公开(公告)号：WO2021160700A1

公开(公告)日：2021-08-19

申请号：PCT/EP2021/053251

申请日：2021-02-10

Applicant: ADAMED PHARMA S.A.

Inventor： KIELPINSKI, Mateusz ,  RZASA, Joanna ,  KUBIAK, Bartlomiej ,  DABROWSKA, Justyna

IPC: A61K9/20

Abstract: The present invention relates to a bilayer pharmaceutical composition of ramipril and indapamide for oral administration, which can be used for treating hypertension. The pharmaceutical composition comprises: a) an immediate release layer, comprising ramipril, polyvinyl alcohol and one or more pharmaceutically acceptable excipients; and b) a sustained-release layer, comprising indapamide, a sustained-release agent being HPMC or HEC, and one or more pharmaceutically acceptable excipients.

公开(公告)号：WO2019162306A1

公开(公告)日：2019-08-29

申请号：PCT/EP2019/054171

申请日：2019-02-20

Applicant: ADAMED PHARMA S.A.

Inventor： KOLACZKOWSKI, Marcin ,  BUCKI, Adam ,  SNIECIKOWSKA, Joanna ,  MARCINKOWSKA, Monika

IPC: C07D209/10 ,  C07D235/10 ,  A61P25/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  A61K31/496

Abstract: The invention relates to new 4-(piperazin-1-yl)-2-(trifluoromethyl)-1H-indoles and 4-(piperazin-1-yl)-2-(trifluoromethyl)-1H-benzimidazolesrepresented by formula (I), wherein all symbols and variables are as defined in the description. The compounds can find use in a method of prevention and/or treatment of diseases selected from the group consistingof Alzheimer's disease, Parkinson's disease, Levy body dementia, dementia- related psychosis, schizophrenia, delusional syndromes and other psychotic conditions related and not related to taking psychoactive substances, depression, anxiety disorders of various aetiology, sleep disorders of various aetiology.

公开(公告)号：WO2019141549A9

公开(公告)日：2019-07-25

申请号：PCT/EP2019/050370

申请日：2019-01-09

Applicant: ADAMED PHARMA S.A.

Inventor： FEDER, Marcin ,  MAZUR, Maria ,  KALINOWSKA, Iwona ,  JASZCZEWSKA, Joanna ,  LEWANDOWSKI, Wojciech ,  WITKOWSKI, Jakub ,  JELEN, Sabina ,  WOS-LATOSI, Katarzyna

IPC: C07D487/10 ,  A61K31/407 ,  A61P35/00 ,  A61P37/00

Abstract: The invention relates to 1,2,3',5'- tetrahydro- 2Ή- spiropndole- 3,1 '- pyrrolo[3,4- c]pyrrole]- 2,3'- dione compounds represented by formula (I), wherein all symbols and variables are as defined in the description. The compounds can find use in a method of prevention and/or treatment of diseases selected from the group consisting of cancer, immune diseases, inflammatory conditions, allergic skin diseases associated with excessive proliferation, blinding disease and viral infections.

公开(公告)号：WO2019025512A1

公开(公告)日：2019-02-07

申请号：PCT/EP2018/070920

申请日：2018-08-01

Applicant: ADAMED PHARMA S.A.

Inventor： WOZNIAK, Lukasz

IPC: A61K9/20 ,  A61K31/00

Abstract: The invention relates to a tablet comprising 5 to 20 %wt. ezetimibe, 5 to 20 %wt. plastic excipient, 3 to 10 %wt. disintegrant, 1 to 12 %wt. starch, 0.5 to 1.5 %wt. silica, 0.5 to 2.5 %wt. stearic acid, wherein a weight ratio stearic acid to silica is 1:1 to 3:1, and wherein the tablet comprises a further diluent and binder, and optionally surfactant.

公开(公告)号：WO2023285646A1

公开(公告)日：2023-01-19

申请号：PCT/EP2022/069840

申请日：2022-07-15

Applicant: ADAMED PHARMA S.A ,  MIDAS PHARMA GMBH

Inventor： RZASA, Joanna ,  CADONAU, Stephanie

IPC: A61K9/16 ,  A61K9/48 ,  A61K31/4184 ,  A61K31/4422 ,  A61K31/549 ,  A61K47/36

Abstract: The present invention relates to fixed dose pharmaceutical compositions in the form of hard capsules comprising Amlodipine, Candesartan cilexetil and Hydrochlorothiazide for the treatment of hypertension.

公开(公告)号：WO2021162562A2

公开(公告)日：2021-08-19

申请号：PCT/PL2021/000006

申请日：2021-02-10

Applicant: ADAMED PHARMA S.A.

Inventor： RZĄSA, Joanna ,  WÓS-LATOSI, Katarzyna ,  CIEPLUCHA. Agnieszka

IPC: A61K9/20 ,  A61K9/16 ,  A61K31/00 ,  A61K45/06 ,  A61K31/403 ,  A61K31/404 ,  A61K9/1635 ,  A61K9/2027 ,  A61K9/2054

Abstract: The invention relates to a stable Ramipril granulate and a fixed dose pharmaceutical composition comprising combination of Ramipril and at least one cardiovascular active substance such as Bisoprolol fumarate, Amlodipine and/or Hydrochlorothiazide, wherein incompatibility of active substances is overcome by using a specific excipient with a dual function.

公开(公告)号：WO2020020711A3

公开(公告)日：2020-01-30

申请号：PCT/EP2019/069189

申请日：2019-07-17

Applicant: ADAMED PHARMA S.A.

Inventor： GARBERA, Kamil ,  RZASA, Joanna

IPC: A61K9/16 ,  A61K9/20 ,  A61K31/439

Abstract: The present invention relates to a solid pharmaceutical composition of cytisine for oral administration in the form of a granulate obtained by wet-granulation comprising cytisine, a binder and a porous carrier carrier free of lactose and microcrystalline cellulose, and a method for the preparation of the granulate.

公开(公告)号：WO2018188992A1

公开(公告)日：2018-10-18

申请号：PCT/EP2018/058508

申请日：2018-04-03

Applicant: ADAMED PHARMA S.A.

Inventor： BERDZIK-KALARUS, Sylwia ,  SULIKOWSKI, Daniel

IPC: A61K31/4178 ,  A61K31/4164 ,  A61K31/7048 ,  A61K45/06 ,  A61K9/00 ,  A61K9/20 ,  A61K47/06 ,  A61P31/04

Abstract: The present invention relates to furazidin for vaginal use in the treatment of a bacterial vaginal infection. Preferably, the bacterial vaginal infection is caused by Gardnerella vaginalis and/or Atopobium vaginae bacteria.

公开(公告)号：WO2021115977A1

公开(公告)日：2021-06-17

申请号：PCT/EP2020/084783

申请日：2020-12-06

Applicant: ADAMED PHARMA S.A.

Inventor： KUBIAK, Bartlomiej ,  RZASA, Joanna ,  ZARZYCKA, Mariola ,  GARBERA, Kamil

IPC: A61K9/00 ,  A61K31/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/18 ,  A61K47/26 ,  A61K47/36 ,  A61K47/38 ,  A24B15/00 ,  A61P25/00

Abstract: The present invention relates to a liquid pharmaceutical composition comprising cytisine, at least one inorganic pH-regulating agent selected from the group consisting of inorganic acids, inorganic buffers, and inorganic acid salts, and water, wherein the liquid pharmaceutical composition has a pH value between 3.0 and 7.5. The present invention furthermore relates to the liquid pharmaceutical composition for use in the treatment of tobacco smoking addiction and other forms of nicotine addiction. Additionally, the invention relates to a liquid pharmaceutical composition comprising cytisine for oral use in the treatment of tobacco smoking addiction and other forms of nicotine addiction.

公开(公告)号：WO2020020711A2

公开(公告)日：2020-01-30

申请号：PCT/EP2019/069189

申请日：2019-07-17

Applicant: ADAMED PHARMA S.A.

Inventor： GARBERA, Kamil ,  RZASA, Joanna

IPC: A61K9/16 ,  A61K9/20 ,  A61K31/439

Abstract: The present invention relates to a solid pharmaceutical composition of cytisine for oral administration in the form of a granulate obtained by wet-granulation comprising cytisine, a binder and a porous carrier carrier free of lactose and microcrystalline cellulose, and a method for the preparation of the granulate.