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    ADIPOSE SPECIFIC PROTEIN
    1.
    发明申请
    ADIPOSE SPECIFIC PROTEIN 审中-公开
    ADIPOSE特异性蛋白质

    公开(公告)号：WO0026374A3

    公开(公告)日：2000-08-17

    申请号：PCT/EP9908351

    申请日：1999-11-02

    Applicant: SANOFI SYNTHELABO ,  FRASER ROBERT ,  ANGEL ITZCHAK ,  GUILLOT ETIENNE

    Inventor： FRASER ROBERT ,  ANGEL ITZCHAK ,  GUILLOT ETIENNE

    IPC: A61K38/00 ,  A61K39/00 ,  C07K14/575 ,  C12N15/16 ,  C12N15/17 ,  A61K38/22 ,  C07K16/26 ,  C12Q1/68

    CPC classification number: C07K14/5759 ,  A61K38/00 ,  A61K39/00

    Abstract: ASP-1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ASP-1 polypeptides and polynucleotides in the design of protocols for the treatment of obesity, cardiovascular disorders such as hypertension and arteriosclerosis, diabetes, hypo- and hyperglycemia and anorexia, among others, and diagnostic assays for such conditions.

    Abstract translation: 公开了ASP-1多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗肥胖症，心血管疾病如高血压和动脉硬化，糖尿病，低血糖和高血糖症和厌食症以及其他疾病的诊断测定方案中使用ASP-1多肽和多核苷酸的方法。

    METHOD OF TREATMENT OF DISEASE
    5.
    发明申请
    METHOD OF TREATMENT OF DISEASE 审中-公开
    治疗疾病的方法

    公开(公告)号：WO2014064697A1

    公开(公告)日：2014-05-01

    申请号：PCT/IL2013/050863

    申请日：2013-10-24

    Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. ,  GROSS, Zeev ,  HABER, Adi ,  ANGEL, Itzchak

    Inventor： GROSS, Zeev ,  HABER, Adi ,  ANGEL, Itzchak

    IPC: A61K31/409 ,  A61K31/295 ,  A61K38/41 ,  A61P3/00 ,  C07D487/22

    CPC classification number: A61K31/555 ,  A61K31/409 ,  A61K38/41 ,  C07D487/22

    Abstract: An embodiment of the invention provides a use of an effective amount of a transition metal complex of a corrole, an optically active isomer thereof, or a pharmaceutically acceptable salt thereof for treating a disease of the eye and/or the kidney in a subject suffering from diabetes. An embodiment of the invention further provides a use of a transition metal complex of a corrole, an optically active isomer thereof, or a pharmaceutically acceptable salt thereof for lowering serum glucose and serum triglyceride levels in a subject suffering from diabetes.

    Abstract translation: 本发明的一个实施方案提供了有效量的角role的过渡金属络合物，其旋光异构体或其药学上可接受的盐在治疗患有眼睛和/或肾脏的受试者的眼睛和/或肾脏疾病中的用途 糖尿病。 本发明的一个实施方案进一步提供了用于降低患有糖尿病的受试者的血清葡萄糖和血清甘油三酯水平的糠醛，其旋光异构体或其药学上可接受的盐的过渡金属络合物的用途。

    USE OF SULPHONAMIDE BENZENE DERIVATIVES TO OBTAIN A MEDICINE FOR TREATING RETROGRADE EJACULATION OR ASPERMIA
    6.
    发明申请
    USE OF SULPHONAMIDE BENZENE DERIVATIVES TO OBTAIN A MEDICINE FOR TREATING RETROGRADE EJACULATION OR ASPERMIA 审中-公开
    使用磺酰苯胺衍生物获得医药用于治疗退化或迟发性

    公开(公告)号：WO9912535A8

    公开(公告)日：1999-05-27

    申请号：PCT/FR9801927

    申请日：1998-09-10

    Applicant: SYNTHELABO ,  ANGEL ITZCHAK ,  MARTIN DENIS ,  PHILIPPO CHRISTOPHE ,  BOVY PHILIPPE ,  ARBILLA SONIA

    Inventor： ANGEL ITZCHAK ,  MARTIN DENIS ,  PHILIPPO CHRISTOPHE ,  BOVY PHILIPPE ,  ARBILLA SONIA

    IPC: A61K31/18

    CPC classification number: A61K31/18

    Abstract: The invention concerns the use of a compound of formula (I) in which: R1 represents a hydrogen or halogen atom, such a chlorine or fluorine, a linear or branched C1-C4 alkyl or C1-C4 alkoxy group; R2, R3, and R4 represent, independently of one another, a hydrogen atom, a linear or branched C1-C4 alkyl group, or a C3-C4 cycloalkyl group; and R5 represents a hydrogen atom, a C1-C2 alkyl, C1-C2 fluoroalkyl, or C1-C2 perfluoroalkyl group, for preparing a medicine useful for treating ejaculation disorders such as retrograde ejaculation or aspermia.

    Abstract translation: 本发明涉及式（I）化合物的用途，其中：R 1表示氢或卤素原子，如氯或氟，直链或支链C 1 -C 4烷基或C 1 -C 4烷氧基; R 2，R 3和R 4彼此独立地表示氢原子，直链或支链C 1 -C 4烷基或C 3 -C 4环烷基; R5代表氢原子，C1-C2烷基，C1-C2氟代烷基或C1-C2全氟烷基，用于制备可用于治疗射精病例如逆行性射精或精子症的药物。

    METHODS AND COMPOSITIONS FOR TREATING ALZHEIMER'S DISEASE
    7.
    发明申请
    METHODS AND COMPOSITIONS FOR TREATING ALZHEIMER'S DISEASE 审中-公开
    治疗阿尔茨海默病的方法和组合物

    公开(公告)号：WO2010086864A1

    公开(公告)日：2010-08-05

    申请号：PCT/IL2010/000088

    申请日：2010-02-01

    Applicant: GALMED INTERNATIONAL LTD. ,  GILAT, Tuvia ,  ANGEL, Itzchak

    Inventor： GILAT, Tuvia ,  ANGEL, Itzchak

    IPC: A61K31/575 ,  A61P25/28

    CPC classification number: A61K31/575

    Abstract: The present invention relates to methods for treatment, prevention, and inhibition of progression of Alzheimer's disease, and other brain diseases characterized by amyloid plaque deposits, comprising the administration to a subject a bile acid fatty acid conjugates or bile salt fatty acid conjugate (FABAC).

    Abstract translation: 本发明涉及用于治疗，预防和抑制阿尔茨海默病以及其他以淀粉样斑块沉积为特征的脑疾病的方法，其包括向受试者施用胆汁酸脂肪酸缀合物或胆汁盐脂肪酸缀合物（FABA​​C） 。

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