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公开(公告)号：WO2023084235A1
公开(公告)日：2023-05-19
申请号：PCT/GB2022/052866
申请日：2022-11-11
发明人： LEHNER, Paul J. , BLOOR, Stuart , SECZYNSKA, Marta
IPC分类号： A61K48/00
摘要： The invention provides methods for reducing HUSH-mediated repression of transgene expression and to vectors and inhibitors for use in said methods. The present invention is particularly suitable for use in in vitro expression and for use in in vivo therapy, such as gene therapy.
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公开(公告)号：WO2023073384A1
公开(公告)日：2023-05-04
申请号：PCT/GB2022/052752
申请日：2022-11-01
发明人： LEVIN, Aviad , KNOWLES, Tuomas
IPC分类号： G01N33/68
摘要： The disclosure relates to methods of investigating protein aggregation reactions, in particular methods for detecting aggregates of a protein that are capable of seeding further protein aggregation. The methods allow not only understanding of aggregation reactions, but also provide means for detecting whether a sample from an individual comprises aggregate seeds.
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公开(公告)号：WO2023041799A1
公开(公告)日：2023-03-23
申请号：PCT/EP2022/076077
申请日：2022-09-20
发明人： CHHOWALLA, Manish , LI, Zhuangnan
IPC分类号： H01M4/136 , H01M4/1397 , H01M4/36 , H01M4/38 , H01M10/052 , H01M4/62 , H01M4/02
摘要： The invention relates to a lithium sulfur cell, a method of preparing a lithium sulfur cell, and a battery comprising the lithium sulfur cell. The lithium sulfur cell comprises a working electrode comprising a film comprising stacked layers of a metallic phase transition metal dichalcogenide of formula (I): LiaMX2 where a is from 0.0 to 2.0, X is selected from S, Se and Te, and M is a transition metal, such as Ti, Hf, V, Nb, Ta, Mo, W, Tc, Re, Pd or Pt. The method of preparing a lithium sulfur cell comprises: exfoliating a transition metal dichalcogenide to provide a metallic phase, transition metal dichalcogenide of formula (I); assembling a working electrode comprising a film comprising stacked layers of the metallic phase transition metal dichalcogenide and sulfur or a lithium (poly)sulfide; and assembling a lithium sulfur cell comprising the working electrode, a counter electrode, and an electrolyte.
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公开(公告)号：WO2023025941A1
公开(公告)日：2023-03-02
申请号：PCT/EP2022/073790
申请日：2022-08-26
摘要： The invention relates to a method for coating an electrode active material with a metal oxide, a method for doping an electrode active material, and coated and doped electrode active materials produced by the methods. The coated and doped electrode active materials can be used in electrochemical cells. The method for coating an electrode active material comprises providing a coating composition comprising an organic solvent and a bimetallic alkoxide, depositing the coating composition to the surface of the electrode active material, and calcining the electrode active material to provide a coating of bimetallic oxide on the surface of the electrode active material. Compared to using two separate metal coating precursors, the bimetallic alkoxide acts as a single-source coating precursor, which provides a highly-uniform coating, accurate control of coating thickness and metal stoichiometry.
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公开(公告)号：WO2023017262A1
公开(公告)日：2023-02-16
申请号：PCT/GB2022/052082
申请日：2022-08-10
IPC分类号： A61K31/722 , A61K31/785 , A61P35/00 , A61K31/132
摘要： The present invention relates to the field of brain tumour treatment. The invention provides methods of killing brain tumour cells in these tissues using high concentrations of cytotoxic agents which are capable of binding strongly to normal brain extracellular matrix (ECM), but less strongly to extracellular matrix components in the tumour environment. The cytotoxic agent is a polyamine, e.g. spermidine or putrescine.
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公开(公告)号：WO2022248714A1
公开(公告)日：2022-12-01
申请号：PCT/EP2022/064486
申请日：2022-05-27
IPC分类号： G06F7/544 , G06F16/2458 , G06F16/2462 , G06F17/18 , G06F9/30014 , G06F9/30101
摘要： A computer-implemented method for the encoding of, and computation on, distributions of data, the method comprising: obtaining a first set of data items; obtaining a second set of data items; generating a first tuple containing parameters encoding a probability distribution characterising the distribution of the data items of the first set; generating a second tuple containing parameters encoding a probability distribution characterising the distribution of the data items of the second set in which the parameters used to encode the distribution of the data items of the second set are the same as the parameters used to encode the distribution of the data items of the first set; generating a third tuple using parameters contained within the first tuple and using parameters contained within the second tuple, the third tuple containing parameters encoding a probability distribution representing the result of applying an arithmetic operation on the first probability distribution and the second probability distribution; outputting the third tuple.
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公开(公告)号：WO2022172023A1
公开(公告)日：2022-08-18
申请号：PCT/GB2022/050375
申请日：2022-02-11
发明人： KNOWLES, Tuomas Pertti Jonathan , JACQUAT, Raphael Philippe Bernard , MUELLER, Thomas , PETER, Quentin
摘要： A method of determining diffusion coefficient of one or more components in a polydisperse sample is provided. The method comprising the steps of: introducing an auxiliary fluid flow into a fractionation channel; introducing the polydisperse sample comprising one or more components into the fractionation channel; allowing the sample and the auxiliary fluid to create a combined flow; fractionating the combined flow into two or more fractions by diffusive sizing; subsequently separating two or more components from each fraction by creating a distribution of the components within a separation channel; detecting a characteristic of each the two or more components in each fraction; and comparing the characteristic of each component in each fraction in order to determine the diffusion coefficient of each of the one or more components in the polydisperse sample.
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公开(公告)号：WO2022161952A1
公开(公告)日：2022-08-04
申请号：PCT/EP2022/051642
申请日：2022-01-25
摘要： Techniques for driving a directly modulated laser whilst correcting non-linearities an optical output waveform, based on generating a modulating current waveform that approximates an ideal modulating current that produces a linear optical output waveform. The techniques enable useful, practical approximations to the ideal modulating current to be determined.
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公开(公告)号：WO2022043709A1
公开(公告)日：2022-03-03
申请号：PCT/GB2021/052238
申请日：2021-08-27
摘要： A microfluidic sensor comprising: a first substrate; a second substrate; a cavity formed between the first substrate and the second substrate, the cavity comprising a reservoir portion and a channel portion extending from the reservoir portion; a capacitive element disposed between the first substrate and the second substrate, the capacitive element being at least partially disposed in the channel portion of the cavity; and a dielectric sensing liquid provided in the reservoir portion. Upon application of a force to the first substrate adjacent the reservoir portion, the reservoir portion is configured to deform and displace the sensing liquid along the channel portion, so as to change the capacitance of the capacitive element within the channel portion.
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公开(公告)号：WO2022034177A1
公开(公告)日：2022-02-17
申请号：PCT/EP2021/072517
申请日：2021-08-12
IPC分类号： C12Q1/6876
摘要： The present invention provides methods for the non-enzymatic cleavage of target nucleic acids, for example for use in epigenomic and epitranscriptomic mapping and therapy. The method comprises contacting a target nucleic acid molecule with a bifunctional probe comprising a cleavage group and a covalent binding group such that the bifunctional probe covalently binds to the target nucleic acid molecule and cleaves the 5 target nucleic acid molecule bound thereto. Also provided is a method of selectively cleaving a target nucleic acid in a cell, a method for determining the modification of nucleic acid molecules by a nucleic acid modification enzyme in a cell, and a bifunctional probe for use in the methods.
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