公开(公告)号：WO2011048110A1

公开(公告)日：2011-04-28

申请号：PCT/EP2010/065742

申请日：2010-10-19

Applicant: UNIVERSITÉ PARIS DIDEROT - PARIS 7 ,  ASNACIOS, Atef ,  MITROSSILIS, Démosthène ,  BROWAEYS, Julien

Inventor： ASNACIOS, Atef ,  MITROSSILIS, Démosthène ,  BROWAEYS, Julien

IPC: G01N3/24

CPC classification number: G01N3/24 ,  G01N2203/0089 ,  G01N2203/0091 ,  G01N2203/0236

Abstract: A method for determining the response of a contractile or expansible biological material to a variation of the rigidity of its environment comprising the steps of: a) placing a sample (100) of the biological material between a force measurement device (200, 500) and a rigid support (300, 600); b) choosing an effective rigidity value, k eff , of the environment of the sample (100); c) maintaining the contacting area in a constant position by applying a force, F(t), where F(t) = k o .δ(t) and where δ(t) is the stretching of the elastic probe; - simultaneously translating the rigid support of a distance D(t), where D(t) = δ(t).(k o /k eff ); - determining the response of the biological material sample (100); d) repeating steps b) and c) when choosing an effective rigidity value different from former effective rigidity value when the sample (100) remains in situ.

Abstract translation: 一种用于确定收缩或可膨胀生物材料对其环境刚度变化的响应的方法，包括以下步骤：a）将生物材料的样品（100）放置在力测量装置（200,500）和 刚性支撑（300,600）; b）选择样品（100）的环境的有效刚度值keff; c）通过施加力F（t）将接触面积保持在恒定位置，其中F（t）= ko.d（t），其中d（t）是弹性探针的拉伸; - 同时平移距离D（t）的刚性支撑，其中D（t）= d（t）。（ko / keff）; - 确定生物材料样品的响应（100）; d）当样品（100）保持原位时，选择与先前有效刚度值不同的有效刚度值时，重复步骤b）和c）。