-
公开(公告)号：WO2005123759A2
公开(公告)日：2005-12-29
申请号：PCT/DK2005/000400
申请日：2005-06-17
发明人： BOCK, Eisabeth , BEREZIN, Vladimir
IPC分类号： C07K7/00
CPC分类号： C07K14/70503
摘要： The present invention relates to new peptide compounds capable of direct binding to fibroblast growth factor receptor (FGFR) and activating said receptor. The compounds of the invention comprise peptide fragments of the neural cell adhesion molecule (NCAM) derived from the fibronectin type-III module 1 (F3, 1) of NCAM. Peptide sequences of the invention are capable of stimulating learning and memory and/or neurite outgrowth and/or neural cell survival. Peptide sequences and compounds comprising thereof, according to the invention, may be beneficially used for treatment and/or prevention of different pathological conditions wherein FGFR and/or NCAM play a role in pathology and/or recovery from disease. Accordingly, pharmaceutical compositions comprising the peptide sequences and compounds of the invention are also in the scope of protection.
摘要翻译： 本发明涉及能够直接结合成纤维细胞生长因子受体（FGFR）并激活所述受体的新肽化合物。 本发明的化合物包含衍生自NCAM的纤连蛋白III型模块1（F3，1）的神经细胞粘附分子（NCAM）的肽片段。 本发明的肽序列能够刺激学习和记忆和/或神经突生长和/或神经细胞存活。 根据本发明的包含它们的肽序列及其化合物可有利地用于治疗和/或预防其中FGFR和/或NCAM在病理学和/或疾病恢复中起作用的不同病理状况。 因此，包含本发明的肽序列和化合物的药物组合物也在保护范围内。
-
公开(公告)号：WO2004056865A2
公开(公告)日：2004-07-08
申请号：PCT/DK2003/000901
申请日：2003-12-18
IPC分类号： C07K14/705
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K16/22 , G01N33/566 , G01N33/74 , G01N2333/50
摘要： The present invention relates to a method for modulating the interaction between at least two proteins, wherein at least one of the two proteins is a functional cell-surface receptor and the other protein is the receptor ligand. The invention features a binding site of said functional cell-surface receptor on the receptor ligand and discloses a series of amino acid sequences, which are part of the structure of said binding site and/or involved in the interaction between the receptor and the ligand. Moreover, the present invention features methods for molecular design and screening of a candidate compound capable of modulating the interaction between the functional cell-surface receptor and receptor ligand through the described binding site, and provides a screening assay for identification of such a compound. The invention further describes an antibody capable of binding to the above binding site and/or to an epitope comprising an amino acid sequence essential for executing the receptor ligand interaction through said binding site. The invention also concerns a variety of uses of the disclosed methods, peptide sequences and antibodies. The invention in preferred embodiments concerns the binding site of the fibroblast growth factor receptor (FGFR) on FGFR ligands, compounds capable of modulating the receptor ligand interaction through said binding site, and antibody capable of recognition of said binding site.
摘要翻译： 本发明涉及调节至少两种蛋白质之间的相互作用的方法，其中两种蛋白质中的至少一种是功能性细胞表面受体，而另一种蛋白质是受体配体。 本发明的特征在于所述功能性细胞表面受体在受体配体上的结合位点，并公开了一系列氨基酸序列，其是所述结合位点结构的一部分和/或参与受体和配体之间的相互作用。 此外，本发明的特征在于分子设计和筛选能够通过所述结合位点调节功能性细胞表面受体和受体配体之间的相互作用的候选化合物的方法，并提供了鉴定这种化合物的筛选试验。 本发明还描述了能够结合上述结合位点和/或包含通过所述结合位点执行受体配体相互作用所必需的氨基酸序列的表位的抗体。 本发明还涉及所公开的方法，肽序列和抗体的各种用途。 本发明在优选实施方案中涉及成纤维细胞生长因子受体（FGFR）对FGFR配体的结合位点，能够通过所述结合位点调节受体配体相互作用的化合物和能够识别所述结合位点的抗体。
-
3.发明申请
公开(公告)号：WO2010136031A1
公开(公告)日：2010-12-02
申请号：PCT/DK2009050119
申请日：2009-05-27
IPC分类号： C07K14/71
CPC分类号： C07K16/42 , A61K38/179 , C07K2317/70
摘要： The present invention relates to the use of peptides that are capable of binding to, and modulating the activity of NCAM. The peptides are peptide fragments of FGFRs. They are derived from two distinct binding sites for binding of the immunoglobulin-like module 2 of FGFR to NCAM F3 modules 1-2. The invention further relates to use of said peptides for the production of a medicament for the treatment of different pathological conditions, wherein NCAM and/or FGFRs play a prominent role.
摘要翻译： 本发明涉及能够结合并调节NCAM活性的肽的用途。 肽是FGFR的肽片段。 它们衍生自用于结合FGFR的免疫球蛋白样模块2与NCAM F3模块1-2的两个不同的结合位点。 本发明还涉及所述肽在生产用于治疗不同病理状况的药物中的用途，其中NCAM和/或FGFRs起着重要作用。
-
公开(公告)号：WO2008151637A2
公开(公告)日：2008-12-18
申请号：PCT/DK2008050139
申请日：2008-06-12
CPC分类号： A61K38/17
摘要： The present invention relates to peptides derived from neuroplastin which are capable of inducing neurite outgrowth by modulating intracellular calcium concentration and activity of intracellular signalling molecules such as Akt, Erk1/2 and CREB through binding and/or modulation of receptor tyrosine kinases including but not limited to Fibroblast Growth Factor receptors (FGFRs). The peptides are derived from neuroplastin or fragments thereof. The invention further relates to use of said peptides for the production of a medicament for the treatment of different pathological conditions, wherein neuroplastin and/or receptor tyrosine kinases, including but not limited to FGFRs, play a prominent role.
摘要翻译： 本发明涉及衍生自神经淀粉蛋白的肽，其能够通过结合和/或调节受体酪氨酸激酶（包括但不限于）调节细胞内钙浓度和细胞内信号分子如Akt，Erk1 / 2和CREB的活性而诱导神经突生长 成纤维细胞生长因子受体（FGFR）。 肽衍生自神经淀粉蛋白或其片段。 本发明还涉及所述肽用于生产用于治疗不同病理状况的药物的用途，其中包括但不限于FGFR的神经淀粉蛋白和/或受体酪氨酸激酶起着突出的作用。
-
公开(公告)号：WO2007093177A2
公开(公告)日：2007-08-23
申请号：PCT/DK2007/000070
申请日：2007-02-12
IPC分类号： C07K14/825 , A61K38/00
CPC分类号： C07K14/825 , A61K38/00 , C07K7/08
摘要： The present invention relates to neural cell survival, differentiation and proliferation promoting peptide fragments derived from metallothioneins (MT), pharmaceutical compositions comprising said peptide fragments and uses thereof for treatment of diseases and conditions where the effects of stimulating neural cell proliferation, differentiation and/or survival, and/or stimulating neural plasticity associated with learning and memory are beneficial for treatment.
摘要翻译： 本发明涉及来自金属硫蛋白（MT）的神经细胞存活，分化和增殖促进肽片段，包含所述肽片段的药物组合物及其用于治疗刺激神经细胞增殖，分化和/或 生存和/或刺激与学习和记忆相关的神经可塑性有益于治疗。
-
6.发明申请
公开(公告)号：WO2007071248A3
公开(公告)日：2007-06-28
申请号：PCT/DK2006/000730
申请日：2006-12-20
摘要： The present invention relates to peptide fragments derived from proteins of the S-100 family promoting neural cell survival, differentiation and proliferation. The invention further relates to pharmaceutical compositions comprising said peptide fragments and uses thereof for treatment of diseases and conditions where the effects of stimulating neural cell proliferation, differentiation and/or survival, and/or stimulating neural plasticity associated with learning and memory are beneficial for treatment.
-
公开(公告)号：WO2005123759A3
公开(公告)日：2006-05-04
申请号：PCT/DK2005000400
申请日：2005-06-17
发明人： BOCH ELISABETH , BEREZIN VLADIMIR
IPC分类号： C07K7/00 , C07K14/705 , A61K38/17 , A61P25/28 , C07K16/28
CPC分类号： C07K14/70503
摘要： The present invention relates to new peptide compounds capable of direct binding to fibroblast growth factor receptor (FGFR) and activating said receptor. The compounds of the invention comprise peptide fragments of the neural cell adhesion molecule (NCAM) derived from the fibronectin type-III module 1 (F3, 1) of NCAM. Peptide sequences of the invention are capable of stimulating learning and memory and/or neurite outgrowth and/or neural cell survival. Peptide sequences and compounds comprising thereof, according to the invention, may be beneficially used for treatment and/or prevention of different pathological conditions wherein FGFR and/or NCAM play a role in pathology and/or recovery from disease. Accordingly, pharmaceutical compositions comprising the peptide sequences and compounds of the invention are also in the scope of protection.
摘要翻译： 本发明涉及能够直接结合成纤维细胞生长因子受体（FGFR）并激活所述受体的新肽化合物。 本发明的化合物包含衍生自NCAM的纤连蛋白III型模块1（F3，1）的神经细胞粘附分子（NCAM）的肽片段。 本发明的肽序列能够刺激学习和记忆和/或神经突生长和/或神经细胞存活。 根据本发明的包含其的肽序列及其化合物可有利地用于治疗和/或预防其中FGFR和/或NCAM在病理学和/或疾病恢复中起作用的不同病理状况。 因此，包含本发明的肽序列和化合物的药物组合物也在保护范围内。
-
公开(公告)号：WO2005121168A3
公开(公告)日：2006-03-16
申请号：PCT/DK2005000382
申请日：2005-06-10
发明人： BOCK ELISABETH , BEREZIN VLADIMIR
IPC分类号： C07K14/705 , A61K38/17 , A61K39/395 , A61P25/28 , C07K7/00 , C07K16/28
CPC分类号： C07K14/70503
摘要： The invention relates to new peptide fragments capable of stimulating neurite outgrowth, stimulating of cell survival, stimulating neural plasticity associated with memory and learning, and modulating cell motility. The biological activity of the peptide fragments is associated with their capability of binding and activating a neurotrophin receptor of the Trk family. The peptide fragments of the invention comprise an amino acid motif which is essential for binding and activating a neurotrophin receptor of the Trk family. The invention also concerns pharmaceutical compositions comprising the compounds and uses thereof for prevention and/or treatment of conditions and/or diseases, wherein neurotrophing, Tkr receptors and/or NCAM play an important role, and wherein stimulating of neurite outgrowth, cell survival, neural plasticity associated with memory and learning, and/or modulating cell motility is beneficial for treatment.
摘要翻译： 本发明涉及能够刺激神经突生长，刺激细胞存活，刺激与记忆和学习相关的神经可塑性以及调节细胞运动性的新肽片段。 肽片段的生物活性与其结合并激活Trk家族的神经营养因子受体的能力相关。 本发明的肽片段包含对于结合并激活Trk家族的神经营养因子受体必需的氨基酸基序。 本发明还涉及包含该化合物的药物组合物及其用于预防和/或治疗病症和/或疾病的用途，其中神经刺激素，Tkr受体和/或NCAM起重要作用，并且其中刺激神经突生长，细胞存活，神经元 与记忆和学习相关的可塑性和/或调节细胞运动性对治疗是有益的。
-
公开(公告)号：WO2005123759A8
公开(公告)日：2006-03-09
申请号：PCT/DK2005000400
申请日：2005-06-17
发明人： BOCK ELISABETH , BEREZIN VLADIMIR
IPC分类号： C07K7/00 , C07K14/705 , A61K38/17 , A61P25/28 , C07K16/28
CPC分类号： C07K14/70503
摘要： The present invention relates to new peptide compounds capable of direct binding to fibroblast growth factor receptor (FGFR) and activating said receptor. The compounds of the invention comprise peptide fragments of the neural cell adhesion molecule (NCAM) derived from the fibronectin type-III module 1 (F3, 1) of NCAM. Peptide sequences of the invention are capable of stimulating learning and memory and/or neurite outgrowth and/or neural cell survival. Peptide sequences and compounds comprising thereof, according to the invention, may be beneficially used for treatment and/or prevention of different pathological conditions wherein FGFR and/or NCAM play a role in pathology and/or recovery from disease. Accordingly, pharmaceutical compositions comprising the peptide sequences and compounds of the invention are also in the scope of protection.
摘要翻译： 本发明涉及能够直接结合成纤维细胞生长因子受体（FGFR）并激活所述受体的新肽化合物。 本发明的化合物包含衍生自NCAM的纤连蛋白III型模块1（F3，1）的神经细胞粘附分子（NCAM）的肽片段。 本发明的肽序列能够刺激学习和记忆和/或神经突生长和/或神经细胞存活。 根据本发明的包含其的肽序列及其化合物可有利地用于治疗和/或预防其中FGFR和/或NCAM在病理学和/或疾病恢复中起作用的不同病理状况。 因此，包含本发明的肽序列和化合物的药物组合物也在保护范围内。
-
公开(公告)号：WO2005121168A2
公开(公告)日：2005-12-22
申请号：PCT/DK2005/000382
申请日：2005-06-10
发明人： BOCK, Elisabeth , BEREZIN, Vladimir
IPC分类号： C07K7/00
CPC分类号： C07K14/70503
摘要： The invention relates to new peptide fragments capable of stimulating neurite outgrowth, stimulating of cell survival, stimulating neural plasticity associated with memory and learning, and modulating cell motility. The biological activity of the peptide fragments is associated with their capability of binding and activating a neurotrophin receptor of the Trk family. The peptide fragments of the invention comprise an amino acid motif which is essential for binding and activating a neurotrophin receptor of the Trk family. The invention also concerns pharmaceutical compositions comprising the compounds and uses thereof for prevention and/or treatment of conditions and/or diseases, wherein neurotrophing, Tkr receptors and/or NCAM play an important role, and wherein stimulating of neurite outgrowth, cell survival, neural plasticity associated with memory and learning, and/or modulating cell motility is beneficial for treatment.
摘要翻译： 本发明涉及能够刺激神经突生长，刺激细胞存活，刺激与记忆和学习相关的神经可塑性以及调节细胞运动性的新肽片段。 肽片段的生物活性与其结合并激活Trk家族的神经营养因子受体的能力相关。 本发明的肽片段包含对于结合并激活Trk家族的神经营养因子受体必需的氨基酸基序。 本发明还涉及包含该化合物的药物组合物及其用于预防和/或治疗病症和/或疾病的用途，其中神经刺激素，Tkr受体和/或NCAM起重要作用，并且其中刺激神经突生长，细胞存活，神经元 与记忆和学习相关的可塑性和/或调节细胞运动性对治疗是有益的。
-
-
-
-
-
-
-
-
-
搜索结果
55 条记录 (耗时 0.021 秒)
