公开(公告)号：WO1988000476A1

公开(公告)日：1988-01-28

申请号：PCT/SE1987000319

申请日：1987-07-06

Applicant: AKTIEBOLAGET HÄSSLE ,  BERGLUND, Bengt, Göran ,  NILSON, Nils, Billy ,  NILSSON, Åke, Sigvard

Inventor： AKTIEBOLAGET HÄSSLE

IPC: A61M05/14

CPC classification number: A61M5/1409 ,  Y10T137/4891

Abstract: Device for release of a substance from a solid preparation thereof to a flowing liquid during simultaneous parenteral administration of the liquid to a patient, which device comprises a connector (1) connectable into a system for parenteral administration of the liquid, and having an inlet (6) and an outlet (12) for the liquid and means for liquid communication of said inlet and outlet with a valve device (4, 5) which comprises a mobile valve core (5) having a bypass position providing for direct liquid flow from the inlet to the outlet of the connector and a working position providing for liquid flow from the inlet (6) of the connector into a releasable container (15) for the solid preparation. The device is characterized in that the valve core (5) has an outlet means (13A) and a separate inlet means (19A) simultaneously connectable to an inlet means (14) and a separate outlet means (18) respectively on the releasable container, the releasable container further having therein means (16) for conducting the liquid from the inlet thereof to a space where it will contact the solid preparation (17), and further to the outlet of the releasable container (18), and via the valve core in a flow path to the outlet (12) of the connector.

公开(公告)号：WO1984004805A1

公开(公告)日：1984-12-06

申请号：PCT/GB1984000185

申请日：1984-05-25

Applicant: BUBB, Antony, John, Allen ,  SPIRO INVESTMENT S.A. ,  BERGLUND, Bengt

Inventor： BUBB, Antony, John, Allen ,  SPIRO INVESTMENT S.A.

IPC: F24F11/047

CPC classification number: G05D7/0106 ,  F24F11/75 ,  Y10T137/3421 ,  Y10T137/7791

Abstract: A fluid flow control valve which is responsive to the pressure drop occurring across the valve in order to maintain a substantially constant volume of fluid flow regardless of the pressures appearing at the upstream and downstream sides of the valve has a valve casing (2) with an inner face (2C) that widens outwardly from a fluid inflow end to a fluid outflow end, and a valve member (3) which is convex towards the fluid inflow end of the casing and is axially movable relatively to the casing (2) in order to vary the annular gap between the valve member (3) and the valve casing (2C). Means (25, 26) for sensing the fluid pressures at points spaced from the valve member (3) on the upstream and downstream sides thereof are coupled to a fluid pressure actuating mechanism (32, 33, 4) for acting directly upon the axially movable valve member in order to vary the axial position of the valve member (3) in accordance with the pressure drop across the valve. The valve is biased towards its open position by a biasing means (51, 52) presenting a force proportional to the closing movement of the valve member, and the shape of the inner face (2C) of the valve casing is so profiled that the coefficient of resistance presented by the valve is directly proportional to the linear closing movement of the valve member (3). This enables direct adjustment of the valve member in response to the sensed pressure drop, without the requirement for any intermediate control mechanism to compensate for the characteristics of the valve.

公开(公告)号：WO1984004798A1

公开(公告)日：1984-12-06

申请号：PCT/GB1984000186

申请日：1984-05-25

Applicant: BUBB, Antony, John, Allen ,  SPIRO INVESTMENT S.A. ,  BERGLUND, Bengt

Inventor： BUBB, Antony, John, Allen ,  SPIRO INVESTMENT S.A.

IPC: F23D11/40

CPC classification number: F23D14/62 ,  B01F5/045 ,  B01F15/0201 ,  B01F15/0293 ,  F02M69/04 ,  F23D14/60 ,  F23K5/10 ,  Y10T137/2514 ,  Y10T137/87635

Abstract: A throttled fluid mixing device comprises a valve having an axially extending valve casing (2) containing a disc-shaped valve member (3) located axially within said casing and arranged for axial movement relatively to a flared inner wall portion (2C) of said casing which is arranged to widen continuously in a direction away from its upstream end. Axial movement of the valve member (3) serves to throttle the flow of fluid through said casing, and the valve member (3) has, on its downstream side, one or more orifices (3C) from which a second fluid can be introduced into the valve casing (2) immediately on the downstream side of the valve member (3), whereby turbulent flow immediately downstream of the valve member (3) is effective to cause mixing of the two fluids. Preferably, the disc-shaped valve member has a domed or radiused frontal face, and, on its rear face, an annular recess (3A) located adjacent the rim of the disc and coupled to the orifice or orifices (3C).

公开(公告)号：WO1991006330A1

公开(公告)日：1991-05-16

申请号：PCT/SE1990000698

申请日：1990-10-26

Applicant: AKTIEBOLAGET ASTRA ,  BERGLUND, Bengt, Göran

Inventor： AKTIEBOLAGET ASTRA

IPC: A61M05/00

CPC classification number: A61M5/1409

Abstract: The invention provides a device for mixing a pharmaceutical from a solid supply into a parenterally acceptable liquid flowing through a set for parenteral administration of the liquid to a patient, said device comprising a first compartment defining a mixing space through which the liquid flows in a defined flow direction and in which the liquid mixes with the pharmaceutical in liquid solution. The device is characterized in said mixing space (15) being limited in an upper part thereof, by a generally horizontal partition (4) parallel to the flow direction in the mixing space, and a second compartment (12) extending generally vertically above said partition and being in liquid communication with the mixing space via perforations in said partition, said second compartment being closed and gas impervious in its upper end and defining a space for dissolution of the pharmaceutical in liquid penetrating through the perforations, and said second compartment further comprising a storage space where undissolved solid pharmaceutical (5) is held surrounded by entrapped gas.

Abstract translation: 本发明提供了一种用于将药物从固体供应混合到流过用于肠胃外给予患者的组的胃肠外可接受液体的装置，所述装置包括限定混合空间的第一隔室，液体通过该混合空间流动， 流动方向，其中液体与药物在液体溶液中混合。 该装置的特征在于，所述混合空间（15）在其上部通过在混合空间中平行于流动方向的大致水平的隔板（4）限制，以及第二隔室（12），其大致垂直地延伸在所述隔板 并且通过所述分隔件中的穿孔与所述混合空间液体连通，所述第二隔室在其上端是封闭的并且气体不可渗透并且限定了药物溶解在穿透穿孔的液体中的空间，并且所述第二隔室还包括 存储空间，其中未溶解的固体药物（5）被夹带的气体包围。