公开(公告)号：WO2023065014A1

公开(公告)日：2023-04-27

申请号：PCT/CA2022/051504

申请日：2022-10-13

Applicant: BRIGHT ANGEL THERAPEUTICS INC.

Inventor： JAIKARAN, Dominic ,  SLASSI, Abdelmalik ,  SHELLEY, Mee ,  PLACZEK, Andrew ,  DING, Kejia ,  GE, Jinzhu

IPC: C07D495/04 ,  A01N43/84 ,  A01N43/90 ,  A01N43/653 ,  A01N47/16 ,  A01N47/18 ,  A01N47/38 ,  A01N47/44 ,  A01N57/34 ,  A01N61/00 ,  A01P3/00 ,  A61K31/55 ,  A61K31/538 ,  A61K31/4196 ,  A61K31/4985 ,  A61K47/54 ,  A61P31/10 ,  C07D403/12

Abstract: The present application relates conjugate compounds of Formula (I); wherein: A is a moiety that increases fungal cell uptake and/or fungal cell permeability; B is a HSP90 inhibiting moiety; and L1 is a linker; or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment or prevention of fungal-related diseases, disorders or conditions.

公开(公告)号：WO2023077216A1

公开(公告)日：2023-05-11

申请号：PCT/CA2022/051607

申请日：2022-10-31

Applicant: BRIGHT ANGEL THERAPEUTICS INC.

Inventor： JAIKARAN, Dominic ,  SLASSI, Abdelmalik ,  SHELLEY, Mee ,  PLACZEK, Andrew ,  DING, Kejia ,  GE, Jinzhu ,  ARNS, Stephen ,  JAQUITH, James ,  CRAWFORD, Jason ,  HELLER, Markus ,  HSIEH, Tom ,  TAN, Jason ,  SHIDMOOSSAVEE, Fahimeh

IPC: C07D495/04 ,  A01N43/90 ,  A01N47/44 ,  A01P3/00 ,  A61K31/517 ,  A61K31/538 ,  A61K31/4985 ,  A61K31/5386 ,  A61P31/10 ,  C07D487/04 ,  C07D495/14 ,  C07D519/00

Abstract: The present application relates compounds of Formula (I): or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment or prevention of fungal-related diseases, disorders or conditions.