (418), a pressure valve (420), and a vent assembly (422). The fluid supply is fluidly coupled to an outlet tube (416), which is configured to be fluidly coupled to at least a portion of an organ environment (404). The pressure regulator is configured to provide the fluid to an organ (402) in the organ environment via the outlet tube. The fluid being supplied is at a pressure range above ambient to maintain the organ in an inflated position. The pressure valve is fluidly coupled to the outlet tube and inhibits increase of the fluid pressure above a threshold. The vent assembly removes excess fluid from the organ environment and includes a vent tube disposed within the organ environment and a vent valve disposed outside of the organ environment. In another system a fluid condenser may be provided, wherein the pressure controller provides a fluid (e.g., ambient air) through a fluid valve and to the fluid condenser, which condenses the fluid (e.g., removing gases such that the supplied fluid is primarily oxygen).

公开(公告)号：WO2022236125A1

公开(公告)日：2022-11-10

申请号：PCT/US2022/028172

申请日：2022-05-06

申请人： LUNG BIOTECHNOLOGY PBC

发明人： MELICAN, Mora Carolynne ,  MURCIN, Lara ,  NSIAH, Barbara ,  LIN, Richmon ,  MORRIS, Derek ,  TRIGG, Lina ,  ALVAREZ, Luis ,  SAFAVIEH, Mohammadali ,  MODARESIFAR, Masoud ,  VYDIAM, Klayan

IPC分类号： A61L27/38 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16

摘要： The present disclosure provides reinforced hydrogel structures, methods of reinforcing hydrogel structures, and methods of treating ischemic disorders using the reinforced hydrogel structures.

公开(公告)号：WO2022132655A1

公开(公告)日：2022-06-23

申请号：PCT/US2021/063133

申请日：2021-12-13

申请人： UNITED THERAPEUTICS CORPORATION

发明人： PHARES, Kenneth Robert ,  BATRA, Hitesh ,  GUO, Liang

IPC分类号： A61K31/216 ,  A61K31/222 ,  A61K31/335 ,  A61P9/12

摘要： Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.

公开(公告)号：WO2022109316A1

公开(公告)日：2022-05-27

申请号：PCT/US2021/060165

申请日：2021-11-19

申请人： REVIVICOR, INC.

发明人： ROTHBLATT, Martine ,  AYARES, David ,  EYESTONE, Willard

IPC分类号： A01K67/027 ,  C07K14/475 ,  C07K14/65 ,  C07K14/705 ,  C07K14/74 ,  C07K14/71 ,  C12N15/85 ,  C12N15/90

摘要： The present disclosure is directed to transgenic animals (e.g., transgenic porcine animals) comprising multiple genetic modifications that advantageously render these animals suitable donors for xenotranspl anati on. The present disclosure extends to organs, organ fragments, tissues and cells derived from these animals and their therapeutic use. The present disclosure further extends to methods of making such animals. In certain embodiments, the transgenic animals (e.g., transgenic porcine animals) have reduced expression of the growth hormone receptor (GHR) gene or have impaired function of the GHR protein.

公开(公告)号：WO2022108939A1

公开(公告)日：2022-05-27

申请号：PCT/US2021/059553

申请日：2021-11-16

申请人： UNITED THERAPEUTICS CORPORATION ,  MANNKIND CORPORATION

发明人： SILVERSTEIN, Adam Marc ,  POISSON, Patrick ,  KESHAVA, Ajay ,  FREEMAN, John J., JR. ,  MILLS, James

IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K47/22 ,  A61K31/506 ,  A61P11/00

摘要： Methods of treatment of pulmonary hypertension comprising dry powder inhalation administration of imatinib, a pharmaceutically acceptable salt, or a derivative thereof, are provided. Dry powder inhalable compositions comprising imatinib, a pharmaceutically acceptable salt, or a derivative thereof, are also provided as well as methods of making the same.

公开(公告)号：WO2021113286A1

公开(公告)日：2021-06-10

申请号：PCT/US2020/062785

申请日：2020-12-02

申请人： ROSE PHARMA LLC ,  KENNY, Enda ,  WARBURG, Richard

发明人： HAWE, Andrea ,  KEILHAUER, Eva ,  POPKO, Olimpia

IPC分类号： A61K9/00 ,  A61K9/08 ,  A61K47/14 ,  A61K47/18 ,  A61K47/26 ,  A61K38/26 ,  A61P1/12 ,  A61P3/04 ,  A61P3/10

摘要： Stable liquid formulations of GLP-1 and GLP-1 analogues and method of using such formulations in the treatment of disorders or conditions are provided.

公开(公告)号：WO2020214555A1

公开(公告)日：2020-10-22

申请号：PCT/US2020/028061

申请日：2020-04-14

申请人： NORTHWESTERN UNIVERSITY

发明人： WAN, Yong ,  ZHOU, Zhuan ,  CHI, Junlong ,  SCHILTZ, Gary

IPC分类号： A61K31/506 ,  A61K45/06 ,  A61P35/00 ,  A61K31/138 ,  A61K31/337 ,  C07D403/14 ,  C07D417/14

摘要： Described herein are compounds of Formula I, or their pharmaceutically acceptable salts thereof, compositions comprising the same, and methods of using such compounds or compositions in inducing Cdc20 degradation in a cell, blocking mitotic progression, inhibiting tumor proliferation, treating cancer, and/or re-sensitizing a subject to cancer treatment with tamoxifen.

公开(公告)号：WO2023081462A1

公开(公告)日：2023-05-11

申请号：PCT/US2022/049127

申请日：2022-11-07

申请人： LUNG BIOTECHNOLOGY PBC

发明人： HURST, Greg

IPC分类号： C12M3/00 ,  C12M3/06

摘要： An apparatus can include a triply periodic minimal surface. The apparatus can include a 3D scaffold formed from the triply periodic minimal surface. The apparatus can include one or more channels formed by the 3D scaffold. A method of forming a gas exchange unit can include printing a 3D scaffold formed from a triply periodic minimal surface. The 3D scaffold can include a vascular network configured to conduct a fluid. The 3D scaffold can include one or more channels configured to hold a gas. The vascular network can be embedded inside walls of the 3D scaffold. The one or more channels can be positioned between the walls of the 3D scaffold.

公开(公告)号：WO2023028193A1

公开(公告)日：2023-03-02

申请号：PCT/US2022/041460

申请日：2022-08-25

申请人： UNITED THERAPEUTICS CORPORATION

发明人： RUSCHE, Benjamin ,  CASEY, Ashleigh ,  MICHAUX, Jennifer ,  ROUDSARI, Laila ,  DOCKHAM, Ashley R.

IPC分类号： C07K14/705 ,  C07K14/735 ,  C12N5/00 ,  C12N5/0775 ,  C12N5/071

摘要： A method is disclosed for separating cells from a lung. Mechanical pressure can be used in one stage of the process to increase the yield of separated cells, including alveolar type II cells.

公开(公告)号：WO2022236030A1

公开(公告)日：2022-11-10

申请号：PCT/US2022/028039

申请日：2022-05-06

申请人： LUNG BIOTECHNOLOGY PBC

发明人： KAUR, Aman ,  ARIAS, Isabel ,  NSIAH, Barbara ,  ALVAREZ, Luis

IPC分类号： C09D11/033 ,  B29C64/00 ,  B33Y70/00 ,  B33Y80/00 ,  C09D11/101 ,  C09D11/30

摘要： The present disclosure provides printable compositions comprising: about 1 weight percent (wt%) to about 40 wt% of one or more hydrophilic monomers; a swelling control agent selected from a hydrophobic monomer, a short chain crosslinker, or a combination thereof; about 0.01 wt% to about 2 wt% of a photo initiator; and 0 wt% to about 75 wt% of a vehicle comprising a protic solvent, by weight of the printable composition. The disclosure also includes methods of use and manufacture related to printable compositions.