公开(公告)号：WO2021221783A1

公开(公告)日：2021-11-04

申请号：PCT/US2021/020304

申请日：2021-03-01

申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY

发明人： IRVINE, Darrell, J. ,  WITTRUP, Karl, Dane ,  MEHTA, Naveen ,  MA, Leyuan ,  COSSETTE, Benjamin

IPC分类号： C07K1/04 ,  C12N15/10

摘要： The disclosure features chimeric antigen receptor (CAR) ligands, methods for making the same, and immunomodulatory compositions comprising the CAR ligands. The disclosure also features compositions and methods of using the immunomodulatory compositions, for example, to stimulate activation of CAR expressing cells.

公开(公告)号：WO2021216572A1

公开(公告)日：2021-10-28

申请号：PCT/US2021/028190

申请日：2021-04-20

申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  MILLENNIUM PHARMACEUTICALS, INC.

发明人： IRVINE, Darrell J. ,  DANE, Eric ,  OKANIWA, Masanori

IPC分类号： A61K47/54 ,  A61K47/60 ,  A61K47/69

摘要： The present disclosure provides lipid compositions comprising lipid particles (e.g., lipid nanodiscs), wherein the lipid particles (e.g., lipid nanodiscs) comprise a STING agonist amphiphile conjugate, a phospholipid and a PEG-lipid. The compositions are used in methods to induce or promote immune responses, such as immune responses useful for the treatment of cancer or infectious disease.

公开(公告)号：WO2021061648A1

公开(公告)日：2021-04-01

申请号：PCT/US2020/052005

申请日：2020-09-22

申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： IRVINE, Darrell, J. ,  DANE, Eric ,  MA, Leyuan ,  ZHANG, Angela

IPC分类号： A61K39/00 ,  A61K39/385 ,  A61P35/00 ,  C12N5/0783

摘要： Provided herein are methods and compositions for stimulating an endogenous T cell response in a subject, for example in a tumor microenvironment to enhance tumor cell lysis. In the methods and compositions of the invention, an MHC-binding antigen (e.g., MHC class I-binding peptide) is tethered to a T cell surface in inactive form, wherein upon administration and activation of the T cell the antigen is released and binds to MHC molecules on bystander cells in the subject to thereby stimulate an endogenous T cell response.

公开(公告)号：WO2020263399A1

公开(公告)日：2020-12-30

申请号：PCT/US2020/029852

申请日：2020-04-24

申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY

发明人： IRVINE, Darrell, J. ,  WITTRUP, Karl, Dane ,  MOYER, Tyson ,  AGARWAL, Yash

IPC分类号： C07K16/28 ,  C07K7/08 ,  C07K14/00 ,  A61K39/39 ,  A61K39/395 ,  A61P35/00 ,  C07K14/54 ,  C07K14/55 ,  C07K14/57

摘要： The present disclosure provides immunomodulatory fusion proteins-metal hydroxide complexes comprising an immunomodulatory domain adsorbed to a metal hydroxide via ligand exchange. The disclosure also features compositions and methods of using the same, for example, to treat cancer.

公开(公告)号：WO2020154032A1

公开(公告)日：2020-07-30

申请号：PCT/US2019/062838

申请日：2019-11-22

申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY

发明人： WANG, Chensu ,  WITTRUP, Karl, Dane ,  IRVINE, Darrell, J.

IPC分类号： A61K39/00 ,  A61K38/06 ,  A61K38/20 ,  A61K38/38 ,  A61P35/00 ,  C07K16/28 ,  C07K16/30 ,  C07K16/40

摘要： The present disclosure provides a method of treating cancer with a priming dose of combination immunotherapy comprising IL-2 (e.g., extended-PK IL-2), an immune checkpoint inhibitor, a tumor targeting antibody or integrin-binding polypeptide, and optional cancer vaccine, administered prior to maintenance doses of immune checkpoint inhibitor therapy. The methods of the disclosure can be used to treat a broad range of cancer types.

公开(公告)号：WO2020142740A1

公开(公告)日：2020-07-09

申请号：PCT/US2020/012258

申请日：2020-01-03

申请人： RESOLVE THERAPEUTICS, LLC

发明人： POSADA, James, Arthur ,  BURGE, Daniel, M.d

IPC分类号： A61K47/68

摘要： The present disclosure provides methods for treating Sjogren's disease by administering nuclease fusion proteins. The methods of the disclosure are useful to treat symptoms associated with Sjogren's disease, including fatigue.

公开(公告)号：WO2020092611A1

公开(公告)日：2020-05-07

申请号：PCT/US2019/058917

申请日：2019-10-30

申请人： CASEBIA THERAPEUTICS LIMITED LIABILITY PARTNERSHIP

发明人： COST, Gregory J. ,  UENISHI, Gene I.

IPC分类号： C12N15/90 ,  C12N5/10 ,  A01K67/027

摘要： The present application relates to compositions and methods for genome editing in cells by homology-independent mechanisms, in particular for genome editing in cells that lack the machinery necessary for repair by homology-dependent mechanisms.

公开(公告)号：WO2020033923A1

公开(公告)日：2020-02-13

申请号：PCT/US2019/046058

申请日：2019-08-09

申请人： COMPASS THERAPEUTICS LLC ,  THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY ,  MOFFITT CANCER CENTER ,  CONEJO-GARCIA, Jose, R. ,  PAYNE, Kyle, Kristopher

发明人： CONEJO-GARCIA, Jose, R. ,  PAYNE, Kyle, Kristopher ,  SCHMIDT, Michael, March ,  MCLAUGHLIN, Brooke, T. ,  BOBROWICZ, Piotr

IPC分类号： A61P35/00 ,  C07K16/28 ,  A61K39/00

摘要： The present disclosure relates to, inter alia , methods for treating, or ameliorating one or more symptoms of, cancer, with compounds (e.g., antibodies, or antigen-binding fragments thereof) that bind to CD277.

公开(公告)号：WO2019204743A1

公开(公告)日：2019-10-24

申请号：PCT/US2019/028343

申请日：2019-04-19

申请人： CHECKMATE PHARMACEUTICALS, INC.

发明人： KRIEG, Arthur, M. ,  MORRIS, Aaron, Jay

IPC分类号： C12N15/117

摘要： The present disclosure relates to, inter alia , RNA molecules (e.g., RNA hairpin agonists) that bind to and agonize RIG-I-like receptors (RLRs), and to use of the molecules in methods for treating, or ameliorating one or more symptoms of, a disorder (e.g., cancer).

公开(公告)号：WO2019200357A1

公开(公告)日：2019-10-17

申请号：PCT/US2019/027386

申请日：2019-04-12

申请人： SURFACE ONCOLOGY, INC.

发明人： PATERSON, Alison ,  PELUSO, Marisa, O. ,  LEE, Benjamin, H.

IPC分类号： G01N33/574 ,  C07K16/28 ,  C12Q1/6886

摘要： The present disclosure relates to agents that bind CD47 and comprise an Fc domain, and methods of identifying patients likely to respond to said agents. The disclosure also relates to methods for treating or ameliorating one or more symptoms of a disease, such as cancer, by administering the agent.