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公开(公告)号：WO1994025045A1
公开(公告)日：1994-11-10
申请号：PCT/US1994004736
申请日：1994-04-29
Applicant: MERCK & CO., INC. , BALKOVEC, James, M. , BOUFFARD, Frances, Aileen , DROPINSKI, James, F.
Inventor： MERCK & CO., INC.
IPC: A61K37/00
Abstract: A compound having formula (I) in which R1 is an aminoalkyl group and (a) is an acyl group, and salts thereof. The compounds have antibiotic activity.
Abstract translation: R1为氨基烷基，（a）为酰基的式（I）化合物及其盐。 这些化合物具有抗生素活性。
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公开(公告)号：WO1994009033A1
公开(公告)日：1994-04-28
申请号：PCT/US1993009606
申请日：1993-10-07
Applicant: MERCK & CO., INC. , BOUFFARD, Frances, Aileen , DROPINSKI, James, F.
Inventor： MERCK & CO., INC.
IPC: C07K07/64
CPC classification number: C07K7/56
Abstract: An improved process for the preparation of cyclohexapeptidyl bisamine compounds represented by formula (I) and which are potent fungicidal and parasiticidal agents is described.
Abstract translation: 描述了制备由式（I）表示的并且是有效的杀真菌剂和杀寄生剂的环己基肽基双胺化合物的改进方法。
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Patent Agency Ranking
公开(公告)号：WO2009045311A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/011100
申请日：2008-09-25
Applicant: MERCK & CO., INC. , SCYNEXIS, INC. , BALKOVEC, James, M. , SILIPHAIVANH, Phieng , BOUFFARD, Frances, Aileen , PEEL, Michael, R. , FAN, Weiming , MAMAI, Ahmed , DIMICK GRAY, Sarah, M.
Inventor： BALKOVEC, James, M. , SILIPHAIVANH, Phieng , BOUFFARD, Frances, Aileen , PEEL, Michael, R. , FAN, Weiming , MAMAI, Ahmed , DIMICK GRAY, Sarah, M.
IPC: A61K31/497
CPC classification number: C07J71/0005
Abstract: Novel derivatives of enfumafungin are disclosed herein, along with their, pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antifungal agents and/or inhibitors of (l,3)-β-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.
Abstract translation: 本文公开了enfumafungin的新型衍生物及其药学上可接受的盐，水合物和前药。 还公开了包含这种化合物的组合物，制备这些化合物的方法和使用这种化合物作为抗真菌剂和/或（1,3）-β-D-葡聚糖合酶抑制剂的方法。 所公开的化合物，其药学上可接受的盐，水合物和前药，以及包含这些化合物，盐，水合物和前药的组合物可用于治疗和/或预防真菌感染和相关疾病和病症。
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公开(公告)号：WO1994021677A1
公开(公告)日：1994-09-29
申请号：PCT/US1994002580
申请日：1994-03-10
Applicant: MERCK & CO. INC. , BALKOVEC, James, M. , BOUFFARD, Frances, Aileen , BLACK, Regina, M.
Inventor： MERCK & CO. INC.
IPC: C07K07/56
CPC classification number: C07K7/56 , A61K38/00 , Y10S930/27
Abstract: Certain aza cyclohexapeptide compounds have been found to have superior antibiotic properties. Novel processes for their preparation are also described.
Abstract translation: 已经发现某些氮杂环己肽具有优异的抗生素特性。 还描述了其新型制备方法。
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公开(公告)号：WO1994025048A1
公开(公告)日：1994-11-10
申请号：PCT/US1994004042
申请日：1994-04-13
Applicant: MERCK & CO., INC. , BALKOVEC, James, M. , BOUFFARD, Frances, Aileen , DROPINSKI, James, F. , ZAMBIAS, Robert, A.
Inventor： MERCK & CO., INC.
IPC: A61K37/02
Abstract: Certain amine compounds which have a cyclohexapeptidyl nucleus and which are found to have antibiotic activity with physical properties suitable for direct use in therapeutic compositions are described. A novel process for their preparation is also described.
Abstract translation: 描述了具有环己肽基核并且被发现具有适于直接用于治疗组合物的物理性质的抗生素活性的某些胺化合物。 还描述了其制备的新方法。
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公开(公告)号：WO2007127012B1
公开(公告)日：2008-02-21
申请号：PCT/US2007007856
申请日：2007-03-29
Applicant: MERCK & CO INC , SCYNEXIS INC , BALKOVEC JAMES M , BOUFFARD FRANCES AILEEN , TSE BRUNO , DROPINSKI JAMES , MENG DONGFANG , GREENLEE MARK L , PEEL MICHAEL , FAN WEIMING , MAMAI AHMED , LIU HAO , LI KEQAING
Inventor： BALKOVEC JAMES M , BOUFFARD FRANCES AILEEN , TSE BRUNO , DROPINSKI JAMES , MENG DONGFANG , GREENLEE MARK L , PEEL MICHAEL , FAN WEIMING , MAMAI AHMED , LIU HAO , LI KEQAING
CPC classification number: C07J71/0005
Abstract: The present invention relates to novel enfumafungin derivatives of formula I and pharmaceutically acceptable salts thereof, their synthesis, and their use as inhibitors of (l,3)-ß-D-glucan synthase. The present compounds and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the present compounds and pharmaceutically acceptable salts thereof, are useful for treating or preventing antifungal infections and associated diseases and conditions.
Abstract translation: 本发明涉及式I的新型烯虫腈衍生物及其药学上可接受的盐，其合成及其作为（1,3）-β-D-葡聚糖合酶抑制剂的用途。 本发明化合物及其药学上可接受的盐，以及包含本发明化合物及其药学上可接受的盐的药物组合物可用于治疗或预防抗真菌感染和相关疾病和病症。
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公开(公告)号：WO2007127012A1
公开(公告)日：2007-11-08
申请号：PCT/US2007/007856
申请日：2007-03-29
Applicant: MERCK & CO., INC. , SCYNEXIS, INC. , BALKOVEC, James, M. , BOUFFARD, Frances, Aileen , TSE, Bruno , DROPINSKI, James , MENG, Dongfang , GREENLEE, Mark, L. , PEEL, Michael , FAN, Weiming , MAMAI, Ahmed , LIU, Hao , LI, Keqaing
Inventor： BALKOVEC, James, M. , BOUFFARD, Frances, Aileen , TSE, Bruno , DROPINSKI, James , MENG, Dongfang , GREENLEE, Mark, L. , PEEL, Michael , FAN, Weiming , MAMAI, Ahmed , LIU, Hao , LI, Keqaing
CPC classification number: C07J71/0005
Abstract: The present invention relates to novel enfumafungin derivatives of formula I and pharmaceutically acceptable salts thereof, their synthesis, and their use as inhibitors of (l,3)-β-D-glucan synthase. The present compounds and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the present compounds and pharmaceutically acceptable salts thereof, are useful for treating or preventing antifungal infections and associated diseases and conditions.
Abstract translation: 本发明涉及式I的新型烯虫腈衍生物及其药学上可接受的盐，其合成及其作为（1,3）-β-D-葡聚糖合酶抑制剂的用途。 本发明化合物及其药学上可接受的盐以及包含本发明化合物及其药学上可接受的盐的药物组合物可用于治疗或预防抗真菌感染和相关疾病和病症。
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