公开(公告)号：WO2023034056A1

公开(公告)日：2023-03-09

申请号：PCT/US2022/041038

申请日：2022-08-22

申请人： BIONAUT LABS LTD. ,  BROWN, Tobin ,  CHO, Suehyun ,  STANTON, Marty ,  KISELYOV, Alex

发明人： BROWN, Tobin ,  CHO, Suehyun ,  STANTON, Marty ,  KISELYOV, Alex

IPC分类号： A61K31/713 ,  A61K31/7088 ,  A61K47/10 ,  C12N15/11

摘要： The present invention relates to compositions of a dried rapid-release high concentration oligonucleotide-loaded PEG hydrogel-based matrix, methods for formulating hydrogel matrix-encapsulated oligonucleotides in an amount that exceeds the oligonucleotides intrinsic solubility in water or aqueous media, the hydrogel matrix-encapsulated oligonucleotides produced by the described methods, and therapeutic methods for using the dried rapid-release high concentration hydrogel matrix-encapsulated oligonucleotides for systemic and local micro-delivery.