公开(公告)号：WO9966915A3

公开(公告)日：2000-06-15

申请号：PCT/US9913940

申请日：1999-06-22

Applicant: SOUTHERN ILLINOIS UNIVERSITY A ,  ADLER STUART R ,  DANDLIKER WALTER B

Inventor： ADLER STUART R ,  DANDLIKER WALTER B ,  MEYERS CAL Y ,  BANZ WILLIAM J ,  WINTERS TODD A ,  YUQING HOU

IPC: A61K31/19

CPC classification number: A61K31/19

Abstract: Provided are methods employing estrogenic compounds for: repressing weight gain or reducing weight in male patients; treating or preventing prostate cancer and peri- or post-menopausal symptoms; treating estrogen-responsive conditions that no longer respond to treatment with conventional steroidal estrogens; treating or preventing estrogen-responsive uterine cancer, breast cancer, and ovarian follicle atresia; inducing ovulation to increase fertility; oral contraception; treating or preventing diseases or conditions caused or prolonged by free radicals; treating or preventing cardiovascular disease, hyperlipidemia or hypercholesterolemia, and hyperglycemia; improving body fat distribution; and treating or preventing Alzheimer's disease, osteoporosis, and pattern baldness. Also provided are methods for treating or preventing prostatic diseases including benign prostate hyperplasia and other related conditions, androgen-responsive pathological conditions in males, and methods for male birth control and chemical castration, employing estrogenic carboxylic acids.

Abstract translation: 提供使用雌激素化合物的方法：抑制男性患者的体重增加或减轻体重; 治疗或预防前列腺癌和绝经后或绝经后症状; 治疗不再响应于常规甾体雌激素治疗的雌激素反应性病症; 治疗或预防雌激素反应性子宫癌，乳腺癌和卵巢卵泡闭锁; 诱导排卵增加生育能力; 口服避孕药 治疗或预防由自由基引起或延长的疾病或病症; 治疗或预防心血管疾病，高脂血症或高胆固醇血症和高血糖症; 改善身体脂肪分布; 以及治疗或预防阿尔茨海默病，骨质疏松症和模式秃发。 还提供了用于治疗或预防前列腺疾病的方法，包括良性前列腺增生和其他相关病症，男性的雄激素反应性病理状况，以及使用雌激素羧酸的男性避孕和化学阉割的方法。