公开(公告)号：WO2009090651A3

公开(公告)日：2009-12-03

申请号：PCT/IL2009000067

申请日：2009-01-15

Applicant: TECHNION RES & DEV FOUNDATION ,  HALEVI LILACH ,  ADMON ARIE ,  BARNEA EILON ,  BEER ILAN

Inventor： HALEVI LILACH ,  ADMON ARIE ,  BARNEA EILON ,  BEER ILAN

IPC: A61K38/08 ,  A61K38/17 ,  A61P37/02 ,  C07K14/705

CPC classification number: C07K14/70539 ,  A61K38/00

Abstract: The present invention relates to multimeric HLA-B2705-peptide complexes, and their use in therapy and diagnosis of cancer and autoimmune disorders.

Abstract translation: 本发明涉及多聚体HLA-B2705-肽复合物及其在癌症和自身免疫病症的治疗和诊断中的用途。

公开(公告)号：WO2009090651A2

公开(公告)日：2009-07-23

申请号：PCT/IL2009/000067

申请日：2009-01-15

Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. ,  HALEVI, Lilach ,  ADMON, Arie ,  BARNEA, Eilon ,  BEER, Ilan

Inventor： HALEVI, Lilach ,  ADMON, Arie ,  BARNEA, Eilon ,  BEER, Ilan

CPC classification number: C07K14/70539 ,  A61K38/00 ,  Y02A50/481

Abstract: The present invention relates to multimeric HLA-B2705-peptide complexes, and their use in therapy and diagnosis of cancer and autoimmune disorders.

Abstract translation: 本发明涉及多聚HLA-B2705-肽复合物及其在治疗和诊断癌症和自身免疫疾病中的用途。

公开(公告)号：WO2002094981A3

公开(公告)日：2002-11-28

申请号：PCT/IL2002/000383

申请日：2002-05-16

Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. ,  BARNEA, Eilon ,  BEER, Ilan ,  ZIV, Tamar ,  ADMON, Arie ,  DASSAU, Lior ,  BUCHSBAUM, Samuel

Inventor： BARNEA, Eilon ,  BEER, Ilan ,  ZIV, Tamar ,  ADMON, Arie ,  DASSAU, Lior ,  BUCHSBAUM, Samuel

IPC: G01N30/00

Abstract: A method of identifying peptides originating from a particular cell type and being capable of binding to MHC molecules of a particular haplotype is disclosed. The method comprises obtaining a cell type expressing a soluble and secreted form of the MHC molecules of the particular haplotype; collecting the soluble and secreted form of the MHC molecules of the particular haplotype; and analyzing peptides bound to the soluble and secreted form of the MHC molecules of the particular haplotype, thereby identifying the peptides originating from the particular cell type and being capable of binding to MHC molecules of the particular haplotype.

公开(公告)号：WO2010125566A2

公开(公告)日：2010-11-04

申请号：PCT/IL2010000342

申请日：2010-04-27

Applicant: TECHNION RES & DEV FOUNDATION ,  ADMON ARIE ,  BARNEA EILON ,  BEER ILAN ,  ZIV TAMAR

Inventor： ADMON ARIE ,  BARNEA EILON ,  BEER ILAN ,  ZIV TAMAR

IPC: A61K38/17

CPC classification number: G01N33/57419 ,  A61K39/0011 ,  G01N2800/56

Abstract: The present invention relates to methods for detecting, prognosing and staging cancers, in particular cancers of the gastrointestinal tract. The methods of the invention comprise detecting specific protein markers in a tissue of interest, wherein the detected levels thereof may be indicative of pre-cancerous or cancerous tissue, or the stage or prognosis of a cancer. Further provided are methods of treating cancer, and cancer detection kits.

Abstract translation: 本发明涉及用于检测，预后和分期癌症，特别是胃肠道癌症的方法。 本发明的方法包括检测感兴趣的组织中的特异性蛋白质标记，其中检测的水平可以指示癌前或癌组织，或癌症的阶段或预后。 还提供了治疗癌症的方法和癌症检测试剂盒。

公开(公告)号：WO2002094981A2

公开(公告)日：2002-11-28

申请号：PCT/IL2002/000383

申请日：2002-05-16

Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. ,  BARNEA, Eilon ,  BEER, Ilan ,  ZIV, Tamar ,  ADMON, Arie ,  DASSAU, Lior ,  BUCHSBAUM, Samuel

Inventor： BARNEA, Eilon ,  BEER, Ilan ,  ZIV, Tamar ,  ADMON, Arie ,  DASSAU, Lior ,  BUCHSBAUM, Samuel

IPC: C12N

CPC classification number: G01N33/56977 ,  G01N2500/00

Abstract: A method of identifying peptides originating from a particular cell type and being capable of binding to MHC molecules of a particular haplotype is disclosed. The method comprises obtaining a cell type expressing a soluble and secreted form of the MHC molecules of the particular haplotype; collecting the soluble and secreted form of the MHC molecules of the particular haplotype; and analyzing peptides bound to the soluble and secreted form of the MHC molecules of the particular haplotype, thereby identifying the peptides originating from the particular cell type and being capable of binding to MHC molecules of the particular haplotype.

Abstract translation: 公开了鉴定源自特定细胞类型并能够结合特定单体型的MHC分子的肽的方法。 该方法包括获得表达特定单元型的MHC分子的可溶性和分泌形式的细胞类型; 收集特定单体型的MHC分子的可溶和分泌形式; 并分析与特定单元型的MHC分子的可溶性和分泌形式结合的肽，从而鉴定源自特定细胞类型并能够结合特定单倍型的MHC分子的肽。

公开(公告)号：WO2010125566A3

公开(公告)日：2010-11-04

申请号：PCT/IL2010/000342

申请日：2010-04-27

Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. ,  ADMON, Arie ,  BARNEA, Eilon ,  BEER, Ilan ,  ZIV, Tamar

Inventor： ADMON, Arie ,  BARNEA, Eilon ,  BEER, Ilan ,  ZIV, Tamar

IPC: A61K38/17 ,  C07K14/47 ,  G01N33/574

Abstract: The present invention relates to methods for detecting, prognosing and staging cancers, in particular cancers of the gastrointestinal tract. The methods of the invention comprise detecting specific protein markers in a tissue of interest, wherein the detected levels thereof may be indicative of pre-cancerous or cancerous tissue, or the stage or prognosis of a cancer. Further provided are methods of treating cancer, and cancer detection kits.