公开(公告)号：WO2007067617A3

公开(公告)日：2007-11-01

申请号：PCT/US2006046547

申请日：2006-12-07

Applicant: AVENTIS PHARMA INC ,  BLACK MARK ,  BOROWSKY BETH ,  ROGACKI NANCY ,  SENYAH YAW ,  STEVENS RACHEL

Inventor： BLACK MARK ,  BOROWSKY BETH ,  ROGACKI NANCY ,  SENYAH YAW ,  STEVENS RACHEL

IPC: A61K31/397 ,  A61K31/445 ,  A61K31/519 ,  A61P25/18

CPC classification number: A61K31/445 ,  A61K31/397 ,  A61K31/519

Abstract: The present invention discloses and claims a method of treating cognition deficits in a patient suffering from schizophrenia by administering to said patient a therapeutically effective amount of a CBl receptor antagonist as described herein. In another aspect, this invention also discloses and claims a combination of one or more CBl receptor antagonists and of one or more antipsychotic agents useful in the treatment of psychiatric disorders . The combination of this invention provides beneficial results in that the combination improves positive and negative symptoms of schizophrenia, while reducing weight gain and catalepsy induced by antipsychotic drugs .

Abstract translation: 本发明公开并要求通过向所述患者施用治疗有效量的本文所述的CB1受体拮抗剂来治疗患有精神分裂症患者的认知缺陷的方法。 在另一方面，本发明还公开并要求保护一种或多种CB1受体拮抗剂和一种或多种抗精神病药物用于治疗精神疾病的组合。 本发明的组合提供了有益的结果，其中组合改善精神分裂症的正和负面症状，同时降低由抗精神病药物引起的体重增加和僵住症。

公开(公告)号：WO2003105639A1

公开(公告)日：2003-12-24

申请号：PCT/AU2003/000727

申请日：2003-06-12

Applicant: RAJNAI, Marton ,  BLACK, Mark

Inventor： RAJNAI, Marton ,  BLACK, Mark

IPC: A47J27/00

CPC classification number: A47J29/00 ,  A23L5/13 ,  A47J43/20

Abstract: An apparatus (10) and method are disclosed for cooking a foodstuff whereby the foodstuff is placed in the body of the apparatus (10) which is then immersed in boiling water until the foodstuff is cooked. The apparatus (10) includes an elongated tubular body (11) having at opposite ends removable caps (12) and (13). The body (11) and caps (12) and (13) are adapted such that the cooked foodstuff adopts a shape defined by the internal surfaces of the body (11) and caps (12) and (13). An optional feature is the inclusion of a solid tube (91) which is of the same length as the body (11) and is held concentrically within the body (11) by the end caps (12) and (13). This creates a hollow core within the cooked foodstuff in which can be placed second victuals. The cross-sectional shape of the body (11) and tube (91) is determined by the required cross-sectional configuration of the cooked foodstuff and includes circular, square, rectangular, triangular, star-shaped, letters, numerals and symbols. Other optional features include fins (27) fixed to the apparatus to assist its rotation as the foodstuff is being cooked, and various means for supporting the apparatus in use dependent on whether the apparatus is used in a domestic or commercial environment.

Abstract translation: 公开了一种用于烹饪食物的设备（10）和方法，其中食物被放置在设备（10）的主体中，然后将其浸入沸水中直到食物被烹饪。 设备（10）包括细长的管状体（11），其在相对端具有可移除的盖（12）和（13）。 主体（11）和盖（12）和（13）适于使得熟食品采用由主体（11）和盖（12）和（13）的内表面限定的形状。 可选的特征是包括与主体（11）长度相同的固体管（91），并且通过端盖（12）和（13）同心地保持在主体（11）内。 这在烹饪食品中形成了一个空心的核心，可以在其中放置第二个胜利。 主体（11）和管（91）的横截面形状由烹饪食品的所需横截面构造确定，并且包括圆形，正方形，矩形，三角形，星形，字母，数字和符号。 其他可选特征包括固定到设备上的翅片（27），以便当烹饪食物时辅助其旋转，以及用于依赖于在家用或商业环境中使用该设备而使用设备的各种装置。

公开(公告)号：WO2007067617A2

公开(公告)日：2007-06-14

申请号：PCT/US2006/046547

申请日：2006-12-07

Applicant: AVENTIS PHARMACEUTICALS INC. ,  BLACK, Mark ,  BOROWSKY, Beth ,  ROGACKI, Nancy ,  SENYAH, Yaw ,  STEVENS, Rachel

Inventor： BLACK, Mark ,  BOROWSKY, Beth ,  ROGACKI, Nancy ,  SENYAH, Yaw ,  STEVENS, Rachel

CPC classification number: A61K31/445 ,  A61K31/397 ,  A61K31/519

Abstract: The present invention discloses and claims a method of treating cognition deficits in a patient suffering from schizophrenia by administering to said patient a therapeutically effective amount of a CB1 receptor antagonist as described herein. In another aspect, this invention also discloses and claims a combination of one or more CB1 receptor antagonists and of one or more antipsychotic agents useful in the treatment of psychiatric disorders. The combination of this invention provides synergistic results in that the combination improves positive and negative symptoms of schizophrenia, weight gain and catalepsy.

Abstract translation: 本发明公开并要求通过向所述患者施用治疗有效量的本文所述的CB1受体拮抗剂来治疗患有精神分裂症患者的认知缺陷的方法。 另一方面，本发明还公开并要求保护一种或多种CB1受体拮抗剂和一种或多种抗精神病药物用于治疗精神疾病的组合。 本发明的组合提供协同效果，因为该组合改善精神分裂症的积极和消极症状，体重增加和僵硬症。

公开(公告)号：WO2002064891A1

公开(公告)日：2002-08-22

申请号：PCT/GB2002/000470

申请日：2002-02-04

Applicant: SGB SERVICES LIMITED ,  BLACK, Mark, Jason

Inventor： BLACK, Mark, Jason

IPC: E01F8/00

CPC classification number: F16B2/185 ,  E01F8/0023 ,  E04B2/7438 ,  F16B21/09 ,  F16B21/10

Abstract: A form of connection between a post and a panel is disclosed. The connection is particularly suitable for use in noise-absorbing barriers which are sometimes mounted in position, adjacent a road or a railway, the panels of which are supported on a plurality of spaced-apart posts. The post carries a formation comprising a vertical arcuate wall and a vertical element spaced therefrom presenting a generally cylindrical exterior wall. The centre of the vertical element is substantially coincident with the centre of curvature of the arcuate wall and there is provided an arcuate channel of substantially uniform width between the vertical element and the arcuate wall. A connecting element carries a substantially semi-circular wall which is dimensioned to be received within the channel. Clamping means are mounted on the post and are adapted to engage the semi-circular wall to clamp the panel in position. The clamping means comprises a wedge arrangement.

Abstract translation: 公开了一种柱和板之间的连接形式。 该连接特别适用于有时安装在位于邻近道路或铁路的位置的噪声吸收障碍物中，其屏障被支撑在多个间隔开的柱上。 该柱承载包括垂直弓形壁和与其间隔开的垂直元件的结构，其具有大致圆柱形的外壁。 垂直元件的中心基本上与弓形壁的曲率中心一致，并且在垂直元件和弧形壁之间设置有基本均匀宽度的弓形通道。 连接元件承载基本上半圆形的壁，其尺寸被设计成容纳在通道内。 夹紧装置安装在柱上并且适于接合半圆形壁以将面板夹紧就位。 夹紧装置包括楔形装置。